Mechanism of differential control of NMDA receptor activity by NR2 subunits (original) (raw)
Dingledine, R., Borges, K., Bowie, D. & Traynelis, S. F. The glutamate receptor ion channels. Pharmacol. Rev.51, 7–61 (1999) CASPubMed Google Scholar
Kemp, J. A. & McKernan, R. M. NMDA receptor pathways as drug targets. Nature Neurosci.5 (Suppl.). 1039–1042 (2002) ArticleCAS Google Scholar
Paoletti, P. & Neyton, J. NMDA receptor subunits: function and pharmacology. Curr. Opin. Pharmacol.7, 39–47 (2007) ArticleCAS Google Scholar
Cull-Candy, S. G. & Leszkiewicz, D. N. Role of distinct NMDA receptor subtypes at central synapses. Sci. STKE2004, re16 (2004) PubMed Google Scholar
Chen, N., Luo, T. & Raymond, L. A. Subtype-dependence of NMDA receptor channel open probability. J. Neurosci.19, 6844–6854 (1999) ArticleCAS Google Scholar
Erreger, K., Dravid, S. M., Banke, T. G., Wyllie, D. J. & Traynelis, S. F. Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. J. Physiol. (Lond.)563, 345–358 (2005) ArticleCAS Google Scholar
Wyllie, D. J., Behe, P. & Colquhoun, D. Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors. J. Physiol. (Lond.)510, 1–18 (1998) ArticleCAS Google Scholar
Dravid, S. M., Prakash, A. & Traynelis, S. F. Activation of recombinant NR1/NR2C NMDA receptors. J. Physiol. (Lond.)586, 4425–4439 (2008) ArticleCAS Google Scholar
Popescu, G., Robert, A., Howe, J. R. & Auerbach, A. Reaction mechanism determines NMDA receptor response to repetitive stimulation. Nature430, 790–793 (2004) ArticleADSCAS Google Scholar
Liu, Y. et al. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo . J. Neurosci.27, 2846–2857 (2007) ArticleCAS Google Scholar
Liu, L. et al. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science304, 1021–1024 (2004) ArticleADSCAS Google Scholar
Paoletti, P. et al. Molecular organization of a zinc binding N-terminal modulatory domain in a NMDA receptor subunit. Neuron28, 911–925 (2000) ArticleCAS Google Scholar
Low, C. M., Zheng, F., Lyuboslavsky, P. & Traynelis, S. F. Molecular determinants of coordinated proton and zinc inhibition of _N_-methyl-d-aspartate NR1/NR2A receptors. Proc. Natl Acad. Sci. USA97, 11062–11067 (2000) ArticleADSCAS Google Scholar
Choi, Y. B. & Lipton, S. A. Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor. Neuron23, 171–180 (1999) ArticleCAS Google Scholar
Perin-Dureau, F., Rachline, J., Neyton, J. & Paoletti, P. Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors. J. Neurosci.22, 5955–5965 (2002) ArticleCAS Google Scholar
Jones, K. S., VanDongen, H. M. & VanDongen, A. M. The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening. J. Neurosci.22, 2044–2053 (2002) ArticleCAS Google Scholar
Yuan, H., Erreger, K., Dravid, S. M. & Traynelis, S. F. Conserved structural and functional control of _N_-methyl-d-aspartate receptor gating by transmembrane domain M3. J. Biol. Chem.280, 29708–29716 (2005) ArticleCAS Google Scholar
Blanke, M. L. & VanDongen, A. M. Constitutive activation of the _N_-methyl-d-aspartate receptor via cleft-spanning disulfide bonds. J. Biol. Chem.283, 21519–21529 (2008) ArticleCAS Google Scholar
Rachline, J., Perin-Dureau, F., Le Goff, A., Neyton, J. & Paoletti, P. The micromolar zinc-binding domain on the NMDA receptor subunit NR2B. J. Neurosci.25, 308–317 (2005) ArticleCAS Google Scholar
Gielen, M. et al. Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition. Neuron57, 80–93 (2008) ArticleCAS Google Scholar
Sun, Y. et al. Mechanism of glutamate receptor desensitization. Nature417, 245–253 (2002) ArticleADSCAS Google Scholar
Tang, C., Schwieters, C. D. & Clore, G. M. Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR. Nature449, 1078–1082 (2007) ArticleADSCAS Google Scholar
Kniazeff, J. et al. Locking the dimeric GABAB G-protein-coupled receptor in its active state. J. Neurosci.24, 370–377 (2004) ArticleCAS Google Scholar
Mony, L. et al. Structural basis of NR2B-selective antagonist recognition by _N_-methyl-d-aspartate receptors. Mol. Pharmacol.75, 60–74 (2009) ArticleCAS Google Scholar
Zheng, F. et al. Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nature Neurosci.4, 894–901 (2001) ArticleCAS Google Scholar
Marvin, J. S. & Hellinga, H. W. Manipulation of ligand binding affinity by exploitation of conformational coupling. Nature Struct. Biol.8, 795–798 (2001) ArticleCAS Google Scholar
Low, C. M. et al. Molecular determinants of proton-sensitive _N_-methyl-d-aspartate receptor gating. Mol. Pharmacol.63, 1212–1222 (2003) ArticleCAS Google Scholar
Lisman, J. E. et al. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci.31, 234–242 (2008) ArticleCAS Google Scholar
Furukawa, H., Singh, S. K., Mancusso, R. & Gouaux, E. Subunit arrangement and function in NMDA receptors. Nature438, 185–192 (2005) ArticleADSCAS Google Scholar
Paoletti, P., Ascher, P. & Neyton, J. High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J. Neurosci.17, 5711–5725 (1997) ArticleCAS Google Scholar
Erreger, K. & Traynelis, S. F. Zinc inhibition of rat NR1/NR2A _N_-methyl-d-aspartate receptors. J. Physiol. (Lond.)586, 763–778 (2008) ArticleCAS Google Scholar
Schorge, S., Elenes, S. & Colquhoun, D. Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits. J. Physiol. (Lond.)569, 395–418 (2005) ArticleCAS Google Scholar
Colquhoun, D. & Sigworth, F. J. in Single-channel Recording (eds Sakmann, B. & Neher, E.) 483–587 (Plenum, 1995) Book Google Scholar
Sigworth, F. J. & Sine, S. M. Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys. J.52, 1047–1054 (1987) ArticleCAS Google Scholar
Jackson, M. B., Wong, B. S., Morris, C. E., Lecar, H. & Christian, C. N. Successive openings of the same acetylcholine receptor channel are correlated in open time. Biophys. J.42, 109–114 (1983) ArticleCAS Google Scholar
Kunishima, N. et al. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature407, 971–977 (2000) ArticleADSCAS Google Scholar
Doyle, D. A. et al. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science280, 69–77 (1998) ArticleADSCAS Google Scholar