Intercellular delivery of functional p53 by the herpesvirus protein VP22 (original) (raw)

References

  1. Verma, I. and Somia, N. 1997. Gene therapy-problems, promises and prospects. Nature 389: 239–242.
    Article CAS PubMed Google Scholar
  2. Elliott, G. and O'Hare, P. 1997. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88: 223–233.
    Article CAS PubMed Google Scholar
  3. Levine, A.J. 1997. P53, the cellular gatekeeper for growth and division. Cell 88: 323–331.
    Article CAS PubMed Google Scholar
  4. Diller, L., Kassel, J., Nelson, C.E., Gryka, M.A., Litwak, G., Gebhardt, M. et al. 1990. P53 functions as a cell cycle control protein in osteosarcomas. Mol. Cell Biol. 10: 5772–5781.
    Article CAS PubMed PubMed Central Google Scholar
  5. Pientenpol, J.A. 1994. Sequence specific transcriptional transactivation is essential for growth suppression by p53. Proc. Natl. Acad. Sci. USA 91: 1998–2002.
    Article Google Scholar
  6. Baker, S.J., Markowitz, S., Fearon, E.R., Willson, J.K.V. and Vogelstein, B. 1990. Suppression of human colorectal carcinoma cell growth by wild type p53. Science 249: 912–915.
    Article CAS PubMed Google Scholar
  7. Hamada, K., Alemany, R., Zhang, W.-W., Hittelman, W.N., Lotan, R., Roth, J.A. and Mitchell, M.F. 1996. Adenovirus-mediated transfer of a wild type p53 gene and induction of apoptosis in cervical cancer. Cancer Res. 56: 3047–3054.
    CAS PubMed Google Scholar
  8. Nielsen, L.L., Dell, J., Maxwell, E., Armstrong, L., Maneval, D. and Catino, J.J. 1997. Efficacy of p53 adenovirus mediated gene therapy against human breast cancer xenografts. Cancer Gene Ther. 4: 129–138.
    CAS PubMed Google Scholar
  9. Xu, M., Kumar, X.M., Srinivas, S., Detolla, L.J., Yu, S.F., Stass, S.A. and Mixson, A.J. 1997. Parental gene therapy with p53 inhibits human breast cancer tumors in vivo through a bystander effect without evidence of toxicity. Hum. Gene Ther. 8: 177–185.
    Article CAS PubMed Google Scholar
  10. Roth, J.A. 1996. Retrovirus-mediated wild type p53 gene transfer to tumors of patients with lung cancer. Nat. Med. 2: 985–991.
    Article CAS PubMed Google Scholar
  11. Cai, D.W. 1993. Stable expression of the wild type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer. Hum. Gene Ther. 4: 617–624.
    Article CAS PubMed Google Scholar
  12. Sandig, V, Brand, K., Herwig, S., Lukas, J., Bartek, J. and Strauss, S. 1997. Adenovirally transferred p16 and p53 genes cooperate to induce apoptotic tumor death. Nat. Med. 3: 313–319.
    Article CAS PubMed Google Scholar
  13. Qazilbash, M.H., Xiao, X., Seth, P., Cowan, K.H. and Walsh, C.E. 1997. Cancer gene therapy using a novel adeno-associated virus vector expressing human wild type p53. Gene Ther. 4: 675–682.
    Article CAS PubMed Google Scholar
  14. Mesnil, M., Piccoli, C., Tiraby, G., Willecke, K. and Yamasaki, H. 1996. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc. Natl. Acad. Sci. USA 93: 1831–1835.
    Article CAS PubMed PubMed Central Google Scholar
  15. Elliott, G.D. and Meredith, D. 1994. The herpes simplex virus type 1 tegument protein VP22 is encoded by gene UL49. J. Gen. Virol. 73: 723–726.
    Article Google Scholar
  16. Leslie, J., Rixon, F., McLauchlan, J. 1997. Overexpression of the herpes simplex virus type 1 tegument protein VP22 increases its incorporation into virus particles. Virology 220: 60–68.
    Article Google Scholar
  17. McLauchlan, J., Liefkins, K. and Stow, N.D. 1994. The herpes simplex virus type 1 UL37 gene product is a component of virus particles. J. Gen. Virol. 75: 2047–2052.
    Article CAS PubMed Google Scholar
  18. Harlow, E., Crawford, L.V., Pirn, D.C. and Williamson, N.M. 1981. Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol. 39: 861–869.
    CAS PubMed PubMed Central Google Scholar

Download references