In vitro differentiation of transplantable neural precursors from human embryonic stem cells (original) (raw)
Thomson, J.A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145–1147 (1998). ArticleCASPubMed Google Scholar
Reubinoff, B.E., Pera, M.F., Fong, C.-F., Trounson, A. & Bongso, A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat. Biotechnol. 18, 399–404 (2000). ArticleCASPubMed Google Scholar
Thomson, J.A. & Odorico, J.S. Human embryonic stem cell and embryonic germ cell lines. Trends Biotechnol. 18, 53–57 (2000). ArticleCASPubMed Google Scholar
Amit, M. et al. Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev. Biol. 227, 271–278 (2000). ArticleCASPubMed Google Scholar
Wiles, M.V. & Keller, G. Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture. Development 111, 259–267 (1991). CASPubMed Google Scholar
Klug, M.G., Soonpaa, M.H., Koh, G.Y. & Field, L.J. Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J. Clin. Invest. 98, 216–224 (1996). ArticleCASPubMedPubMed Central Google Scholar
Soria, B. et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49, 157–162 (2000). ArticleCASPubMed Google Scholar
Bain, G., Kitchens, D., Yao, M., Huettner, J.E. & Gottlieb, D.I. Embryonic stem cells express neuronal properties in vitro. Dev. Biol. 168, 342–357 (1995). ArticleCASPubMed Google Scholar
Okabe, S., Forsberg-Nilsson, K., Spiro, A.C., Segal, M. & McKay, R.D.G. Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech. Dev. 59, 89–102 (1996). ArticleCASPubMed Google Scholar
Mujtaba, T. et al. Lineage-restricted neural precursors can be isolated from both the mouse neural tube and cultured ES cells. Dev. Biol. 214, 113–127 (1999). ArticleCASPubMed Google Scholar
Brustle, O. et al. Embryonic stem cell–derived glial precursors: a source of myelinating transplants. Science 285, 754–756 (1999). ArticleCASPubMed Google Scholar
Brustle, O. et al. _In vitro_–generated neural precursors participate in mammalian brain development. Proc. Natl. Acad. Sci. USA 94, 14809–14814 (1997). ArticleCASPubMedPubMed Central Google Scholar
McDonald, J.W. et al. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat. Med. 5, 1410–1412 (1999). ArticleCASPubMed Google Scholar
Zhang, S.-C., Ge, B. & Duncan, I.D. Tracing human oligodendroglial development in vitro. J. Neurosci. Res. 59, 421–429 (2000). ArticleCASPubMed Google Scholar
Zhang, S.-C., Ge, B. & Duncan, I.D. Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity. Proc. Natl. Acad. Sci. USA 96, 4089–4094 (1999). ArticleCASPubMedPubMed Central Google Scholar
Lendahl, U., Zimmerman, L.B. & McKay, R.D. CNS stem cells express a new class of intermediate filament protein. Cell 60, 585–595 (1990). ArticleCASPubMed Google Scholar
Kaneko, Y. et al. Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev. Neurosci. 22, 139–153 (2000). ArticleCASPubMed Google Scholar
Svendsen, C.N., Clarke, D.J., Rosser, A.E. & Dunnett, S.B. Survival and differentiation of rat and human epidermal growth factor–responsive precursor cells following grafting into the lesioned adult central nervous system. Exp. Neurol. 137, 376–388 (1996). ArticleCASPubMed Google Scholar
Carpenter, M.K. et al. In vitro expansion of a multipotent population of human neural progenitor cells. Exp. Neurol. 158, 265–278 (1999). ArticleCASPubMed Google Scholar
Vescovi, A.L. et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Exp. Neurol. 156, 71–83 (1999). ArticleCASPubMed Google Scholar
Flax, J.D. et al. Engraftable human neural stem cells respond to developmental cues, replace neurons and express foreign genes. Nat. Biotechnol. 16, 1033–1039 (1998). ArticleCASPubMed Google Scholar
Svendsen, C.N., Caldwell, M.A. & Ostenfeld, O. Human neural stem cells: isolation, expansion and transplantation. Brain Pathol. 9, 499–513 (1999). ArticleCASPubMed Google Scholar
Fricker, R.A. et al. Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain. J. Neurosci. 19, 5990–6005 (1999). CASPubMedPubMed Central Google Scholar
Brustle, O. et al. Chimeric brains generated by intraventricular transplantation with human brain cells into embryonic rats. Nat. Biotechnol. 16, 1040–1044 (1998). ArticleCASPubMed Google Scholar
Kalyani, A.D., Hobson, K. & Rao, M.S. Neuroepithelial stem cells from the embryonic spinal cord: isolation, characterization and clonal analysis. Dev. Biol. 186, 202–223 (1997). ArticleCASPubMed Google Scholar
Tropepe, V. et al. Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev. Biol. 208, 166–188 (1999). ArticleCASPubMed Google Scholar