Probing cell-division phenotype space and Polo-like kinase function using small molecules (original) (raw)
References
Rajagopalan, H. & Lengauer, C. Aneuploidy and cancer. Nature432, 338–341 (2004). ArticleCAS Google Scholar
Mitchison, T.J. & Salmon, E.D. Mitosis: a history of division. Nat. Cell Biol.3, E17–E21 (2001). ArticleCAS Google Scholar
Inoue, S. & Salmon, E.D. Force generation by microtubule assembly/disassembly in mitosis and related movements. Mol. Biol. Cell6, 1619–1640 (1995). ArticleCAS Google Scholar
Lampson, M.A. & Kapoor, T.M. Unraveling cell division mechanisms with small-molecule inhibitors. Nat. Chem. Biol.2, 19–27 (2006). ArticleCAS Google Scholar
Jordan, M.A. & Wilson, L. Microtubules as a target for anticancer drugs. Nat. Rev. Cancer4, 253–265 (2004). ArticleCAS Google Scholar
Bettencourt-Dias, M. et al. Genome-wide survey of protein kinases required for cell cycle progression. Nature432, 980–987 (2004). ArticleCAS Google Scholar
Kittler, R. & Buchholz, F. Functional genomic analysis of cell division by endoribonuclease-prepared siRNAs. Cell Cycle4, 564–567 (2005). ArticleCAS Google Scholar
Fitzgerald, K. RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. Curr. Opin. Drug Discov. Devel.8, 557–566 (2005). CASPubMed Google Scholar
Specht, K.M. & Shokat, K.M. The emerging power of chemical genetics. Curr. Opin. Cell Biol.14, 155–159 (2002). ArticleCAS Google Scholar
Tan, D.S. Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat. Chem. Biol.1, 74–84 (2005). ArticleCAS Google Scholar
Lipinski, C. & Hopkins, A. Navigating chemical space for biology and medicine. Nature432, 855–861 (2004). ArticleCAS Google Scholar
Evans, B.E. et al. Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. J. Med. Chem.31, 2235–2246 (1988). ArticleCAS Google Scholar
De Corte, B.L. From 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside Inhibitors of HIV-1 reverse transcriptase. J. Med. Chem.48, 1689–1696 (2005). ArticleCAS Google Scholar
Sorbera, L.A., Castaner, J. & Martin, L. Revaprazan hydrochloride: treatment of GERD, H+/K+-ATPase inhibitor, antiulcer drug. Drugs Future29, 455–459 (2004). ArticleCAS Google Scholar
Breault, G.A. et al. Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2,4-bis anilino pyrimidines. Bioorg. Med. Chem. Lett.13, 2961–2966 (2003). ArticleCAS Google Scholar
Legendre, P. & Legendre, L. Numerical ecology (Elsevier, New York, 1998). Google Scholar
Hotha, S. et al. HR22C16: a potent small-molecule probe for the dynamics of cell division. Angew. Chem. Int. Edn. Engl.42, 2379–2382 (2003). ArticleCAS Google Scholar
Aronov, A.M. & Murcko, M.A. Toward a pharmacophore for kinase frequent hitters. J. Med. Chem.47, 5616–5619 (2004). ArticleCAS Google Scholar
Feng, B.Y., Shelat, A., Doman, T.N., Guy, R.K. & Shoichet, B.K. High-throughput assays for promiscuous inhibitors. Nat. Chem. Biol.1, 146–148 (2005). ArticleCAS Google Scholar
Burdine, L. & Kodadek, T. Target identification in chemical genetics: the (often) missing link. Chem. Biol.11, 593–597 (2004). ArticleCAS Google Scholar
Davis-Ward, R., Mook, R.A., Jr., Neeb, M.J. & Salovich, J.M. Preparation of pyrimidine derivatives as Polo-like kinases inhibitors for treatment of cancers (World Patent WO 2004074244, 2004).
Barr, F.A., Sillje, H.H. & Nigg, E.A. Polo-like kinases and the orchestration of cell division. Nat. Rev. Mol. Cell Biol.5, 429–440 (2004). ArticleCAS Google Scholar
Takai, N., Hamanaka, R., Yoshimatsu, J. & Miyakawa, I. Polo-like kinases (Plks) and cancer. Oncogene24, 287–291 (2005). ArticleCAS Google Scholar
Compton, D.A. Spindle assembly in animal cells. Annu. Rev. Biochem.69, 95–114 (2000). ArticleCAS Google Scholar
Sharp, D.J., Rogers, G.C. & Scholey, J.M. Microtubule motors in mitosis. Nature407, 41–47 (2000). ArticleCAS Google Scholar
McInnes, C., Mezna, M. & Fischer, P.M. Progress in the discovery of polo-like kinase inhibitors. Curr. Top. Med. Chem.5, 181–197 (2005). ArticleCAS Google Scholar
Gumireddy, K. et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell7, 275–286 (2005). ArticleCAS Google Scholar
McInnes, C., Meades, C., Mezna, M. & Fischer, P. Benzthiazole-3 oxides useful for the treatment of proliferative disorders (World Patent WO 2004067000, 2004).
van Vugt, M.A. et al. Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis. J. Biol. Chem.279, 36841–36854 (2004). ArticleCAS Google Scholar
Sumara, I. et al. Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr. Biol.14, 1712–1722 (2004). ArticleCAS Google Scholar
Khodjakov, A., Copenagle, L., Gordon, M.B., Compton, D.A. & Kapoor, T.M. Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis. J. Cell Biol.160, 671–683 (2003). ArticleCAS Google Scholar
Toyoshima-Morimoto, F., Taniguchi, E. & Nishida, E. Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep.3, 341–348 (2002). ArticleCAS Google Scholar
Nigg, E.A. Mitotic kinases as regulators of cell division and its checkpoints. Nat. Rev. Mol. Cell Biol.2, 21–32 (2001). ArticleCAS Google Scholar
Hauf, S. et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol.161, 281–294 (2003). ArticleCAS Google Scholar
Niiya, F., Xie, X., Lee, K.S., Inoue, H. & Miki, T. Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner. J. Biol. Chem.280, 36502–36509 (2005). ArticleCAS Google Scholar
Lampson, M.A., Renduchitala, K., Khodjakov, A. & Kapoor, T.M. Correcting improper chromosome-spindle attachments during cell division. Nat. Cell Biol.6, 232–237 (2004). ArticleCAS Google Scholar
Dogterom, M., Kerssemakers, J.W., Romet-Lemonne, G. & Janson, M.E. Force generation by dynamic microtubules. Curr. Opin. Cell Biol.17, 67–74 (2005). ArticleCAS Google Scholar
Li, X. & Nicklas, R.B. Mitotic forces control a cell-cycle checkpoint. Nature373, 630–632 (1995). ArticleCAS Google Scholar
Waters, J.C., Mitchison, T.J., Rieder, C.L. & Salmon, E.D. The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work. Mol. Biol. Cell7, 1547–1558 (1996). ArticleCAS Google Scholar
Gergely, F., Draviam, V.M. & Raff, J.W. The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes Dev.17, 336–341 (2003). ArticleCAS Google Scholar
Joseph, J., Liu, S.T., Jablonski, S.A., Yen, T.J. & Dasso, M. The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo. Curr. Biol.14, 611–617 (2004). ArticleCAS Google Scholar
Garrett, S., Auer, K., Compton, D.A. & Kapoor, T.M. hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division. Curr. Biol.12, 2055–2059 (2002). ArticleCAS Google Scholar
Gruber, J., Harborth, J., Schnabel, J., Weber, K. & Hatzfeld, M. The mitotic-spindle-associated protein astrin is essential for progression through mitosis. J. Cell Sci.115, 4053–4059 (2002). ArticleCAS Google Scholar
Adams, R.R., Maiato, H., Earnshaw, W.C. & Carmena, M. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J. Cell Biol.153, 865–880 (2001). ArticleCAS Google Scholar
Holt, S.V. et al. Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint. J. Cell Sci.118, 4889–4900 (2005). ArticleCAS Google Scholar
Zhu, C. et al. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol. Biol. Cell16, 3187–3199 (2005). ArticleCAS Google Scholar
Dai, J., Sultan, S., Taylor, S.S. & Higgins, J.M. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes Dev.19, 472–488 (2005). ArticleCAS Google Scholar
McEwen, B.F., Heagle, A.B., Cassels, G.O., Buttle, K.F. & Rieder, C.L. Kinetochore fiber maturation in PtK1 cells and its implications for the mechanisms of chromosome congression and anaphase onset. J. Cell Biol.137, 1567–1580 (1997). ArticleCAS Google Scholar
Knight, Z.A. & Shokat, K.M. Features of selective kinase inhibitors. Chem. Biol.12, 621–637 (2005). ArticleCAS Google Scholar
Tanaka, M. et al. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol.3, e128 (2005). Article Google Scholar
Qian, Y.W., Erikson, E., Li, C. & Maller, J.L. Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis. Mol. Cell. Biol.18, 4262–4271 (1998). ArticleCAS Google Scholar