Vertebrate Smoothened functions at the primary cilium (original) (raw)
Huangfu, D. et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature426, 83–87 (2003) ArticleCASADS Google Scholar
Liu, A., Wang, B. & Niswander, L. A. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development132, 3103–3111 (2005) ArticleCAS Google Scholar
Hooper, J. E. & Scott, M. P. Communicating with Hedgehogs. Nature Rev. Mol. Cell Biol.6, 306–317 (2005) ArticleCAS Google Scholar
Dwyer, N. D., Troemel, E. R., Sengupta, P. & Bargmann, C. I. Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Cell93, 455–466 (1998) ArticleCAS Google Scholar
Wheatley, D. N. Primary cilia in normal and pathological tissues. Pathobiology63, 222–238 (1995) ArticleCAS Google Scholar
Salisbury, J. L. Primary cilia: putting sensors together. Curr. Biol.14, R765–R767 (2004) ArticleCAS Google Scholar
Takemoto, D. J. & Cunnick, J. M. Visual transduction in rod outer segments. Cell. Signal.2, 99–104 (1990) ArticleCAS Google Scholar
Sulik, K. et al. Morphogenesis of the murine node and notochordal plate. Dev. Dyn.201, 260–278 (1994) ArticleCAS Google Scholar
Zhang, X. M., Ramalho-Santos, M. & McMahon, A. P. Smoothened mutants reveal redundant roles for Shh and Ihh signalling including regulation of L/R symmetry by the mouse node. Cell106, 781–792 (2001) ArticleCAS Google Scholar
Roelink, H. et al. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell76, 761–775 (1994) ArticleCAS Google Scholar
Zhu, A. J., Zheng, L., Suyama, K. & Scott, M. P. Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev.17, 1240–1252 (2003) ArticleCAS Google Scholar
Denef, N., Neubuser, D., Perez, L. & Cohen, S. M. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell102, 521–531 (2000) ArticleCAS Google Scholar
Nakano, Y. et al. Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.. Mech. Dev.121, 507–518 (2004) ArticleCAS Google Scholar
Incardona, J. P., Gruenberg, J. & Roelink, H. Sonic hedgehog induces the segregation of patched and smoothened in endosomes. Curr. Biol.12, 983–995 (2002) ArticleCAS Google Scholar
Chen, J. K., Taipale, J., Cooper, M. K. & Beachy, P. A. Inhibition of Hedgehog signalling by direct binding of cyclopamine to Smoothened. Genes Dev.16, 2743–2748 (2002) ArticleCAS Google Scholar
Dwyer, N. D., Adler, C. E., Crump, J. G., L'Etoile, N. D. & Bargmann, C. I. Polarized dendritic transport and the AP-1 mu1 clathrin adaptor UNC-101 localize odorant receptors to olfactory cilia. Neuron31, 277–287 (2001) ArticleCAS Google Scholar
Handel, M. et al. Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience89, 909–926 (1999) ArticleCAS Google Scholar
Brailov, I. et al. Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. Brain Res.872, 271–275 (2000) ArticleCAS Google Scholar
Ray, K. et al. Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila.. J. Cell Biol.147, 507–518 (1999) ArticleCAS Google Scholar
Han, Y. G., Kwok, B. H. & Kernan, M. J. Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. Curr. Biol.13, 1679–1686 (2003) ArticleCAS Google Scholar
Taipale, J. et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature406, 1005–1009 (2000) ArticleCASADS Google Scholar
Varga, Z. M. et al. Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development128, 3497–3509 (2001) CASPubMed Google Scholar
Chen, W., Burgess, S. & Hopkins, N. Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity. Development128, 2385–2396 (2001) CASPubMed Google Scholar
Barresi, M. J., Stickney, H. L. & Devoto, S. H. The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity. Development127, 2189–2199 (2000) CASPubMed Google Scholar
Wolff, C. et al. iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes Dev.18, 1565–1576 (2004) ArticleCAS Google Scholar
Wilbanks, A. M. et al. β-arrestin 2 regulates zebrafish development through the hedgehog signalling pathway. Science306, 2264–2267 (2004) ArticleCASADS Google Scholar
Chen, W. et al. Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2. Science306, 2257–2260 (2004) ArticleCASADS Google Scholar
Dawson, T. M. et al. β-adrenergic receptor kinase-2 and β-arrestin-2 as mediators of odorant-induced desensitization. Science259, 825–829 (1993) ArticleCASADS Google Scholar
Cooper, M. K., Porter, J. A., Young, K. E. & Beachy, P. A. Teratogen-mediated inhibition of target tissue response to Shh signalling. Science280, 1603–1607 (1998) ArticleCASADS Google Scholar