Sorting out the sirtuins (original) (raw)

Ageing

Nature volume 483, pages 166–167 (2012)Cite this article

Subjects

Debates over the role of sirtuin proteins in ageing are maturing into functional assessments of the individual proteins. It seems that overexpression of a specific sirtuin can extend lifespan in male mice. See Letter p.218

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: Potential mechanisms of action of SIRT6 on longevity.

Notes

  1. *This article and the paper3 under discussion were published online on 22 February 2012.

References

  1. Kaeberlein, M., McVey, M. & Guarente, L. Genes Dev. 13, 2570–2580 (1999).
    Article CAS Google Scholar
  2. Finkel, T., Deng, C.-X. & Mostoslavsky, R. Nature 460, 587–590 (2009).
    Article ADS CAS Google Scholar
  3. Kanfi, Y. et al. Nature 483, 218–221 (2012).
    Article ADS CAS Google Scholar
  4. Weindruch, R. & Sohal, R. S. N. Engl. J. Med. 337, 986–994 (1997).
    Article CAS Google Scholar
  5. Bartke, A. Phil. Trans. R. Soc. Lond. B 366, 28–34 (2011).
    Article CAS Google Scholar
  6. Ladiges, W. et al. Aging Cell 8, 346–352 (2009).
    Article CAS Google Scholar
  7. Xiao, C. et al. J. Biol. Chem. 285, 36776–36784 (2010).
    Article CAS Google Scholar
  8. Guevara-Aguirre, J. et al. Sci. Transl. Med. 3, 70ra13 (2011).
    Article Google Scholar
  9. Muzumdar, R. et al. Aging Cell 7, 438–440 (2008).
    Article CAS Google Scholar
  10. Mao, Z. et al. Science 332, 1443–1446 (2011).
    Article ADS CAS Google Scholar
  11. Kawahara, T. L. A. et al. Cell 136, 62–74 (2009).
    Article CAS Google Scholar
  12. Zhong, L. et al. Cell 140, 280–293 (2010).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. David B. Lombard and Richard A. Miller are in the Department of Pathology and the Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, Michigan 48100-2200, USA.,
    David B. Lombard & Richard A. Miller

Authors

  1. David B. Lombard
    You can also search for this author inPubMed Google Scholar
  2. Richard A. Miller
    You can also search for this author inPubMed Google Scholar

Corresponding authors

Correspondence toDavid B. Lombard or Richard A. Miller.

Rights and permissions

About this article

Cite this article

Lombard, D., Miller, R. Sorting out the sirtuins.Nature 483, 166–167 (2012). https://doi.org/10.1038/nature10950

Download citation