Hsp90 invades the outside (original) (raw)

Nature Cell Biology volume 6, pages 479–480 (2004)Cite this article

Metalloproteases are required for the invasive nature of cancer cells. Surprisingly, the cytosolic molecular chaperone Hsp90 is now shown to promote maturation of the extracellular metalloprotease MMP2. This finding extends the multiplicity of roles assigned to the Hsp90 family to a new function outside the cell.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

$209.00 per year

only $17.42 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: The Hsp90 connection.

References

  1. Eustace, B.K. et al. Nature Cell Biol. 6, 507–510 (2004).
    Article CAS Google Scholar
  2. Beck, S. et al. Proteomics 2, 247–255 (2002).
    Article CAS Google Scholar
  3. Picard, D. Cell. Mol. Life Sci. 59, 1640–1648 (2002).
    Article CAS Google Scholar
  4. Neckers, L. & Ivy, S.P. Curr. Opin. Oncol. 15, 419–424 (2003).
    Article CAS Google Scholar
  5. Kamal, A. et al. Nature 425, 407–410 (2003).
    Article CAS Google Scholar
  6. Tsan, M.F. & Gao, B. Am. J. Physiol. Cell Physiol. 286, C739–C744 (2004).
    Article CAS Google Scholar
  7. Liao, D.F. et al. J. Biol. Chem. 275, 189–196 (2000).
    Article CAS Google Scholar
  8. Triantafilou, K., Triantafilou, M. & Dedrick, R.L. Nature Immunol. 2, 338–345 (2001).
    Article CAS Google Scholar
  9. Triantafilou, K. et al. J. Cell Sci. 114, 2535–2545 (2001).
    CAS PubMed Google Scholar
  10. Joseph, K., Tholanikunnel, B.G. & Kaplan, A.P. Proc. Natl Acad. Sci. USA 99, 896–900 (2002).
    Article CAS Google Scholar
  11. Wiech, H., Buchner, J., Zimmermann, R. & Jakob, U. Nature 358, 169–170 (1992).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. Département de Biologie Cellulaire, Université de Genève, Sciences III, 30, quai Ernest-Ansermet, Genève, 4, CH - 1211, Switzerland
    Didier Picard

Authors

  1. Didier Picard
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Picard, D. Hsp90 invades the outside.Nat Cell Biol 6, 479–480 (2004). https://doi.org/10.1038/ncb0604-479

Download citation

This article is cited by