The AID enzyme induces class switch recombination in fibroblasts (original) (raw)
Honjo, T., Kinoshita, K. & Muramatsu, M. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu. Rev. Immunol.20, 165–196 (2002); published online 4 October 2001 (DOI 10.1146/annurev.immunol.20.081701.141316v4) ArticleCAS Google Scholar
Kinoshita, K. & Honjo, T. Linking class-switch recombination with somatic hypermutation. Nature Rev. Mol. Cell Biol.2, 493–503 (2001) ArticleCAS Google Scholar
Neuberger, M. S. & Milstein, C. Somatic hypermutation. Curr. Opin. Immunol.7, 248–254 (1995) ArticleCAS Google Scholar
Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell102, 553–563 (2000) ArticleCAS Google Scholar
Revy, P. et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell102, 565–575 (2000) ArticleCAS Google Scholar
Stavnezer, N. J. & Sirlin, S. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. EMBO J.5, 95–102 (1986) Article Google Scholar
Yancopoulos, G. D. et al. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. EMBO J.5, 3259–3266 (1986) ArticleCAS Google Scholar
Lee, C. G. et al. Quantitative regulation of class switch recombination by switch region transcription. J. Exp. Med.194, 365–374 (2001) ArticleCAS Google Scholar
Rolink, A., Melchers, F. & Andersson, J. The SCID but not the RAG-2 gene product is required for Sμ-Sɛ heavy chain class switching. Immunity5, 319–330 (1996) ArticleCAS Google Scholar
Casellas, R. et al. Ku80 is required for immunoglobulin isotype switching. EMBO J.17, 2404–2411 (1998) ArticleCAS Google Scholar
Manis, J. P. et al. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J. Exp. Med.187, 2081–2089 (1998) ArticleCAS Google Scholar
Muramatsu, M. et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem.274, 18470–18476 (1999) ArticleCAS Google Scholar
Petersen, S. et al. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching. Nature414, 660–665 (2001) ArticleADSCAS Google Scholar
Nakamura, M. et al. High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells. Int. Immunol.8, 193–201 (1996) ArticleCAS Google Scholar
Kinoshita, K., Tashiro, J., Tomita, S., Lee, C. G. & Honjo, T. Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. Immunity9, 849–858 (1998) ArticleCAS Google Scholar
Tashiro, J., Kinoshita, K. & Honjo, T. Palindromic but not G-rich sequences are targets of class switch recombination. Int. Immunol.13, 495–505 (2001) ArticleCAS Google Scholar
Chen, X., Kinoshita, K. & Honjo, T. Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination. Proc. Natl Acad. Sci. USA98, 13860–13865 (2001) ArticleADSCAS Google Scholar
Lupton, S. D., Brunton, L. L., Kalberg, V. A. & Overell, R. W. Dominant positive and negative selection using a hygromycin phosphotransferase–thymidine kinase fusion gene. Mol. Cell. Biol.11, 3374–3378 (1991) ArticleCAS Google Scholar
Kuzin, I. I. et al. Tetracyclines inhibit activated B cell function. Int. Immunol.13, 921–931 (2001) ArticleCAS Google Scholar
Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K. & Honjo, T. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Nature413, 639–643 (2001) ArticleADSCAS Google Scholar
Gu, H., Zou, Y. R. & Rajewsky, K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell73, 1155–1164 (1993) ArticleCAS Google Scholar
Jung, S., Rajewsky, K. & Radbruch, A. Shutdown of class switch recombination by deletion of a switch region control element. Science259, 984–987 (1993) ArticleADSCAS Google Scholar
Xu, L. et al. Replacement of germ-line e promoter by gene targeting alters control of immunoglobulin heavy chain class switching. Proc. Natl Acad. Sci. USA90, 3705–3709 (1993) ArticleADSCAS Google Scholar
Zhang, J., Bottaro, A., Li, S., Stewart, V. & Alt, F. W. A selective defect in IgG2b switching as a result of targeted mutation of the Iγ2b promoter and exon. EMBO J.12, 3529–3537 (1993) ArticleCAS Google Scholar
Dunnick, W., Hertz, G. Z., Scappino, L. & Gritzmacher, C. DNA sequences at immunoglobulin switch region recombination sites. Nucleic Acids Res.21, 365–372 (1993) ArticleCAS Google Scholar
Iwasato, T., Arakawa, H., Shimizu, A., Honjo, T. & Yamagishi, H. Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor β and lipopolysaccharide. J. Exp. Med.175, 1539–1546 (1992) ArticleCAS Google Scholar
Obata, M. et al. Structure of a rearranged γ 1 chain gene and its implication to immunoglobulin class-switch mechanism. Proc. Natl Acad. Sci. USA78, 2437–2441 (1981) ArticleADSCAS Google Scholar
Winter, E., Krawinkel, U. & Radbruch, A. Directed Ig class switch recombination in activated murine B cells. EMBO J.6, 1663–1671 (1987) ArticleCAS Google Scholar
Cubitt, A. B. et al. Understanding, improving and using green fluorescent proteins. Trends Biochem. Sci.20, 448–455 (1995) ArticleCAS Google Scholar
Kitamura, T. New experimental approaches in retrovirus-mediated expression screening. Int. J. Hematol.67, 351–359 (1998) ArticleCAS Google Scholar