Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein (original) (raw)
References
White, S. R. & Lauring, B. AAA+ ATPases: achieving diversity of function with conserved machinery. Traffic8, 1657–1667 (2007) ArticleCAS Google Scholar
Scholey, J. M. Intraflagellar transport. Annu. Rev. Cell Dev. Biol.19, 423–443 (2003) ArticleCAS Google Scholar
Merdes, A., Ramyar, K., Vechio, J. D. & Cleveland, D. W. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell87, 447–458 (1996) ArticleCAS Google Scholar
Akhmanova, A. & Hammer, J. A., III Linking molecular motors to membrane cargo. Curr. Opin. Cell Biol.22, 479–487 (2010) ArticleCAS Google Scholar
Chou, T. F. et al. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc. Natl Acad. Sci. USA108, 4834–4839 (2011) ArticleADSCAS Google Scholar
Hyman, J. M. et al. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc. Natl Acad. Sci. USA106, 14132–14137 (2009) ArticleADSCAS Google Scholar
Jiang, J. & Hui, C.-C. Hedgehog signaling in development and cancer. Dev. Cell15, 801–812 (2008) ArticleCAS Google Scholar
Goetz, S. C. & Anderson, K. V. The primary cilium: a signalling centre during vertebrate development. Nature Rev. Genet.11, 331–344 (2010) ArticleCAS Google Scholar
Humke, E. W., Dorn, K. V., Milenkovic, L., Scott, M. P. & Rohatgi, R. The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev.24, 670–682 (2010) ArticleCAS Google Scholar
Kim, J., Kato, M. & Beachy, P. A. Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc. Natl Acad. Sci. USA106, 21666–21671 (2009) ArticleADSCAS Google Scholar
Huangfu, D. & Anderson, K. V. Cilia and Hedgehog responsiveness in the mouse. Proc. Natl Acad. Sci. USA102, 11325–11330 (2005) ArticleADSCAS Google Scholar
Heald, R. et al. Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Nature382, 420–425 (1996) ArticleADSCAS Google Scholar
Gaglio, T., Dionne, M. A. & Compton, D. A. Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes. J. Cell Biol.138, 1055–1066 (1997) ArticleCAS Google Scholar
Young, A., Dictenberg, J. B., Purohit, A., Tuft, R. & Doxsey, S. J. Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes. Mol. Biol. Cell11, 2047–2056 (2000) ArticleCAS Google Scholar
Varma, D., Monzo, P., Stehman, S. A. & Vallee, R. B. Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignment. J. Cell Biol.182, 1045–1054 (2008) ArticleCAS Google Scholar
King, S. J., Brown, C. L., Maier, K. C., Quintyne, N. J. & Schroer, T. A. Analysis of the dynein-dynactin interaction in vitro and in vivo. Mol. Biol. Cell14, 5089–5097 (2003) ArticleCAS Google Scholar
Starr, D. A., Williams, B. C., Hays, T. S. & Goldberg, M. L. ZW10 helps recruit dynactin and dynein to the kinetochore. J. Cell Biol.142, 763–774 (1998) ArticleCAS Google Scholar
Yen, T. J., Li, G., Schaar, B. T., Szilak, I. & Cleveland, D. W. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature359, 536–539 (1992) ArticleADSCAS Google Scholar
Gross, S. P. et al. Interactions and regulation of molecular motors in Xenopus melanophores. J. Cell Biol.156, 855–865 (2002) ArticleCAS Google Scholar
Kim, H. et al. Microtubule binding by dynactin is required for microtubule organization but not cargo transport. J. Cell Biol.176, 641–651 (2007) ArticleCAS Google Scholar
Bouchard, P., Penningroth, S. M., Cheung, A., Gagnon, C. & Bardin, C. W. erythro-9-[3-(2-Hydroxynonyl)]adenine is an inhibitor of sperm motility that blocks dynein ATPase and protein carboxylmethylase activities. Proc. Natl Acad. Sci. USA78, 1033–1036 (1981) ArticleADSCAS Google Scholar
Arasaki, K., Tani, K., Yoshimori, T., Stephens, D. J. & Tagaya, M. Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells. Mol. Pharmacol.71, 454–460 (2007) ArticleCAS Google Scholar
Schliwa, M., Ezzell, R. M. & Euteneuer, U. Erythro-9-[3-(2-hydroxynonyl)]adenine is an effective inhibitor of cell motility and actin assembly. Proc. Natl Acad. Sci. USA81, 6044–6048 (1984) ArticleADSCAS Google Scholar
Park, S., Lee, D. K. & Yang, C. H. Inhibition of fos-jun-DNA complex formation by dihydroguaiaretic acid and in vitro cytotoxic effects on cancer cells. Cancer Lett.127, 23–28 (1998) ArticleCAS Google Scholar
Zhu, G. et al. Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. J. Med. Chem.49, 2063–2076 (2006) ArticleCAS Google Scholar
Maldonado, M. & Kapoor, T. M. Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation. Nature Cell Biol.13, 475–482 (2011) ArticleCAS Google Scholar
Woehlke, G. et al. Microtubule interaction site of the kinesin motor. Cell90, 207–216 (1997) ArticleCAS Google Scholar
Kapoor, T. M. & Mitchison, T. J. Allele-specific activators and inhibitors for kinesin. Proc. Natl Acad. Sci. USA96, 9106–9111 (1999) ArticleADSCAS Google Scholar
Hook, P. et al. Long range allosteric control of cytoplasmic dynein ATPase activity by the stalk and C-terminal domains. J. Biol. Chem.280, 33045–33054 (2005) Article Google Scholar
Taipale, J. et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature406, 1005–1009 (2000) ArticleADSCAS Google Scholar