A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum (original) (raw)
References
von Heijne, G. Signal sequences. The limits of variation. J. Mol. Biol.184, 99–105 (1985) ArticleCAS Google Scholar
Randall, L. L. & Hardy, S. J. Unity in function in the absence of consensus in sequence: role of leader peptides in export. Science243, 1156–1159 (1989) ArticleADSCAS Google Scholar
Rapoport, T. A., Jungnickel, B. & Kutay, U. Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes. Annu. Rev. Biochem.65, 271–303 (1996) ArticleCAS Google Scholar
Johnson, A. E. & van Waes, M. A. The translocon: a dynamic gateway at the ER membrane. Annu. Rev. Cell Dev. Biol.15, 799–842 (1999) Article Google Scholar
Jungnickel, B. & Rapoport, T. A. A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane. Cell82, 261–270 (1995) ArticleCAS Google Scholar
Crowley, K. S., Liao, S., Worrell, V. E., Reinhart, G. D. & Johnson, A. E. Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore. Cell78, 461–471 (1994) ArticleCAS Google Scholar
Rutkowski, D. T., Lingappa, V. R. & Hegde, R. S. Substrate-specific regulation of the ribosome–translocon junction by N-terminal signal sequences. Proc. Natl Acad. Sci. USA98, 7823–7828 (2001) ArticleADSCAS Google Scholar
Kim, S. J., Mitra, D., Salerno, J. R. & Hegde, R. S. Signal sequences control gating of the protein translocation channel in a substrate-specific manner. Dev. Cell2, 207–217 (2002) ArticleCAS Google Scholar
Foster, C. A. et al. Pharmacological modulation of endothelial cell-associated adhesion molecule expression: implications for future treatment of dermatological diseases. J. Dermatol.21, 847–854 (1994) ArticleCAS Google Scholar
Chen, Y., Bilban, M., Foster, C. A. & Boger, D. L. Solution-phase parallel synthesis of a pharmacophore library of HUN-7293 analogues: a general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides. J. Am. Chem. Soc.124, 5431–5440 (2002) ArticleCAS Google Scholar
Kunkel, E. J. et al. Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. Assay Drug Dev. Technol.2, 431–441 (2004) ArticleCAS Google Scholar
Lindley, I. J. D., Marquardt-Gehrke, K. F. & Dascher-Nadel, C. Screening assay for cotranslational translocation interfering compounds. US Patent Application No. 20040086904 (2004)
Kurzchalia, T. V. et al. The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle. Nature320, 634–636 (1986) ArticleADSCAS Google Scholar
Krieg, U. C., Walter, P. & Johnson, A. E. Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle. Proc. Natl Acad. Sci. USA83, 8604–8608 (1986) ArticleADSCAS Google Scholar
Voigt, S., Jungnickel, B., Hartmann, E. & Rapoport, T. A. Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane. J. Cell Biol.134, 25–35 (1996) ArticleCAS Google Scholar
Wolin, S. L. & Walter, P. Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes. J. Cell Biol.121, 1211–1219 (1993) ArticleCAS Google Scholar
Gorlich, D., Hartmann, E., Prehn, S. & Rapoport, T. A. A protein of the endoplasmic reticulum involved early in polypeptide translocation. Nature357, 47–52 (1992) ArticleADSCAS Google Scholar
Fons, R. D., Bogert, B. A. & Hegde, R. S. Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane. J. Cell Biol.160, 529–539 (2003) ArticleCAS Google Scholar
Deshaies, R. J., Sanders, S. L., Feldheim, D. A. & Schekman, R. Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex. Nature349, 806–808 (1991) ArticleADSCAS Google Scholar
Panzner, S., Dreier, L., Hartmann, E., Kostka, S. & Rapoport, T. A. Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p. Cell81, 561–570 (1995) ArticleCAS Google Scholar
Hamman, B. D., Hendershot, L. M. & Johnson, A. E. BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation. Cell92, 747–758 (1998) ArticleCAS Google Scholar
Lyman, S. K. & Schekman, R. Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP. Cell88, 85–96 (1997) ArticleCAS Google Scholar
Tyedmers, J., Lerner, M., Wiedmann, M., Volkmer, J. & Zimmermann, R. Polypeptide-binding proteins mediate completion of co-translational protein translocation into the mammalian endoplasmic reticulum. EMBO Rep.4, 505–510 (2003) ArticleCAS Google Scholar
Gorlich, D. & Rapoport, T. A. Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane. Cell75, 615–630 (1993) ArticleCAS Google Scholar
Mothes, W., Jungnickel, B., Brunner, J. & Rapoport, T. A. Signal sequence recognition in cotranslational translocation by protein components of the endoplasmic reticulum membrane. J. Cell Biol.142, 355–364 (1998) ArticleCAS Google Scholar
Plath, K., Mothes, W., Wilkinson, B. M., Stirling, C. J. & Rapoport, T. A. Signal sequence recognition in posttranslational protein transport across the yeast ER membrane. Cell94, 795–807 (1998) ArticleCAS Google Scholar
Van den Berg, B. et al. X-ray structure of a protein-conducting channel. Nature427, 36–44 (2004) ArticleCAS Google Scholar
Boger, D. L., Keim, H., Oberhauser, B., Schreiner, E. P. & Foster, C. A. Total synthesis of HUN-7293. J. Am. Chem. Soc.121, 6197–6205 (1999) ArticleCAS Google Scholar