A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge (original) (raw)
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Acknowledgements
We would like to thank H. Mayberg, R. Malenka, L. Gunaydin, J. Mattis, I. Ellwood and I. Witten for helpful comments on the manuscript; I. Ellwood, I. Witten, R. Airan, L. Meltzer, M. Roy, V. Gradinaru, A. Andalman, T. Davidson, R. Durand, M. Bower and M. Carr for useful discussions; and all members of the K.D. laboratory for their support. We are grateful to S. Pak, C. Ramakrishnan and C. Perry for technical assistance. This work was supported by the Wiegers Family Fund (K.D.), NARSAD (M.R.W. and K.R.T.), Stanford Graduate Fellowship (A.S.), Samsung Scholarship (S.-Y.K.), Berry Foundation Fellowship (A.A.), NIMH (1F32MH088010-01, K.M.T.), and NIMH, NIDA, the DARPA REPAIR Program, the Keck Foundation, the McKnight Foundation, the Yu, Snyder, Tarlton and Alice Woo Foundations, and the Gatsby Charitable Foundation (K.D.).
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Authors and Affiliations
- Department of Bioengineering, Stanford University, Stanford, 94305, California, USA
Melissa R. Warden, Aslihan Selimbeyoglu, Julie J. Mirzabekov, Kimberly R. Thompson, Sung-Yon Kim, Avishek Adhikari, Kay M. Tye & Karl Deisseroth - Neurosciences Program, Stanford University, Stanford, 94305, California, USA
Aslihan Selimbeyoglu, Sung-Yon Kim & Karl Deisseroth - Bio-X Program, Stanford University, Stanford, 94305, California, USA
Maisie Lo - Department of Brain & Cognitive Sciences, Picower Institute for Learning & Memory, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA
Kay M. Tye - Department of Physiology, University of California San Francisco, San Francisco, 94143, California, USA
Loren M. Frank - W.M. Keck Center for Integrative Neuroscience, University of California San Francisco, San Francisco, 94143, California, USA
Loren M. Frank - Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, 94305, California, USA
Karl Deisseroth - CNC Program, Stanford University, Stanford, 94305, California, USA
Karl Deisseroth - Howard Hughes Medical Institute, Stanford University, Stanford, 94305, California, USA
Karl Deisseroth
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- Melissa R. Warden
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Contributions
M.R.W., L.M.F. and K.D. contributed to study design with assistance from A.S. and K.M.T. M.R.W., L.M.F. and K.D. contributed to data interpretation and manuscript revision. M.R.W., A.S., K.M.T., J.J.M., M.L., K.R.T., S-Y.K. and A.A. contributed to data collection. M.R.W. coordinated all experiments, developed the induction coil and forced swim test electrophysiology methods, and performed all behavioural and in vivo electrophysiology analyses. K.D. supervised all aspects of the project. M.R.W and K.D. wrote the paper.
Corresponding authors
Correspondence toMelissa R. Warden or Karl Deisseroth.
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Competing interests
M.R.W. and K.D. have disclosed these findings to the Stanford Office of Technology Licensing, which has filed a patent application for the possible use of the findings and methods in identifying new treatments for depression. All materials, methods and reagents remain freely available for academic and non-profit research in perpetuity through the Deisseroth optogenetics website (http://www.optogenetics.org).
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Warden, M., Selimbeyoglu, A., Mirzabekov, J. et al. A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge.Nature 492, 428–432 (2012). https://doi.org/10.1038/nature11617
- Received: 18 January 2012
- Accepted: 24 September 2012
- Published: 18 November 2012
- Issue Date: 20 December 2012
- DOI: https://doi.org/10.1038/nature11617