Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells (original) (raw)

• Takeshita, S. et al. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J. Clin. Invest. 93, 662–670 (1994).
  Article CAS Google Scholar
• Gupta, R., Tongers, J. & Losordo, D.W. Human studies of angiogenic gene therapy. Circ. Res. 105, 724–736 (2009).
  Article CAS Google Scholar
• Losordo, D.W. & Dimmeler, S. Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines. Circulation 109, 2487–2491 (2004).
  Article Google Scholar
• Lekas, M., Lekas, P., Latter, D.A., Kutryk, M.B. & Stewart, D.J. Growth factor-induced therapeutic neovascularization for ischaemic vascular disease: time for a re-evaluation? Curr. Opin. Cardiol. 21, 376–384 (2006).
  Article Google Scholar
• Stewart, D.J. et al. VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: results of the NORTHERN trial. Mol. Ther. 17, 1109–1115 (2009).
  Article CAS Google Scholar
• Simons, M. Angiogenesis: where do we stand now? Circulation 111, 1556–1566 (2005).
  Article Google Scholar
• Suri, C. et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87, 1171–1180 (1996).
  Article CAS Google Scholar
• Murakami, M. & Simons, M. Regulation of vascular integrity. J. Mol. Med. 87, 571–582 (2009).
  Article Google Scholar
• Liu, H., Kennard, S. & Lilly, B. NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1. Circ. Res. 104, 466–475 (2009).
  Article CAS Google Scholar
• Tsigkou, O. et al. Engineered vascularized bone grafts. Proc. Natl. Acad. Sci. USA 107, 3311–3316 (2010).
  Article CAS Google Scholar
• Li, S. et al. Innate diversity of adult human arterial smooth muscle cells: cloning of distinct subtypes from the internal thoracic artery. Circ. Res. 89, 517–525 (2001).
  Article CAS Google Scholar
• Frontini, M.J. et al. Lipid incorporation inhibits Src-dependent assembly of fibronectin and type I collagen by vascular smooth muscle cells. Circ. Res. 104, 832–841 (2009).
  Article CAS Google Scholar
• Murakami, M. & Simons, M. Fibroblast growth factor regulation of neovascularization. Curr. Opin. Hematol. 15, 215–220 (2008).
  Article CAS Google Scholar
• Zhang, X. et al. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J. Biol. Chem. 281, 15694–15700 (2006).
  Article CAS Google Scholar
• Kuzuya, M. et al. Induction of apoptotic cell death in vascular endothelial cells cultured in three-dimensional collagen lattice. Exp. Cell Res. 248, 498–508 (1999).
  Article CAS Google Scholar
• Koyama, N., Hart, C.E. & Clowes, A.W. Different functions of the platelet-derived growth factor-alpha and -beta receptors for the migration and proliferation of cultured baboon smooth muscle cells. Circ. Res. 75, 682–691 (1994).
  Article CAS Google Scholar
• Hellstrom, M., Kalen, M., Lindahl, P., Abramsson, A. & Betsholtz, C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126, 3047–3055 (1999).
  CAS PubMed Google Scholar
• Chen, J.K., Taipale, J., Cooper, M.K. & Beachy, P.A. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 16, 2743–2748 (2002).
  Article CAS Google Scholar
• Schechner, J.S. et al. In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proc. Natl. Acad. Sci. USA 97, 9191–9196 (2000).
  Article CAS Google Scholar
• Mukouyama, Y.S., Shin, D., Britsch, S., Taniguchi, M. & Anderson, D.J. Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell 109, 693–705 (2002).
  Article CAS Google Scholar
• Lutolf, M.P. & Hubbell, J.A. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat. Biotechnol. 23, 47–55 (2005).
  Article CAS Google Scholar
• Benjamin, L.E., Hemo, I. & Keshet, E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 125, 1591–1598 (1998).
  CAS PubMed Google Scholar
• Cao, R. et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat. Med. 9, 604–613 (2003).
  Article CAS Google Scholar
• Naruo, K. et al. Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties. J. Biol. Chem. 268, 2857–2864 (1993).
  CAS PubMed Google Scholar
• Colvin, J.S., White, A.C., Pratt, S.J. & Ornitz, D.M. Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme. Development 128, 2095–2106 (2001).
  CAS PubMed Google Scholar
• Geske, M.J., Zhang, X., Patel, K.K., Ornitz, D.M. & Stappenbeck, T.S. Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development 135, 2959–2968 (2008).
  Article CAS Google Scholar
• Lavine, K. et al. Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev. 20, 1651–1666 (2006).
  Article CAS Google Scholar
• White, A.C., Lavine, K. & Ornitz, D. FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network. Development 134, 3743–3752 (2007).
  Article CAS Google Scholar
• Hung, I.H., Yu, K., Lavine, K. & Ornitz, D. FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Dev. Biol. 307, 300–313 (2007).
  Article CAS Google Scholar
• Korf-Klingebiel, M. et al. Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction. Circulation 123, 504–514 (2011).
  Article CAS Google Scholar
• Yi, L., Domyan, E.T., Lewandoski, M. & Sun, X. Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev. Dyn. 238, 123–137 (2009).
  Article CAS Google Scholar
• Miller, D.L., Ortega, S., Bashayan, O., Basch, R. & Basilico, C. Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice. Mol. Cell. Biol. 20, 2260–2268 (2000).
  Article CAS Google Scholar
• Zhou, M. et al. Fibroblast growth factor 2 control of vascular tone. Nat. Med. 4, 201–207 (1998).
  Article CAS Google Scholar
• Nissen, L.J. et al. Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J. Clin. Invest. 117, 2766–2777 (2007).
  Article CAS Google Scholar
• Yang, J. et al. Telomerized human microvasculature is functional in vivo. Nat. Biotechnol. 19, 219–224 (2001).
  Article CAS Google Scholar
• McKee, J.A. et al. Human arteries engineered in vitro. EMBO Rep. 4, 633–638 (2003).
  Article CAS Google Scholar
• Koike, N. et al. Tissue engineering: creation of long-lasting blood vessels. Nature 428, 138–139 (2004).
  Article CAS Google Scholar
• Li, S., Sims, S., Jiao, Y., Chow, L.H. & Pickering, J.G. Evidence from a novel human cell clone that adult vascular smooth muscle cells can convert reversibly between noncontractile and contractile phenotypes. Circ. Res. 85, 338–348 (1999).
  Article CAS Google Scholar
• Al-Shahrour, F., Diaz-Uriarte, R. & Dopazo, J. FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes. Bioinformatics 20, 578–580 (2004).
  Article CAS Google Scholar
• Dennis, G. Jr. et al. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 4, 3 (2003).
  Article Google Scholar
• Small, T.W. et al. Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. Circ. Res. 99, 1338–1346 (2006).
  Article CAS Google Scholar
• van der Veer, E. et al. Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation. Circ. Res. 97, 25–34 (2005).
  Article CAS Google Scholar
• Pickering, J.G. et al. Fibroblast growth factor-2 potentiates vascular smooth muscle cell migration to platelet-derived growth factor: upregulation of alpha2beta1 integrin and disassembly of actin filaments. Circ. Res. 80, 627–637 (1997).
  Article CAS Google Scholar
• Cawthon, R.M. Telomere measurement by quantitative PCR. Nucleic Acids Res. 30, e47 (2002).
  Article Google Scholar
• Limbourg, A. et al. Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Nat. Protoc. 4, 1737–1748 (2009).
  Article CAS Google Scholar
• Li, X. et al. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J. Clin. Invest. 115, 118–127 (2005).
  Article CAS Google Scholar
• Masocha, W. & Parvathy, S.S. Assessment of weight bearing changes and pharmacological antinociception in mice with LPS-induced monoarthritis using the Catwalk gait analysis system. Life Sci. 85, 462–469 (2009).
  Article CAS Google Scholar