Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts (original) (raw)

• Dumont, D. J. et al. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes. Dev. 8, 1897–1909 (1994).
  Article CAS PubMed Google Scholar
• Suri, C. et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87, 1171–1180 (1996).
  Article CAS PubMed Google Scholar
• Sato, T. N. et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 367, 70–74 (1995).
  Article Google Scholar
• Yancopoulos, G. D. et al. Vascular-specific growth factors and blood vessel formation. Nature 407, 242–248 (2000).
  Article CAS PubMed Google Scholar
• Peters, K. G. et al. Functional significance of Tie2 signaling in the adult vasculature. Recent Prog. Horm. Res. 59, 51–71 (2004).
  Article CAS PubMed Google Scholar
• Brindle, N. P., Saharinen, P. & Alitalo, K. Signaling and functions of angiopoietin-1 in vascular protection. Circ. Res. 98, 1014–1023 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Eklund, L. & Olsen, B. R. Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. Exp. Cell Res. 312, 630–641 (2006).
  Article CAS PubMed Google Scholar
• Pfaff, D., Fiedler, U. & Augustin, H. Emerging roles of the Angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking. J. Leukocyte Biol. 80, 719–726 (2006).
  Article CAS PubMed Google Scholar
• Wong, A. L. et al. Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circ. Res. 81, 567–574 (1997).
  Article CAS PubMed Google Scholar
• Thurston, G. et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286, 2511–2514 (1999).
  Article CAS PubMed Google Scholar
• Davis, S. et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87, 1161–1169 (1996).
  Article CAS PubMed Google Scholar
• Koblizek, T. I., Weiss, C., Yancopoulos, G. D., Deutsch, U. & Risau, W. Angiopoietin-1 induces sprouting angiogenesis in vitro. Curr. Biol. 8, 529–532 (1998).
  Article CAS PubMed Google Scholar
• Papapetropoulos, A. et al. Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. Lab. Invest. 79, 213–223 (1999).
  CAS PubMed Google Scholar
• Saharinen, P. et al. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J. Cell Biol. 169, 239–243 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Maisonpierre, P.C. et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277, 55–60 (1997).
  Article CAS PubMed Google Scholar
• Teichert-Kuliszewska, K. et al. Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2. Cardiovasc. Res. 49, 659–670 (2001).
  Article CAS PubMed Google Scholar
• Daly, C. et al. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc. Natl Acad. Sci. USA 103, 15491–15496 (2006).
  Article CAS PubMed Google Scholar
• Bogdanovic, E., Nguyen, V. P. & Dumont, D. J. Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization. J. Cell Sci. 119, 3551–3560 (2006).
  Article CAS PubMed Google Scholar
• Cho, C. H. et al. COMP–Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity. Proc. Natl Acad. Sci. USA 101, 5547–5552 (2004).
  Article CAS PubMed Google Scholar
• Cho, C. H. et al. Designed angiopoietin-1 variant, COMP–Ang1, protects against radiation-induced endothelial cell apoptosis. Proc. Natl Acad. Sci. USA 101, 5553–5558 (2004).
  Article CAS PubMed Google Scholar
• Marron, M., Hughes, D. P., Edge, M. D., Forder, C. L. & Brindle, N. Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2. J. Biol. Chem. 275, 39741–39746 (2000).
  Article CAS PubMed Google Scholar
• Yuan, H. T.. et al. Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival. FASEB J. 21, 3171–3178 (2007).
  Article CAS PubMed Google Scholar
• Lampugnani, M. G. et al. The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, β-catenin, and α-catenin with vascular endothelial cadherin (VE–cadherin). J. Cell Biol. 129, 203–217 (1995).
  Article CAS PubMed Google Scholar
• Jones, N. et al. A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function. Mol. Cell. Biol. 23, 2658–2668 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Beardsley, A. et al. Loss of caveolin-1 polarity impedes endothelial cell polarization and directional movement. J. Biol. Chem. 280, 3541–3547 (2005).
  Article CAS PubMed Google Scholar
• Grande-Garcia, A. et al. Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases. J. Cell Biol. 177, 683–694 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Xu, Y. & Yu, Q. Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region. J. Biol. Chem. 276, 34990–34998 (2001).
  Article CAS PubMed Google Scholar
• Fachinger, G., Deutsch, U. & Risau, W. Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene 18, 5948–5953 (1999).
  Article CAS PubMed Google Scholar
• Gamble, J. R. et al. Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circ. Res. 87, 603–607 (2000).
  Article CAS PubMed Google Scholar
• Nawroth, R. et al. VE–PTP and VE–cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J. 21, 4885–4895 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Ridley, A. J. et al. Cell migration: integrating signals from front to back. Science 302, 1704–1709 (2003).
  Article CAS PubMed Google Scholar
• Master, Z. et al. Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak. EMBO J. 20, 5919–5928 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Kim, I. et al. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3´-Kinase/Akt signal transduction pathway. Circ. Res. 86, 24–29 (2000).
  Article CAS PubMed Google Scholar
• Hanahan, D. Signaling vascular morphogenesis and maintenance. Science 277, 48–50 (1997).
  Article CAS PubMed Google Scholar
• Stratmann, A., Risau, W. & Plate, K. H. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. Am. J. Pathol. 153, 1459–1466 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Holash, J. et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284, 1994–1998 (1999).
  Article CAS PubMed Google Scholar
• Edgell, C. J., McDonald, C. C. & Graham, J. B. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl Acad. Sci. USA 80, 3734–3737 (1983).
  Article CAS PubMed Google Scholar
• Lieber, M., Smith, B., Szakal, A., Nelson-Rees, W. & Todaro, G. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int. J. Cancer 17, 62–70 (1976).
  Article CAS PubMed Google Scholar
• Ory, D. S., Neugeboren, B. A. & Mulligan, R. C. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc. Natl Acad. Sci. USA 93, 11400–11406 (1996).
  Article CAS PubMed Google Scholar
• Salven, P. et al. Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis. Br. J. Cancer 74, 69–72 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Andriopoulou, P., Navarro, P., Zanetti, A., Lampugnani, M. G. & Dejana, E. Histamine induces tyrosine phosphorylation of endothelial cell-to-cell adherens junctions. Arterioscler. Thromb. Vasc. Biol. 19, 2286–2297 (1999).
  Article CAS PubMed Google Scholar
• Kim, K. T. et al. Oligomerization and multimerization is critical for angiopoietin-1 to bind and phosphorylate tie2. J. Biol. Chem. 280, 20126–20131 (2005).
  Article CAS PubMed Google Scholar