Crypt stem cells as the cells-of-origin of intestinal cancer (original) (raw)
Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5 . Nature449, 1003-1007 (2007) ArticleADSCAS Google Scholar
Barker, N., van de Wetering, M. & Clevers, H. The intestinal stem cell. Genes Dev.22, 1856-1864 (2008) ArticleCAS Google Scholar
Potten, C. S. Kinetics and possible regulation of crypt cell populations under normal and stress conditions. Bull. Cancer62, 419-430 (1975) CASPubMed Google Scholar
Cheng, H. & Leblond, C. P. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am. J. Anat.141, 537-561 (1974) ArticleCAS Google Scholar
Cheng, H. & Leblond, C. P. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. Am. J. Anat.141, 461-479 (1974) ArticleCAS Google Scholar
Marshman, E., Booth, C. & Potten, C. S. The intestinal epithelial stem cell. Bioessays24, 91-98 (2002) Article Google Scholar
Bjerknes, M. & Cheng, H. The stem-cell zone of the small intestinal epithelium. II. Evidence from paneth cells in the newborn mouse. Am. J. Anat.160, 65-75 (1981) ArticleCAS Google Scholar
Bjerknes, M. & Cheng, H. The stem-cell zone of the small intestinal epithelium. I. Evidence from Paneth cells in the adult mouse. Am. J. Anat.160, 51-63 (1981) ArticleCAS Google Scholar
Ireland, H., Houghton, C., Howard, L. & Winton, D. J. Cellular inheritance of a Cre-activated reporter gene to determine Paneth cell longevity in the murine small intestine. Dev. Dyn.233, 1332-1336 (2005) ArticleCAS Google Scholar
Jones, S. et al. Comparative lesion sequencing provides insights into tumor evolution. Proc. Natl Acad. Sci. USA105, 4283-4288 (2008) ArticleADSCAS Google Scholar
Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell87, 159-170 (1996) ArticleCAS Google Scholar
Korinek, V. et al. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma. Science275, 1784-1787 (1997) ArticleCAS Google Scholar
Morin, P. J. et al. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science275, 1787-1790 (1997) ArticleCAS Google Scholar
van de Wetering, M. et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell111, 241-250 (2002) ArticleCAS Google Scholar
Van der Flier, L. G. et al. The intestinal Wnt/TCF signature. Gastroenterology132, 628-632 (2007) ArticleCAS Google Scholar
Sansom, O. J. et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev.18, 1385-1390 (2004) ArticleCAS Google Scholar
Shibata, H. et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science278, 120-123 (1997) ArticleCAS Google Scholar
Sansom, O. J. et al. Myc deletion rescues Apc deficiency in the small intestine. Nature446, 676-679 (2007) ArticleADSCAS Google Scholar
Sansom, O. J. et al. Cyclin D1 is not an immediate target of β-catenin following Apc loss in the intestine. J. Biol. Chem.280, 28463-28467 (2005) ArticleCAS Google Scholar
Muncan, V. et al. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol. Cell. Biol.26, 8418-8426 (2006) ArticleCAS Google Scholar
Batlle, E. et al. β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell111, 251-263 (2002) ArticleCAS Google Scholar
Cortina, C. et al. EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nature Genet.39, 1376-1383 (2007) ArticleCAS Google Scholar
Sangiorgi, E. & Capecchi, M. R. Bmi1 is expressed in vivo in intestinal stem cells. Nature Genet.40, 915-920 (2008) ArticleCAS Google Scholar
Harada, N. et al. Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene. EMBO J.18, 5931-5942 (1999) ArticleCAS Google Scholar
Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med.3, 730-737 (1997) ArticleCAS Google Scholar
Clarke, M. F. et al. Cancer stem cells—perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res.66, 9339-9344 (2006) ArticleCAS Google Scholar
Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA100, 3983-3988 (2003) ArticleADSCAS Google Scholar
O’Brien, C. A., Pollett, A., Gallinger, S. & Dick, J. E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature445, 106-110 (2007) ArticleADS Google Scholar
Ricci-Vitiani, L. et al. Identification and expansion of human colon-cancer-initiating cells. Nature445, 111-115 (2007) ArticleADSCAS Google Scholar
Dalerba, P. et al. Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl Acad. Sci. USA104, 10158-10163 (2007) ArticleADSCAS Google Scholar