AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress (original) (raw)

• Folkman, J. Angiogenesis and apoptosis. Semin. Cancer Biol. 13, 159–167 (2003)
  Article CAS Google Scholar
• Jones, R. G. & Thompson, C. B. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev. 23, 537–548 (2009)
  Article CAS Google Scholar
• Shackelford, D. B. & Shaw, R. J. The LKB1–AMPK pathway: metabolism and growth control in tumour suppression. Nature Rev. Cancer 9, 563–575 (2009)
  Article CAS Google Scholar
• Bardeesy, N. et al. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419, 162–167 (2002)
  Article CAS ADS Google Scholar
• Kato, K. et al. Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation. Oncogene 21, 6082–6090 (2002)
  Article CAS Google Scholar
• Laderoute, K. R. et al. 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol. Cell. Biol. 26, 5336–5347 (2006)
  Article CAS Google Scholar
• Chhipa, R. R., Wu, Y., Mohler, J. L. & Ip, C. Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress. Cell. Signal. 22, 1554–1561 (2010)
  Article CAS Google Scholar
• Corradetti, M. N., Inoki, K., Bardeesy, N., DePinho, R. A. & Guan, K. L. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz–Jeghers syndrome. Genes Dev. 18, 1533–1538 10.1101/gad.1199104. (2004)
• Shaw, R. J. et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl Acad. Sci. USA 101, 3329–3335 (2004)
  Article CAS ADS Google Scholar
• Jones, R. G. et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol. Cell 18, 283–293 (2005)
  Article CAS Google Scholar
• Le Goffe, C. et al. Metabolic control of resistance of human epithelial cells to H2O2 and NO stresses. Biochem. J. 364, 349–359 (2002)
  Article CAS Google Scholar
• Hardie, D. G. & Pan, D. A. Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase. Biochem. Soc. Trans. 30, 1064–1070 (2002)
  Article CAS Google Scholar
• Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. & Wakil, S. J. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 291, 2613–2616 (2001)
  Article CAS ADS Google Scholar
• Zhou, W. et al. Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 63, 7330–7337 (2003)
  CAS PubMed Google Scholar
• Canto, C. et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458, 1056–1060 (2009)
  Article CAS ADS Google Scholar
• Schafer, Z. T. et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 461, 109–113 (2009)
  Article CAS ADS Google Scholar
• Jang, T. et al. 5′-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat. Int. J. Cancer 128, 2230–2239 (2011)
  Article CAS Google Scholar
• Kim, H. S. et al. Microarray analysis of papillary thyroid cancers in Korean. Korean J. Intern. Med. 25, 399–407 (2010)
  Article CAS Google Scholar
• Zaugg, K. et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev. 25, 1041–1051 (2011)
  Article CAS Google Scholar
• Hatzivassiliou, G. et al. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 8, 311–321 (2005)
  Article CAS Google Scholar
• Migita, T. et al. Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. J. Natl. Cancer Inst. 101, 519–532 (2009)
  Article CAS Google Scholar
• Knowles, L. M., Yang, C., Osterman, A. & Smith, J. W. Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4. J. Biol. Chem. 283, 31378–31384 (2008)
  Article CAS Google Scholar
• Bandyopadhyay, S. et al. Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells. Cancer Res. 66, 5934–5940 (2006)
  Article CAS Google Scholar
• Wellen, K. E. et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076–1080 (2009)
  Article CAS ADS Google Scholar
• Migita, T. et al. ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer. Cancer Res. 68, 8547–8554 (2008)
  Article CAS Google Scholar
• Ji, H. et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 448, 807–810 (2007)
  Article CAS ADS Google Scholar
• Bhaskar, P. T. et al. mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3β inhibition. Mol. Cell. Biol. 29, 5136–5147 (2009)
  Article CAS Google Scholar
• Li, D. et al. A new G6PD knockdown tumor-cell line with reduced proliferation and increased susceptibility to oxidative stress. Cancer Biother. Radiopharm. 24, 81–90 (2009)
  Article CAS Google Scholar
• Budanov, A. V. & Karin, M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134, 451–460 10.1016/j.cell.2008.06.028. (2008)
• Skeen, J. E. et al. Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell 10, 269–280 (2006)
  Article CAS Google Scholar
• Kennedy, S. G. et al. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11, 701–713 (1997)
  Article CAS Google Scholar
• Wagner, T. C. & Scott, M. D. Single extraction method for the spectrophotometric quantification of oxidized and reduced pyridine nucleotides in erythrocytes. Anal. Biochem. 222, 417–426 (1994)
  Article CAS Google Scholar
• Zerez, C. R., Lee, S. J. & Tanaka, K. R. Spectrophotometric determination of oxidized and reduced pyridine nucleotides in erythrocytes using a single extraction procedure. Anal. Biochem. 164, 367–373 (1987)
  Article CAS Google Scholar
• Rahman, I., Kode, A. & Biswas, S. K. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nature Protocols 1, 3159–3165 (2006)
  Article CAS Google Scholar
• Buzzai, M. et al. The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene 24, 4165–4173 (2005)
  Article CAS Google Scholar
• Deberardinis, R. J., Lum, J. J. & Thompson, C. B. Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth. J. Biol. Chem. 281, 37372–37380 (2006)
  Article CAS Google Scholar