Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells (original) (raw)

• Bar-Sagi, D. & Feramisco, J. R. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. Science 233, 1061–1068 (1986)
  Article ADS CAS Google Scholar
• Porat-Shliom, N., Kloog, Y. & Donaldson, J. G. A unique platform for H-Ras signaling involving clathrin-independent endocytosis. Mol. Biol. Cell 19, 765–775 (2008)
  Article CAS Google Scholar
• Walsh, A. B. & Bar-Sagi, D. Differential activation of the Rac pathway by Ha-Ras and K-Ras. J. Biol. Chem. 276, 15609–15615 (2001)
  Article CAS Google Scholar
• Lopez-Crapez, E., Chypre, C., Saavedra, J., Marchand, J. & Grenier, J. Rapid and large-scale method to detect K-ras gene mutations in tumor samples. Clin. Chem. 43, 936–942 (1997)
  CAS PubMed Google Scholar
• Aoki, K., Yoshida, T., Sugimura, T. & Terada, M. Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity. Cancer Res. 55, 3810–3816 (1995)
  CAS PubMed Google Scholar
• Ivanov, A. I. Pharmacological inhibition of endocytic pathways: is it specific enough to be useful? Methods Mol. Biol. 440, 15–33 (2008)
  Article CAS Google Scholar
• West, M. A., Bretscher, M. S. & Watts, C. Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells. J. Cell Biol. 109, 2731–2739 (1989)
  Article CAS Google Scholar
• Capon, D. J., Chen, E. Y., Levinson, A. D., Seeburg, P. H. & Goeddel, D. V. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature 302, 33–37 (1983)
  Article ADS CAS Google Scholar
• Knowles, M. A. & Williamson, M. Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing. Cancer Res. 53, 133–139 (1993)
  CAS PubMed Google Scholar
• Wagner, M. et al. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. Genes Dev. 15, 286–293 (2001)
  Article CAS Google Scholar
• Hingorani, S. R. et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7, 469–483 (2005)
  Article CAS Google Scholar
• Nolan-Stevaux, O. et al. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev. 23, 24–36 (2009)
  Article CAS Google Scholar
• Stehle, G. et al. Plasma protein (albumin) catabolism by the tumor itself–implications for tumor metabolism and the genesis of cachexia. Crit. Rev. Oncol. Hematol. 26, 77–100 (1997)
  Article CAS Google Scholar
• Gaglio, D., Soldati, C., Vanoni, M., Alberghina, L. & Chiaradonna, F. Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts. PLoS ONE 4, e4715 (2009)
  Article ADS Google Scholar
• Matés, J. M. et al. Glutamine homeostasis and mitochondrial dynamics. Int. J. Biochem. Cell Biol. 41, 2051–2061 (2009)
  Article Google Scholar
• Reis, R. C., Sorgine, M. H. & Coelho-Sampaio, T. A novel methodology for the investigation of intracellular proteolytic processing in intact cells. Eur. J. Cell Biol. 75, 192–197 (1998)
  Article CAS Google Scholar
• Newsholme, E. A., Crabtree, B. & Ardawi, M. S. Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance. Q. J. Exp. Physiol. 70, 473–489 (1985)
  Article CAS Google Scholar
• Wu, M. C., Arimura, G. K. & Yunis, A. A. Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase. Int. J. Cancer 22, 728–733 (1978)
  Article CAS Google Scholar
• Gaglio, D. et al. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol. Syst. Biol. 7, 523 (2011)
  Article Google Scholar
• Metallo, C. M. et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481, 380–384 (2012)
  Article ADS CAS Google Scholar
• Hirai, H. & Varmus, H. E. SH2 mutants of c-src that are host-dependent for transformation are transdominant inhibitors of mouse-cell transformation by activated c-src. Genes Dev. 4, 2342–2352 (1990)
  Article CAS Google Scholar
• Kasahara, K. et al. Role of Src-family kinases in formation and trafficking of macropinosomes. J. Cell. Physiol. 211, 220–232 (2007)
  Article CAS Google Scholar
• Mettlen, M. et al. Src triggers circular ruffling and macropinocytosis at the apical surface of polarized MDCK cells. Traffic 7, 589–603 (2006)
  Article CAS Google Scholar
• Veithen, A., Cupers, P., Baudhuin, P. & Courtoy, P. J. v-Src induces constitutive macropinocytosis in rat fibroblasts. J. Cell Sci. 109, 2005–2012 (1996)
  CAS PubMed Google Scholar
• Bos, J. L. ras oncogenes in human cancer: a review. Cancer Res. 49, 4682–4689 (1989)
  CAS PubMed Google Scholar
• Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801–1806 (2008)
  Article ADS CAS Google Scholar
• Holm, E. et al. Substrate balances across colonic carcinomas in humans. Cancer Res. 55, 1373–1378 (1995)
  CAS PubMed Google Scholar
• Tsakraklides, V. & Bell, S. P. Dynamics of pre-replicative complex assembly. J. Biol. Chem. 285, 9437–9443 (2010)
  Article CAS Google Scholar
• Wise, D. R. et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc. Natl Acad. Sci. USA 105, 18782–18787 (2008)
  Article ADS CAS Google Scholar
• Antoniewicz, M. R., Kelleher, J. K. & Stephanopoulos, G. Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis. Anal. Chem. 79, 7554–7559 (2007)
  Article CAS Google Scholar
• Fernandez, C. A., Des Rosiers, C., Previs, S. F., David, F. & Brunengraber, H. Correction of 13C mass isotopomer distributions for natural stable isotope abundance. J. Mass Spectrom. 31, 255–262 (1996)
  Article ADS CAS Google Scholar