Human gut microbiome viewed across age and geography (original) (raw)

Accession codes

Data deposits

DNA sequences have been deposited in MG-RAST (http://metagenomics.anl.gov/) under accession numbers ‘qiime:850’ for Illumina V4 16S rRNA data sets, and ‘qiime:621’ for fecal microbiome shotgun sequencing data sets.

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Acknowledgements

We thank S. Wagoner and J. Manchester for superb technical assistance, plus B. Muegge, A. Grimm, A. Hsiao, N. Griffin and P. Tarr for suggestions, and M. Ndao, T. Tinnin and R. Mkakosya for patient recruitment and/or technical assistance. This work was supported in part by grants from the National Institutes of Health (DK078669, T32-HD049338), St. Louis Children’s Discovery Institute (MD112009-201), the Howard Hughes Medical Institute, the Crohn’s and Colitis Foundation of America, and the Bill and Melinda Gates Foundation. Parts of this work used the Janus supercomputer, which is supported by National Science Foundation grant CNS-0821794, the University of Colorado, Boulder, the University of Colorado, Denver, and the National Center for Atmospheric Research.

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Authors and Affiliations

1. Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, 63108, Missouri, USA
   Tanya Yatsunenko, Federico E. Rey & Jeffrey I. Gordon
2. Department of Pediatrics, Washington University School of Medicine, St Louis, 63110, Missouri, USA
   Mark J. Manary, Indi Trehan & Barbara Warner
3. Department of Community Health, University of Malawi College of Medicine, Blantyre, Malawi
   Mark J. Manary
4. Department of Paediatrics and Child Health, University of Malawi College of Medicine, Blantyre, Malawi
   Indi Trehan
5. Department of Biology, University of Puerto Rico - Rio Piedras, Puerto Rico 00931-3360,
   Maria Gloria Dominguez-Bello
6. Venezuelan Institute of Scientific Research (IVIC), Carretera Panamericana, Km 11, Altos de Pipe, Venezuela,
   Monica Contreras
7. Amazonic Center for Research and Control of Tropical Diseases (CAICET), Puerto Ayacucho 7101, Amazonas, Venezuela,
   Magda Magris & Glida Hidalgo
8. Division of Gastroenterology and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, 19104, Pennsylvania, USA
   Robert N. Baldassano
9. Department of Psychiatry, Washington University School of Medicine, St Louis, 63110, Missouri, USA
   Andrey P. Anokhin & Andrew C. Heath
10. Department of Chemistry and Biochemistry, University of Colorado, Boulder, 80309, USA
    Jens Reeder, Justin Kuczynski, Catherine A. Lozupone, Christian Lauber, Jose Carlos Clemente, Dan Knights & Rob Knight
11. Department of Computer Science, Northern Arizona University, Flagstaff, 86001, Arizona, USA
    J. Gregory Caporaso
12. Howard Hughes Medical Institute, University of Colorado, Boulder, 80309, USA
    Rob Knight

Authors

1. Tanya Yatsunenko
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2. Federico E. Rey
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3. Mark J. Manary
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4. Indi Trehan
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5. Maria Gloria Dominguez-Bello
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6. Monica Contreras
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7. Magda Magris
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8. Glida Hidalgo
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9. Robert N. Baldassano
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10. Andrey P. Anokhin
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11. Andrew C. Heath
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12. Barbara Warner
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13. Jens Reeder
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14. Justin Kuczynski
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15. J. Gregory Caporaso
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16. Catherine A. Lozupone
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17. Christian Lauber
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18. Jose Carlos Clemente
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19. Dan Knights
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20. Rob Knight
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21. Jeffrey I. Gordon
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Contributions

T.Y., R.K. and J.I.G. designed the experiments, M.J.M., I.T., M.G.D.-B., M.C., M.M., G.H., A.C.H., A.P.A., R.K., R.N.B., C.A.L., C.L. and B.W. participated in patient recruitment, T.Y. generated the data, T.Y., F.E.R., J.R., J.K., J.G.C., J.C.C., D.K., R.K. and J.I.G. analysed the results, T.Y., R.K. and J.I.G. wrote the paper.

Corresponding author

Correspondence toJeffrey I. Gordon.

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The authors declare no competing financial interests.

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Supplementary Information

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Yatsunenko, T., Rey, F., Manary, M. et al. Human gut microbiome viewed across age and geography.Nature 486, 222–227 (2012). https://doi.org/10.1038/nature11053

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• Received: 25 February 2011
• Accepted: 20 March 2012
• Published: 09 May 2012
• Issue Date: 14 June 2012
• DOI: https://doi.org/10.1038/nature11053