Engineering pulmonary vasculature in decellularized rat and human lungs (original) (raw)

• Ott, H.C. et al. Regeneration and orthotopic transplantation of a bioartificial lung. Nat. Med. 16, 927–933 (2010).
  Article CAS Google Scholar
• Petersen, T.H. et al. Tissue-engineered lungs for in vivo implantation. Science 329, 538–541 (2010).
  Article CAS Google Scholar
• Herbert, S.P. & Stainier, D.Y.R. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat. Rev. Mol. Cell Biol. 12, 551–564 (2011).
  Article CAS Google Scholar
• Strilicć, B. et al. The molecular basis of vascular lumen formation in the developing mouse aorta. Dev. Cell 17, 505–515 (2009).
  Article Google Scholar
• Au, P., Tam, J., Fukumura, D. & Jain, R.K. Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood 111, 4551–4558 (2008).
  Article CAS Google Scholar
• Bayless, K.J., Salazar, R. & Davis, G.E. RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the αvβ3 and α5β1 integrins. Am. J. Pathol. 156, 1673–1683 (2000).
  Article CAS Google Scholar
• Kim, S.H. et al. Antagonism of VEGF-A–induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway. Blood 120, 4892–4902 (2012).
  Article CAS Google Scholar
• Förster, C. et al. Occludin as direct target for glucocorticoid-induced improvement of blood–brain barrier properties in a murine in vitro system. J. Physiol. (Lond.) 565, 475–486 (2005).
  Article Google Scholar
• Rock, J.R. et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc. Natl. Acad. Sci. USA 108, E1475–E1483 (2011).
  Article CAS Google Scholar
• Gavard, J. et al. A role for a CXCR2/phosphatidylinositol 3-kinase γ signaling axis in acute and chronic vascular permeability. Mol. Cell. Biol. 29, 2469–2480 (2009).
  Article CAS Google Scholar
• Carter, E.P., Ölveczky, B.P., Matthay, M.A. & Verkman, A.S. High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method. Biophys. J. 74, 2121–2128 (1998).
  Article CAS Google Scholar
• Baptista, P.M. et al. The use of whole organ decellularization for the generation of a vascularized liver organoid. Hepatology 53, 604–617 (2011).
  Article CAS Google Scholar
• Matthay, M.A., Folkesson, H.G. & Clerici, C. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev. 82, 569–600 (2002).
  Article CAS Google Scholar
• Mackersie, R.C., Christensen, J. & Lewis, F.R. The role of pulmonary lymphatics in the clearance of hydrostatic pulmonary edema. J. Surg. Res. 43, 495–504 (1987).
  Article CAS Google Scholar
• Melero-Martin, J.M. et al. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood 109, 4761–4768 (2007).
  Article CAS Google Scholar
• James, D. & et al. Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent. Nat. Biotechnol. 28, 161–166 (2010).
  Article CAS Google Scholar
• Stone, K., Mercer, R., Freeman, B., Chang, L. & Crapo, J. Distribution of lung cell numbers and volumes between alveolar and nonalveolar tissue. Am. Rev. Respir. Dis. 146, 454–456 (1992).
  Article CAS Google Scholar
• Crapo, J., Barry, B., Gehr, P., Bachofen, M. & Weibel, E. Cell number and cell characteristics of the normal human lung. Am. Rev. Respir. Dis. 126, 332–337 (1982).
  CAS PubMed Google Scholar
• Crisan, M. et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3, 301–313 (2008).
  Article CAS Google Scholar
• Meyrick, B. & Reid, L. The effect of continued hypoxia on rat pulmonary arterial circulation. An ultrastructural study. Lab. Invest. 38, 188–200 (1978).
  CAS PubMed Google Scholar
• Booth, A.J. et al. Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. Am. J. Respir. Crit. Care Med. 186, 866–876 (2012).
  Article CAS Google Scholar
• Nichols, J.E. et al. Production and assessment of decellularized pig and human lung scaffolds. Tissue Eng. Part A 19, 2045–2062 (2013).
  Article CAS Google Scholar
• Gilpin, S.E. et al. Perfusion decellularization of human and porcine lungs: bringing the matrix to clinical scale. J. Heart Lung Transplant. 33, 298–308 (2014).
  Article Google Scholar
• O′Neill, J.D. et al. Decellularization of human and porcine lung tissues for pulmonary tissue engineering. Ann. Thorac. Surg. 96, 1046–1055 (2013).
  Article Google Scholar
• Price, A.P. et al. Automated decellularization of intact, human-sized lungs for tissue engineering. Tissue Eng. Part C Methods 21, 94–103 (2015).
  Article CAS Google Scholar
• Wagner, D.E. et al. Comparative decellularization and recellularization of normal versus emphysematous human lungs. Biomaterials 35, 3281–3297 (2014).
  Article CAS Google Scholar
• Bonvillain, R.W. et al. Nonhuman primate lung decellularization and recellularization using a specialized large-organ bioreactor. J. Vis. Exp. e50825 (2013).
• Ott, H.C. et al. Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat. Med. 14, 213–221 (2008).
  Article CAS Google Scholar
• Song, J.J. et al. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat. Med. 19, 646–651 (2013).
  Article CAS Google Scholar
• Uygun, B.E. et al. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat. Med. 16, 814–820 (2010).
  Article CAS Google Scholar
• Salvagiotto, G. et al. A defined, feeder-free, serum-free system to generate in vitro hematopoietic progenitors and differentiated blood cells from hESCs and hiPSCs. PLoS ONE 6, e17829 (2011).
  Article CAS Google Scholar
• Sahara, M. et al. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 24, 820–841 (2014).
  Article CAS Google Scholar
• Prasain, N. et al. Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells. Nat. Biotechnol. 32, 1151–1157 (2014).
  Article CAS Google Scholar
• Huang, S.X.L. et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat. Biotechnol. 32, 84–91 (2014).
  Article CAS Google Scholar
• Longmire, T.A. et al. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell 10, 398–411 (2012).
  Article CAS Google Scholar
• Mou, H. et al. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell 10, 385–397 (2012).
  Article CAS Google Scholar
• Wong, A.P. et al. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat. Biotechnol. 30, 876–882 (2012).
  Article CAS Google Scholar
• Ghaedi, M. et al. Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix. J. Clin. Invest. 123, 4950–4962 (2013).
  Article CAS Google Scholar
• Ren, X. et al. Ex vivo non-invasive assessment of cell viability and proliferation in bio-engineered whole organ constructs. Biomaterials 52, 103–112 (2015).
  Article CAS Google Scholar