A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response (original) (raw)

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Acknowledgements

This work is supported by the National Institutes of Health (CA122794, CA140594, CA137181, CA137008, CA147940, CA137008-01, 1U01CA141576, Lung SPORE P50CA090578), United against Lung Cancer Foundation, American Lung Association and Susan Spooner Research Fund.

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Authors and Affiliations

1. Department of Medicine, Harvard Medical School, Boston, 02115, Massachusetts, USA
   Zhao Chen, Hiromichi Ebi, Yan Liu, Chunxiao Xu, Pasi A. Jänne, Jeffrey A. Engelman & Kwok-Kin Wong
2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 02115, Massachusetts, USA
   Zhao Chen, Katherine Cheng, Zandra Walton, Yan Liu, Jing Ouyang, Peng Gao, Michele S. Woo, Chunxiao Xu, Masahiko Yanagita, Abigail Altabef, Catherine Yao, Mohit Butaney, David Jackman, Pasi A. Jänne & Kwok-Kin Wong
3. Ludwig Center at Dana-Farber/Harvard Cancer Center, Dana-Farber Cancer Institute, Boston, 02115, Massachusetts, USA
   Zhao Chen, Katherine Cheng, Zandra Walton, Yan Liu, Peng Gao, Chunxiao Xu, George D. Demetri & Kwok-Kin Wong
4. Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, 02115, Massachusetts, USA
   Yuchuan Wang, Tanya Tupper, Yanping Sun, Amy Saur & Andrew L. Kung
5. Department of Imaging, Dana-Farber Cancer Institute, Boston, 02115, Massachusetts, USA
   Yuchuan Wang, Yanping Sun & Mizuki Nishino
6. Department of Radiology, Brigham and Women’s Hospital, Boston, 02115, Massachusetts, USA
   Yuchuan Wang & Mizuki Nishino
7. Department of Medical Oncology, Massachusetts General Hospital Cancer Center, Boston, 02114, Massachusetts, USA
   Hiromichi Ebi, Nabeel Bardeesy & Jeffrey A. Engelman
8. Department of Molecular Pharmacology and Therapeutics, Oncology Institute, Loyola University Chicago Stritch School of Medicine, Maywood, 60153, Illinois, USA
   Takeshi Shimamura
9. Department of Statistics & Statistical Laboratory, Center for Survey Statistics & Methodology, Iowa State University, Ames, 50010, Iowa, USA
   Jie Li
10. Department of Pathology, Brigham and Women’s Hospital, Boston, 02115, Massachusetts, USA
    Shumei Wang, Charles Lee & Lucian R. Chirieac
11. Department of Pathology and Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, 75390, Texas, USA
    Yuji Nakada, Christopher G. Peña & Diego H. Castrillon
12. Department of Biostatistics and Computational Biology, Department of Biostatistics, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, 02115, Massachusetts, USA
    Yoko Franchetti
13. Translational Research Institute, The Scripps Research Institute, Jupiter, 33458, Florida, USA
    Michael D. Cameron
14. The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, North Carolina, USA
    D. Neil Hayes, Matthew D. Wilkerson, Patrick J. Roberts, Carrie B. Lee & Norman E. Sharpless
15. Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 02115, Massachusetts, USA
    Daniel B. Costa
16. Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, 02115, Massachusetts, USA
    Pasi A. Jänne & Kwok-Kin Wong
17. Department of Medicine and Pathology, Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 02115, Massachusetts, USA
    Pier Paolo Pandolfi
18. Department of Systems Biology, Harvard Medical School, Boston, 02115, Massachusetts, USA
    Lewis C. Cantley
19. Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, 02115, Massachusetts, USA
    Lewis C. Cantley
20. Department of Pediatric Oncology, Dana Farber Cancer Institute and Children’s Hospital, Boston, 02115, Massachusetts, USA
    Andrew L. Kung

Authors

1. Zhao Chen
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2. Katherine Cheng
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3. Zandra Walton
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4. Yuchuan Wang
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5. Hiromichi Ebi
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6. Takeshi Shimamura
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7. Yan Liu
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8. Tanya Tupper
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9. Jing Ouyang
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10. Jie Li
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11. Peng Gao
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12. Michele S. Woo
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13. Chunxiao Xu
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14. Masahiko Yanagita
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15. Abigail Altabef
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16. Shumei Wang
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17. Charles Lee
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18. Yuji Nakada
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19. Christopher G. Peña
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20. Yanping Sun
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21. Yoko Franchetti
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22. Catherine Yao
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23. Amy Saur
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24. Michael D. Cameron
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25. Mizuki Nishino
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26. D. Neil Hayes
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27. Matthew D. Wilkerson
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28. Patrick J. Roberts
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29. Carrie B. Lee
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30. Nabeel Bardeesy
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31. Mohit Butaney
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32. Lucian R. Chirieac
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33. Daniel B. Costa
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34. David Jackman
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35. Norman E. Sharpless
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36. Diego H. Castrillon
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37. George D. Demetri
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38. Pasi A. Jänne
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39. Pier Paolo Pandolfi
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40. Lewis C. Cantley
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41. Andrew L. Kung
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42. Jeffrey A. Engelman
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43. Kwok-Kin Wong
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Contributions

Z.C., K.C., Z.W., Y.W., H.E., T.S., Y.L., T.T., J.O., J.L., P.G., M.S.W., C.X., M.Y., A.A., S.W., C.L., Y.N., C.G.P., Y.S., Y.F., C.Y., A.S., M.D.C., D.N.H., M.D.W., P.J.R., C.B.L., N.B., N.E.S., D.H.C., G.D.D., P.A.J., L.C.C., C.B.L., M.N. and P.P.P. performed experimental work and data analyses. M.B., L.R.C., D.B.C. and D.J. collected data and provided patient materials. A.L.K., J.A.E. and K.-K.W. conceived and supervised all aspects of the project. All authors contributed to the final manuscript.

Corresponding authors

Correspondence toAndrew L. Kung, Jeffrey A. Engelman or Kwok-Kin Wong.

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Competing interests

N.H. and J.A.E. received research funding from AstraZenca. G.D.D. is a consultant of Champions Biotechnology. K.-K.W., N.E.S., P.A.J., N.B. and D.H.C. have filed a patent on LKB1 as a diagnostic biomarker in cancer. All other authors have no competing financial interest.

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Chen, Z., Cheng, K., Walton, Z. et al. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.Nature 483, 613–617 (2012). https://doi.org/10.1038/nature10937

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• Received: 11 August 2011
• Accepted: 09 February 2012
• Published: 18 March 2012
• Issue Date: 29 March 2012
• DOI: https://doi.org/10.1038/nature10937