NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury (original) (raw)

References

  1. Back, S. A. et al. Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia. J. Neurosci. 22, 455–463 (2002)
    Article CAS Google Scholar
  2. Grossman, S. D., Rosenberg, L. J. & Wrathall, J. R. Temporal–spatial pattern of acute neuronal and glial loss after spinal cord contusion. Exp. Neurol. 168, 273–282 (2001)
    Article CAS Google Scholar
  3. Dewar, D., Underhill, S. M. & Goldberg, M. P. Oligodendrocytes and ischemic brain injury. J. Cereb. Blood Flow Metab. 23, 263–274 (2003)
    Article Google Scholar
  4. Pitt, D., Werner, P. & Raine, C. S. Glutamate excitotoxicity in a model of multiple sclerosis. Nature Med. 6, 67–70 (2000)
    Article CAS Google Scholar
  5. Brun, A. & Englund, E. A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann. Neurol. 19, 253–262 (1986)
    Article CAS Google Scholar
  6. Wilke, S., Salter, M., Thomas, R., Allcock, N. & Fern, R. Mechanism of acute ischemic injury of oligodendroglia in early myelinating white matter: the importance of astrocyte injury and glutamate release. J. Neuropathol. Exp. Neurol. 63, 872–881 (2004)
    Article CAS Google Scholar
  7. Ludwin, S. K. Pathology of demyelination and remyelination. Adv. Neurol. 31, 123–168 (1981)
    CAS PubMed Google Scholar
  8. Rodriguez, M., Scheithauer, B. W., Forbes, G. & Kelly, P. J. Oligodendrocyte injury is an early event in lesions of multiple sclerosis. Mayo Clin. Proc. 68, 627–636 (1993)
    Article CAS Google Scholar
  9. Wolswijk, G. Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis. Brain 123, 105–115 (2000)
    Article Google Scholar
  10. Back, S. A., Gan, X., Li, Y., Rosenberg, P. A. & Volpe, J. J. Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. J. Neurosci. 18, 6241–6253 (1998)
    Article CAS Google Scholar
  11. Fern, R. & Moller, T. Rapid ischemic cell death in immature oligodendrocytes: a fatal glutamate release feedback loop. J. Neurosci. 20, 34–42 (2000)
    Article CAS Google Scholar
  12. Follett, P. L., Rosenberg, P. A., Volpe, J. J. & Jensen, F. E. NBQX attenuates excitotoxic injury in developing white matter. J. Neurosci. 20, 9235–9241 (2000)
    Article CAS Google Scholar
  13. Gallo, V. & Ghiani, C. A. Glutamate receptors in glia: new cells, new inputs and new functions. Trends Pharmacol. Sci. 21, 252–258 (2000)
    Article CAS Google Scholar
  14. Itoh, T. et al. AMPA glutamate receptor-mediated calcium signalling is transiently enhanced during development of oligodendrocytes. J. Neurochem. 81, 390–402 (2002)
    Article CAS Google Scholar
  15. Small, R. K., Riddle, P. & Noble, M. Evidence for migration of oligodendrocyte–type-2 astrocyte progenitor cells into the developing rat optic nerve. Nature 328, 155–157 (1987)
    Article ADS CAS Google Scholar
  16. Craig, A. et al. Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human. Exp. Neurol. 181, 231–240 (2003)
    Article Google Scholar
  17. Butt, A. M. & Ransom, B. R. Morphology of astrocytes and oligodendrocytes during development in the intact rat optic nerve. J. Comp. Neurol. 338, 141–158 (1993)
    Article CAS Google Scholar
  18. Zhuo, L. et al. Live astrocytes visualized by green fluorescent protein in transgenic mice. Dev. Biol. 187, 36–42 (1997)
    Article CAS Google Scholar
  19. McDonald, J. W., Althomsons, S. P., Hyrc, K. L., Choi, D. W. & Goldberg, M. P. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nature Med. 4, 291–297 (1998)
    Article CAS Google Scholar
  20. Matute, C., Sanchez-Gomez, M. V., Martinez-Millan, L. & Miledi, R. Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes. Proc. Natl Acad. Sci. USA 94, 8830–8835 (1997)
    Article ADS CAS Google Scholar
  21. Salter, M. G., Franklin, K. A. & Whitelam, G. C. Gating of the rapid shade-avoidance response by the circadian clock in plants. Nature 426, 680–683 (2003)
    Article ADS CAS Google Scholar
  22. Alvarez, J., Giuditta, A. & Koenig, E. Protein synthesis in axons and terminals: significance for maintenance, plasticity and regulation of phenotype. With a critique of slow transport theory. Prog. Neurobiol. 62, 1–62 (2000)
    Article CAS Google Scholar
  23. Barres, B. A. et al. Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70, 31–46 (1992)
    Article CAS Google Scholar
  24. Káradóttir, R., Cavelier, P., Bergersen, L. H. & Attwell, D. NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature doi:10.1038/nature04302 (this issue)
  25. Matsuda, K., Kamiya, Y., Matsuda, S. & Yuzaki, M. Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability. Brain Res. Mol. Brain Res. 100, 43–52 (2002)
    Article CAS Google Scholar
  26. Sasaki, Y. F. et al. Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J. Neurophysiol. 87, 2052–2063 (2002)
    Article CAS Google Scholar
  27. Wang, C. et al. Functional _N_-methyl-D-aspartate receptors in O-2A glial precursor cells: a critical role in regulating polysialic acid–neural cell adhesion molecule expression and cell migration. J. Cell Biol. 135, 1565–1581 (1996)
    Article CAS Google Scholar
  28. Ziak, D., Chvatal, A. & Sykova, E. Glutamate-, kainate- and NMDA-evoked membrane currents in identified glial cells in rat spinal cord slice. Physiol. Res. 47, 365–375 (1998)
    CAS PubMed Google Scholar
  29. Yuan, X. et al. Expression of the green fluorescent protein in the oligodendrocyte lineage: a transgenic mouse for developmental and physiological studies. J. Neurosci. Res. 70, 529–545 (2002)
    Article CAS Google Scholar

Download references