Germline self-renewal requires cyst stem cells and stat regulates niche adhesion in Drosophila testes (original) (raw)
Tulina, N. & Matunis, E. Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling. Science294, 2546–2549 (2001). ArticleCAS Google Scholar
Kiger, A. A., Jones, D. L., Schulz, C., Rogers, M. B. & Fuller, M. T. Stem cell self-renewal specified by JAK–STAT activation in response to a support cell cue. Science294, 2542–2545 (2001). ArticleCAS Google Scholar
Leatherman, J. L. & Dinardo, S. Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal. Cell Stem Cell3, 44–54 (2008). ArticleCAS Google Scholar
Singh, S. R. et al. Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling. J. Cell Physiol.223, 500–510.
Hardy, R. W., Tokuyasu, K. T., Lindsley, D. L. & Garavito, M. The germinal proliferation center in the testis of Drosophila melanogaster. J. Ultrastruct. Res.69, 180–190 (1979). ArticleCAS Google Scholar
Yamashita, Y. M., Jones, D. L. & Fuller, M. T. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science301, 1547–1550 (2003). ArticleCAS Google Scholar
Yamashita, Y. M., Mahowald, A. P., Perlin, J. R. & Fuller, M. T. Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science315, 518–521 (2007). ArticleCAS Google Scholar
Watt, F. M. & Hogan, B. L. Out of Eden: stem cells and their niches. Science287, 1427–1430 (2000). ArticleCAS Google Scholar
Cheng, J. et al. Centrosome misorientation reduces stem cell division during ageing. Nature456, 599–604 (2008). ArticleCAS Google Scholar
Issigonis, M. et al. JAK–STAT signal inhibition regulates competition in the Drosophila testis stem cell niche. Science326, 153–156 (2009). ArticleCAS Google Scholar
Brawley, C. & Matunis, E. Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivo. Science304, 1331–1334 (2004). ArticleCAS Google Scholar
Shivdasani, A. A. & Ingham, P. W. Regulation of stem cell maintenance and transit amplifying cell proliferation by TGF-β signaling in Drosophila spermatogenesis. Curr. Biol.13, 2065–2072 (2003). ArticleCAS Google Scholar
Kawase, E., Wong, M. D., Ding, B. C. & Xie, T. Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis. Development131, 1365–1375 (2004). ArticleCAS Google Scholar
Schulz, C. et al. A misexpression screen reveals effects of bag-of-marbles and TGF-β Class Signaling on the Drosophila male germine stem cell lineage. Genetics167, 707–723 (2004). ArticleCAS Google Scholar
Wang, L., Li, Z. & Cai, Y. The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche. J. Cell Biol.180, 721–728 (2008). ArticleCAS Google Scholar
Xie, T. & Spradling, A. C. decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell94, 251–260 (1998). ArticleCAS Google Scholar
Chen, D. & McKearin, D. Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells. Curr. Biol.13, 1786–1791 (2003). ArticleCAS Google Scholar
McKearin, D. M. & Spradling, A. C. bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesis. Genes Dev.4, 2242–2251 (1990). ArticleCAS Google Scholar
Decotto, E. & Spradling, A. C. The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals. Dev. Cell9, 501–510 (2005). ArticleCAS Google Scholar
Lopez-Onieva, L., Fernandez-Minan, A. & Gonzalez-Reyes, A. Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary. Development135, 533–540 (2008). ArticleCAS Google Scholar
Deng, W. & Lin, H. Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila. Dev. Biol.189, 79–94 (1997). ArticleCAS Google Scholar
Voog, J., D'Alterio, C. & Jones, D. L. Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis. Nature454, 1132–1136 (2008). ArticleCAS Google Scholar
Flaherty, M. S. et al. chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. Dev. Cell18, 556–568 (2010). ArticleCAS Google Scholar
Yu, K. et al. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development127, 2143–2154 (2000). CASPubMed Google Scholar
Evans, T. A., Haridas, H. & Duffy, J. B. Kekkon5 is an extracellular regulator of BMP signaling. Dev. Biol.326, 36–46 (2009). ArticleCAS Google Scholar
Salic, A. & Mitchison, T. J. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc. Natl Acad. Sci. USA105, 2415–2420 (2008). ArticleCAS Google Scholar
Li, K. & Kaufman, T. C. The homeotic target gene centrosomin encodes an essential centrosomal component. Cell85, 585–596 (1996). ArticleCAS Google Scholar