Phasing in and out (original) (raw)
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- Published: 24 May 2016
Membraneless organelles
Nature Chemistry volume 8, pages 528–530 (2016)Cite this article
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The low-complexity-protein, liquid phases of membraneless organelles have now been established to selectively partition biomolecules. The specialized microenvironment that they provide differs chemically from the surrounding medium and enables specific nucleic-acid remodelling reactions.
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Figure 1: Ddx4N1 liquid droplets selectively partition biomolecules and can alter nucleic acid structure.
References
- Brangwynne, C. P., Tompa, P. & Pappu, R. V. Nature Phys. 11, 899–904 (2015).
Article CAS Google Scholar - Guo, L. & Shorter, J. Mol. Cell 60, 189–192 (2015).
Article CAS Google Scholar - Nott, T. J., Craggs, T. D. & Baldwin, A. J. Nature Chem. 8, 569–575 (2016).
Article CAS Google Scholar - Nott, T. J. et al. Mol. Cell 57, 936–947 (2015).
Article CAS Google Scholar - Thandapani, P., O'Connor, T. R., Bailey, T. L. & Richard, S. Mol. Cell 50, 613–623 (2013).
Article CAS Google Scholar - March, Z. M., King, O. D. & Shorter, J. Brain Res. http://dx.doi.org/10.1016/j.brainres.2016.02.037 (2016).
- Shorter, J. & Taylor, J. P. Rare Dis. 1, e25200 (2013).
Article Google Scholar - Couthouis, J. et al. Hum. Mol. Genet. 21, 2899–2911 (2012).
Article CAS Google Scholar
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- James Shorter is in the Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA,
James Shorter
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- James Shorter
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Correspondence toJames Shorter.
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Shorter, J. Phasing in and out.Nature Chem 8, 528–530 (2016). https://doi.org/10.1038/nchem.2534
- Published: 24 May 2016
- Issue Date: June 2016
- DOI: https://doi.org/10.1038/nchem.2534