Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis (original) (raw)

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Acknowledgements

We thank K. Kubota for excellent secretarial assistance. We are grateful to H. Murayama and S. Sato for critical discussion and excellent bone analysis, including microCT and histology. We are also grateful to N. Yamamoto, H. Takayanagi, T. Nakano, I. Ishikawa, H. Arase, N. Yamada, T. Kaisho and K. Hoshino for providing materials, critical advice, discussion and encouragement. We also thank T. Yazawa, A. Kawai, J. Yoshida, K Shiozaki, N. Okita, N. Iwami and K. Nakamura for technical support. This study was supported by research grants from the Ministry of Education, Culture, Sports, Science and Technology, Japan and from the Core Research for Evolutional Science and Technology (CREST) program of the Japanese Science and Technology Agency (JST) to A.K. and H.K.

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Author notes

  1. Noriko Takegahara and Hyota Takamatsu: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Molecular Immunology and CREST program of JST, Research Institute for Microbial Diseases, Osaka University, 3–1 Yamada-oka, Suita, Osaka, 565-0871, Japan
    Noriko Takegahara, Hyota Takamatsu, Toshihiko Toyofuku, Masayuki Mizui, Midori Yamamoto, Durbaka V.R. Prasad, Kazuhiro Suzuki, Atsushi Kumanogoh & Hitoshi Kikutani
  2. Department of Internal Medicine and Therapeutics, Graduate School of Medicine, Osaka University, 2–2 Yamada-oka, Suita, Osaka, 565–0871, Japan
    Toshihiko Toyofuku
  3. Department of Pathology, Hyogo College of Medicine, Hyogo, 663–8501, Japan
    Tohru Tsujimura
  4. Department of Neurology, Graduate School of Medicine, Osaka University, 2–2 Yamada-oka, Suita, Osaka, 565–0871, Japan
    Tatsusada Okuno, Masayuki Moriya, Yuji Nakatsuji & Saburo Sakoda
  5. Department of Physiology II, Wakayama Medical College, 811–1 Kimiidera, Wakayama, Wakayama, 641–0012, Japan
    Kazunori Yukawa
  6. Department of Clinical Research, National Osaka Minami Medical Center, Kawachinagano, Osaka, 586–8521, Japan
    Masaru Ishii
  7. Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3–1 Yamada-oka, Suita, Osaka, 565–0871, Japan
    Kenta Terai
  8. Department of Host Defence, Research Institute for Microbial Diseases, Osaka University, and ERATO, Japan Science and Technology Agency, 3–1 Yamada-oka, Suita, Osaka, 565–0871, Japan
    Shintaro Sato & Shizuo Akira
  9. Department of Molecular Genetics, Medical Institute for Bioregulation, Kyushu University, 3–1–1 Maidashi, Higashi-ku, Fukuoka, 812–8582, Japan
    Kiyoshi Takeda
  10. Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Siryo 4–1, Aoba-ku, Sendai 980–8575, Japan and CREST program of JST, Honcho 4–1–8, Kawaguchi, Saitama, 332–0012, Japan
    Masanori Inui & Toshiyuki Takai
  11. Genome Information Research Center, Osaka University, 3–1 Yamada-oka, Suita, Osaka, 565–0871, Japan
    Masahito Ikawa & Masaru Okabe

Authors

  1. Noriko Takegahara
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  2. Hyota Takamatsu
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  3. Toshihiko Toyofuku
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  4. Tohru Tsujimura
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  5. Tatsusada Okuno
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  6. Kazunori Yukawa
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  7. Masayuki Mizui
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  8. Midori Yamamoto
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  9. Durbaka V.R. Prasad
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  10. Kazuhiro Suzuki
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  11. Masaru Ishii
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  12. Kenta Terai
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  13. Masayuki Moriya
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  14. Yuji Nakatsuji
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  15. Saburo Sakoda
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  16. Shintaro Sato
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  17. Shizuo Akira
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  18. Kiyoshi Takeda
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  19. Masanori Inui
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  20. Toshiyuki Takai
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  21. Masahito Ikawa
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  22. Masaru Okabe
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  23. Atsushi Kumanogoh
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  24. Hitoshi Kikutani
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Contributions

N.T. performed the main experimental work and data analysis for bone analysis. H.T. performed the main experimental work and data analysis for the immune responses. T.T., T.T., T.O., K.Y., M.M., M.Y., D.V.R.P., K.S. and S.S. also performed experimental work. M.I. performed calcium signalling analysis. S.A., K.T., M.I. and M.O. were involved in generating knockout mice. M.I. and T.T. performed the DAP12 analysis. A.K. and H.K. co-organized and performed project planning, data analysis, discussion and writing.

Corresponding authors

Correspondence toAtsushi Kumanogoh or Hitoshi Kikutani.

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The authors declare no competing financial interests.

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Takegahara, N., Takamatsu, H., Toyofuku, T. et al. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.Nat Cell Biol 8, 615–622 (2006). https://doi.org/10.1038/ncb1416

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