Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry (original) (raw)

References

1. Blackburn, E.H. and Greider, C.W. (eds.). 1995. Telomeres. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
   Google Scholar
2. Harley, C.B., Futcher, A.B. and Greider, C.W. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345: 458–460.
   Article CAS PubMed Google Scholar
3. Allsopp, R.C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E.V., Futcher, A.B. et al. 1992. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA 89: 10114–10118.
   Article CAS PubMed PubMed Central Google Scholar
4. Hastie, N.D., Dempster, M., Dunlop, M.G., Thompson, A.M., Green, D.K. and Allshire, R.C. 1990. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346: 866–868.
   Article CAS PubMed Google Scholar
5. Vaziri, H., Schachter, F., Uchida, I., Wei, L., Zhu, X., Effros, R. et al. 1993. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 52: 661–667.
   CAS PubMed PubMed Central Google Scholar
6. Greider, C.W. and Blackburn, E.H. 1985. Identification of a specific telomere terminal transferase activity in Tetrhymena extracts. Cell 43: 405–413.
   Article CAS PubMed Google Scholar
7. Lingner, J., Hughes, T.R., Shevchenko, A., Mann, M., Lundblad, V. and Cech, T.R. 1997. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276: 561–567.
   Article CAS PubMed Google Scholar
8. Blasco, M.A., Lee, H.-W., Hande, M.P., Samper, E., Lansdorp, P.M., DePinho, R.A. et al. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25–34.
   Article CAS PubMed Google Scholar
9. Autexier, C. and Greider, C.W. 1996. Telomerase and cancer: revisiting the telomere hypothesis. Trends. Biochem. Sci. 21: 387–391.
   Article CAS PubMed Google Scholar
10. Shay, J.W. and Wright, W.E. 1996. Telomerase activity in human cancer. Curr. Opin. Oncol. 8: 66–71.
    Article CAS PubMed Google Scholar
11. Bodnar, A.G., Ouellette, M., Frolkis, M., Holt, S.E., Chiu, C.-P., Morin, G.B. et al. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349–353.
    Article CAS PubMed Google Scholar
12. Vaziri, H. and Benchimol, S. 1998. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Blol. 8: 279–282.
    Article CAS Google Scholar
13. Martens, U.M., Zijlmans, J.M., Poon, S.S.S., Dragowska, W., Yui, J., Chavez, E.A. et al. 1998. Short telomeres on human chromosome 17p. Nat. Genet. 18: 76–80.
    Article CAS PubMed Google Scholar
14. Slagboom, R.E., Droog, S. and Boomsma, D.I. 1994. Genetic determination of telomere size in humans: a twin study of three age groups. Am. J. Hum. Genet. 55: 876–882.
    CAS PubMed PubMed Central Google Scholar
15. Weng, N.-R., Levine, B.L., June, C.H. and Hodes, R.J. 1995. Human naive and memory T lymphocytes differ in telomeric length and replictive potential. Proc. Natl. Acad. Sci. USA 92: 11091–11094.
    Article CAS PubMed PubMed Central Google Scholar
16. Vaziri, H., Dragowska, W., Allsopp, R.C., Thomas, T.E., Harley, C.B. and Lansdorp, P.M. 1994. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc. Natl. Acad. Sci. USA 91: 9857–9860.
    Article CAS PubMed PubMed Central Google Scholar
17. Notaro, R., Cimmino, A., Tabarini, D., Rotoli, B. and Luzzatto, L. 1997. In vivo telomere dynamics of human hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 94: 13782–13785.
    Article CAS PubMed PubMed Central Google Scholar
18. Wynn, R.F., Cross, M.A., Hatton, C., Will, A.M., Lashford, L.S., Dexter, T.M. et al. 1998. Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants. Lancet 351: 178–181.
    Article CAS PubMed Google Scholar
19. Wolthers, K.C., Wisman, B.G., Otto, S.A. de Roda Husman, A.M., Schaft, N., de Wolf, F. et al. 1996. T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover. Science 274: 1543–1547.
    Article CAS PubMed Google Scholar
20. Mohri, H., Bonhoeffer, S., Monard, S., Perelson, A.S. and Ho, D.D. 1998. Rapid turnover of T lymphocytes in SIV-infected rhesus macaques. Science 279: 1223–1227.
    Article CAS PubMed Google Scholar
21. Effros, R.B. and Pawelec, G. 1997. Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion. Immunol. Today 18: 450–454.
    Article CAS PubMed Google Scholar
22. Weng, N.-R., Palmer, L.D., Levine, B.L., Lane, H.C., June, C.H. and Hodes, R.J. 1997. Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol. Rev. 160: 43–54.
    Article CAS PubMed Google Scholar
23. Lansdorp, P.M., Verwoerd, N.P., van de Rijke, F.M., Dragowska, V., Little, M.-T., Dirks, R.W. et al. 1996. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5: 685–691.
    Article CAS PubMed Google Scholar
24. Smith, S.H., Brown, M.H., Rowe, D., Callard, R.E. and Beverley, R.C. 1986. Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL-1. Immunology 58: 63–70.
    CAS PubMed PubMed Central Google Scholar
25. Hamann, D., Baars, P.A., Rep, M.H.G., Hooibrink, B., Kerkhof-Garde, S.R., Klein, M.R. et al. 1997. Phenotypic and functional separation of memory and effector human CD8+ T cells. J. Exp. Med. 186: 1407–1418.
    Article CAS PubMed PubMed Central Google Scholar
26. Tough, D.F. and Sprent, J. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179: 1127–1135.
    Article CAS PubMed Google Scholar
27. Palmer, L.D., Weng, N.-R., Levine, B.L., June, C.H., Lane, H.C. and Hodes, R.J. 1997. Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins. J. Exp. Med. 185: 1381–1386.
    Article CAS PubMed PubMed Central Google Scholar
28. Trask, B., Van Den Engh, G., Landegent, J. Jansen in de Wai, N., and van der Ploeg, M. 1985. Detection of DNA sequences in nuclei in suspension by in situ hybridization and dual beam flow cytometry. Science 230: 1401–1403.
    Article CAS PubMed Google Scholar
29. Trask, B., Van Den Engh, G., Pinkel, D., Mullikin, J., Waldman, P., van Dekken, H et al. 1988. Fluorescence in situ hybridization to interphase cell nuclei in suspension allows flow cytometric analysis of chromosome content and microscopic analysis of nuclear organization. Hum. Genet. 78: 251–259.
    Article CAS PubMed Google Scholar
30. van Dekken, H., Arkesteijn, G.J.A., Visser, J.W.M. and Bauman, J.G.J. 1990.Flow cytometric quantification of human chromosome specific repetitive DNA sequences by single and bicoior fluorescent in situ hybridization to lymphocyte interphase nuclei. Cytometry 11: 153–164.
    Article CAS PubMed Google Scholar
31. Arkesteijn, G.J.A., Erpelinck, S.L.A., Martens, A.C.M. and Hagenbeek, A. 1995. Chromosome specific DNA hybridization in suspension for flow cytometric detection of chimerism in bone marrow transplantation and leukemia. Cytometry 19: 353–360.
    Article CAS PubMed Google Scholar
32. Yu, G. and Blackburn, E.H. 1991. Developmentally programmed healing of chromosomes by telomerase in Tetrahymena. Cell 67: 823–832.
    Article CAS PubMed Google Scholar
33. Cao, J., Vescio, R.A., Hong, C.H., Kim, A., Lichtenstein, A.K. and Berenson, J.R. 1995. Identification of malignant cells in multiple myeloma bone marrow with immunoglobulin VH gene probes by fluorescent in situ hybridization and flow cytometry. J. Clin. Invest. 95: 964–972.
    Article CAS PubMed PubMed Central Google Scholar
34. Zhu, X., Kumar, R., Mandal, M., Sharma, N., Sharma, H.W., Dhingra, U. et al. 1996. Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc. Natl. Acad. Sci. USA 93: 6091–6095.
    Article CAS PubMed PubMed Central Google Scholar
35. Nielsen, P.E., Egholm, M., Berg, R.H. and Buchardt, O. 1991. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science 254: 1497–1500.
    Article CAS PubMed Google Scholar
36. Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S., Driver, D.A. et al. 1993. PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen bonding rules. Nature 365: 566–568.
    Article CAS PubMed Google Scholar
37. ZijImans, J.M., Martens, U.M., Poon, S.S.S., Raap, A.K., Tanke, H.J., Ward, R.K. et al. 1997. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc. Natl. Acad. Sci. USA 94: 7423–7428.
    Article Google Scholar
38. Roosnek, E. and Lanzavecchia, A. 1989. Triggering T cells by otherwise inert hybrid anti-CD3/antitumor antibodies requires encounter with the specific target cell. J. Exp. Med. 170: 297–302.
    Article CAS PubMed Google Scholar

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