Macrophage elastase kills bacteria within murine macrophages (original) (raw)

• Green, G. M. & Kass, E. H. The role of the alveolar macrophage in the clearance of bacteria from the lung. J. Exp. Med. 119, 167–176 (1964)
  Article CAS Google Scholar
• Gordon, S. The macrophage: Past, present and future. Eur. J. Immunol. 37, S9–S17 (2007)
  Article CAS Google Scholar
• Shiloh, M. U. et al. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 10, 29–38 (1999)
  Article CAS Google Scholar
• Ganz, T. Oxygen-independent microbicidal mechanisms of phagocytes. Proc. Am. Assoc. Physicians 111, 390–395 (1999)
  Article CAS Google Scholar
• Selsted, M. E. & Ouellette, A. J. Defensins in granules of phagocytic and non-phagocytic cells. Trends Cell Biol. 5, 114–119 (1995)
  Article CAS Google Scholar
• Biggar, W. D. & Sturgess, J. M. Role of lysozyme in the microbicidal activity of rat alveolar macrophages. Infect. Immun. 16, 974–982 (1977)
  CAS PubMed PubMed Central Google Scholar
• del Cerro-Vadillo, E. et al. Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth. J. Immunol. 176, 1321–1325 (2006)
  Article Google Scholar
• Hiemstra, P. S., van den Barselaar, M. T., Roest, M., Nibbering, P. H. & van Furth, R. Ubiquicidin, a novel murine microbicidal protein present in the cytosolic fraction of macrophages. J. Leukoc. Biol. 66, 423–428 (1999)
  Article CAS Google Scholar
• Hiemstra, P. S. et al. Antimicrobial proteins of murine macrophages. Infect. Immun. 61, 3038–3046 (1993)
  CAS PubMed PubMed Central Google Scholar
• Shipley, J. M., Wesselschmidt, R. L., Kobayashi, D. K., Ley, T. J. & Shapiro, S. D. Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. Proc. Natl Acad. Sci. USA 93, 3942–3946 (1996)
  Article ADS CAS Google Scholar
• Hautamaki, R. D., Kobayashi, D. K., Senior, R. M. & Shapiro, S. D. Macrophage elastase is required for cigarette smoke-induced emphysema in mice. Science 277, 2002–2004 (1997)
  Article CAS Google Scholar
• Brinckerhoff, C. E. & Matrisian, L. M. Matrix metalloproteinases: a tail of a frog that became a prince. Nature Rev. Mol. Cell Biol. 3, 207–214 (2002)
  Article CAS Google Scholar
• Raza, S. L., Nehring, L. C., Shapiro, S. D. & Cornelius, L. A. Proteinase-activated receptor-1 regulation of macrophage elastase (MMP-12) secretion by serine proteinases. J. Biol. Chem. 275, 41243–41250 (2000)
  Article CAS Google Scholar
• Lijnen, H. R. et al. Temporal and topographic matrix metalloproteinase expression after vascular injury in mice. Thromb. Haemost. 81, 799–807 (1999)
  Article CAS Google Scholar
• Knauper, V. et al. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. J. Biol. Chem. 272, 7608–7616 (1997)
  Article CAS Google Scholar
• Tam, E. M., Moore, T. R., Butler, G. S. & Overall, C. M. Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in collagen triple helicase activities. J. Biol. Chem. 279, 43336–43344 (2004)
  Article CAS Google Scholar
• McQuibban, G. A. et al. Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. J. Biol. Chem. 276, 43503–43508 (2001)
  Article CAS Google Scholar
• McQuibban, G. A. et al. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science 289, 1202–1206 (2000)
  Article ADS CAS Google Scholar
• Gronski, T. J. et al. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase. J. Biol. Chem. 272, 12189–12194 (1997)
  Article CAS Google Scholar
• Belaaouaj, A. et al. Mice lacking neutrophil elastase reveal impaired host defense against gram-negative bacterial sepsis. Nature Med. 4, 615–618 (1998)
  Article CAS Google Scholar
• Belaaouaj, A., Kim, K. S. & Shapiro, S. D. Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase. Science 289, 1185–1188 (2000)
  Article ADS CAS Google Scholar
• Weinrauch, Y., Drujan, D., Shapiro, S., Weiss, J. & Zychlinsky, A. Neutrophil elastase targets virulence factors of enterobacteria. Nature 417, 91–94 (2002)
  Article ADS CAS Google Scholar
• Lehrer, R. I. & Ganz, T. Antimicrobial polypeptides of human neutrophils. Blood 76, 2169–2181 (1990)
  CAS PubMed Google Scholar
• Wilson, C. L. et al. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286, 113–117 (1999)
  Article CAS Google Scholar
• Vu, T. H. et al. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93, 411–422 (1998)
  Article CAS Google Scholar
• Li, Q., Park, P., Wilson, C. & Parks, W. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell 111, 635–646 (2002)
  Article CAS Google Scholar
• Curci, J. A., Liao, S., Huffman, M. D., Shapiro, S. D. & Thompson, R. W. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J. Clin. Invest. 102, 1900–1910 (1998)
  Article CAS Google Scholar
• Heymans, S. et al. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture by impairs therapeutic angiogenesis and causes cardiac failure. Nature Med. 5, 1135–1142 (1999)
  Article CAS Google Scholar
• Golubkov, V. S. et al. Membrane type-1 matrix metalloproteinase (MT1-MMP- exhibits an important intracellular cleavage function and causes chromosome instability. J. Biol. Chem. 280, 25079–25086 (2005)
  Article CAS Google Scholar
• Limb, G. A. et al. Matrix metalloprteinase-1 associates with intracellular organelles and confers resistance to laminin a/c degradation during apoptosis. Am. J. Pathol. 166, 1555–1563 (2005)
  Article CAS Google Scholar