Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis (original) (raw)
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Acknowledgements
We thank K. Kubota for excellent secretarial assistance. We are grateful to H. Murayama and S. Sato for critical discussion and excellent bone analysis, including microCT and histology. We are also grateful to N. Yamamoto, H. Takayanagi, T. Nakano, I. Ishikawa, H. Arase, N. Yamada, T. Kaisho and K. Hoshino for providing materials, critical advice, discussion and encouragement. We also thank T. Yazawa, A. Kawai, J. Yoshida, K Shiozaki, N. Okita, N. Iwami and K. Nakamura for technical support. This study was supported by research grants from the Ministry of Education, Culture, Sports, Science and Technology, Japan and from the Core Research for Evolutional Science and Technology (CREST) program of the Japanese Science and Technology Agency (JST) to A.K. and H.K.
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Author notes
- Noriko Takegahara and Hyota Takamatsu: These authors contributed equally to this work.
Authors and Affiliations
- Department of Molecular Immunology and CREST program of JST, Research Institute for Microbial Diseases, Osaka University, 3–1 Yamada-oka, Suita, Osaka, 565-0871, Japan
Noriko Takegahara, Hyota Takamatsu, Toshihiko Toyofuku, Masayuki Mizui, Midori Yamamoto, Durbaka V.R. Prasad, Kazuhiro Suzuki, Atsushi Kumanogoh & Hitoshi Kikutani - Department of Internal Medicine and Therapeutics, Graduate School of Medicine, Osaka University, 2–2 Yamada-oka, Suita, Osaka, 565–0871, Japan
Toshihiko Toyofuku - Department of Pathology, Hyogo College of Medicine, Hyogo, 663–8501, Japan
Tohru Tsujimura - Department of Neurology, Graduate School of Medicine, Osaka University, 2–2 Yamada-oka, Suita, Osaka, 565–0871, Japan
Tatsusada Okuno, Masayuki Moriya, Yuji Nakatsuji & Saburo Sakoda - Department of Physiology II, Wakayama Medical College, 811–1 Kimiidera, Wakayama, Wakayama, 641–0012, Japan
Kazunori Yukawa - Department of Clinical Research, National Osaka Minami Medical Center, Kawachinagano, Osaka, 586–8521, Japan
Masaru Ishii - Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3–1 Yamada-oka, Suita, Osaka, 565–0871, Japan
Kenta Terai - Department of Host Defence, Research Institute for Microbial Diseases, Osaka University, and ERATO, Japan Science and Technology Agency, 3–1 Yamada-oka, Suita, Osaka, 565–0871, Japan
Shintaro Sato & Shizuo Akira - Department of Molecular Genetics, Medical Institute for Bioregulation, Kyushu University, 3–1–1 Maidashi, Higashi-ku, Fukuoka, 812–8582, Japan
Kiyoshi Takeda - Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Siryo 4–1, Aoba-ku, Sendai 980–8575, Japan and CREST program of JST, Honcho 4–1–8, Kawaguchi, Saitama, 332–0012, Japan
Masanori Inui & Toshiyuki Takai - Genome Information Research Center, Osaka University, 3–1 Yamada-oka, Suita, Osaka, 565–0871, Japan
Masahito Ikawa & Masaru Okabe
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- Noriko Takegahara
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Contributions
N.T. performed the main experimental work and data analysis for bone analysis. H.T. performed the main experimental work and data analysis for the immune responses. T.T., T.T., T.O., K.Y., M.M., M.Y., D.V.R.P., K.S. and S.S. also performed experimental work. M.I. performed calcium signalling analysis. S.A., K.T., M.I. and M.O. were involved in generating knockout mice. M.I. and T.T. performed the DAP12 analysis. A.K. and H.K. co-organized and performed project planning, data analysis, discussion and writing.
Corresponding authors
Correspondence toAtsushi Kumanogoh or Hitoshi Kikutani.
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Takegahara, N., Takamatsu, H., Toyofuku, T. et al. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.Nat Cell Biol 8, 615–622 (2006). https://doi.org/10.1038/ncb1416
- Received: 21 February 2006
- Accepted: 28 April 2006
- Published: 21 May 2006
- Issue Date: 01 June 2006
- DOI: https://doi.org/10.1038/ncb1416