The quest for myelin in the adult brain (original) (raw)

Nature Cell Biology volume 15, pages 572–575 (2013)Cite this article

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Although myelination largely occurs during early postnatal life, myelinating oligodendrocytes are still generated in the adult brain. Myelin turnover in the adult is necessary for proper neuronal function and is gravely compromised in myelin disorders. The lineage relationship between adult neural stem cells and adult-born oligodendrocytes has been clarified, highlighting molecular pathways that could potentially be targeted to favour de novo myelination in pathological situations.

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Authors and Affiliations

  1. Emanuela Zuccaro and Paola Arlotta are in the Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA,
    Emanuela Zuccaro & Paola Arlotta

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  1. Emanuela Zuccaro
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  2. Paola Arlotta
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Correspondence toPaola Arlotta.

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The authors declare no competing financial interests.

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Zuccaro, E., Arlotta, P. The quest for myelin in the adult brain.Nat Cell Biol 15, 572–575 (2013). https://doi.org/10.1038/ncb2750

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