Is there a link between diet and esophageal cancer? (original) (raw)

Nature Clinical Practice Gastroenterology & Hepatology volume 4, pages 2–3 (2007)Cite this article

Esophageal cancer is the sixth leading cause of cancer-related death worldwide. The overall incidence and associated mortality of esophageal cancer in the US has increased by 15–20% over the past 3 decades.1,2 By contrast, in the European Union, esophageal cancer mortality reached a plateau and has subsequently been declining in men since the late 1980s.3 The main esophageal cancer subtypes are squamous-cell carcinoma and adenocarcinoma.2 Over the last 30 years, the incidence of squamous-cell carcinoma has decreased in several areas of the world, but adenocarcinoma has risen by over fourfold in the US as well as in Australia and several areas of Europe; its incidence has particularly increased in men.1,2,3 In the US, the squamous-cell carcinoma to adenocarcinoma incidence ratio has decreased from 3:1 in 1975 to 2:1 in 1988, and to 1.2:1 in 1994. Currently, there are more new cases of adenocarcinoma than of squamous-cell carcinoma.2

The widespread unfavorable trends for the development of esophageal adenocarcinoma have been related to a number of risk factors, which are (at least in part) different from those of esophageal squamous-cell carcinoma.2 Tobacco use and alcohol consumption are the dominant risk factors for squamous-cell carcinoma,1 while the dominant risk factors for adenocarcinoma are mainly related to tobacco smoking and gastroesophageal reflux, but unrelated to alcohol drinking.1,2 BMI seems to be inversely associated with the risk of squamous-cell carcinoma,2 whereas overweight and obesity have been directly linked to adenocarcinoma.1,2

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References

  1. Engel LS et al. (2003) Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst 95: 1404–1413
    Article Google Scholar
  2. Levi F et al. (2001) Epidemiology of adenocarcinoma and squamous cell carcinoma of the oesophagus. Eur J Cancer Prev 10: 91–96
    Article CAS Google Scholar
  3. Levi F et al. (2004) Cancer mortality in Europe, 1995–1999, and an overview of trends since 1960. Int J Cancer 110: 155–169
    Article CAS Google Scholar
  4. World Cancer Research Fund (WCRF) (1997) Food, nutrition and the prevention of cancer: a global perspective. Washington: American Institute for Cancer Research
  5. Bosetti C et al. (2000) Food groups and risk of squamous cell esophageal cancer in northern Italy. Int J Cancer 87: 289–294
    Article CAS Google Scholar
  6. De Stefani E et al. (2003) Food groups and risk of squamous cell carcinoma of the oesophagus: a case–control study in Uruguay. Br J Cancer 89: 1209–1214
    Article CAS Google Scholar
  7. Gallus S et al. (2004) Mediterranean diet and cancer risk. Eur J Cancer Prev 13: 447–452
    Article CAS Google Scholar
  8. Galeone C et al. (2005) Role of fried foods and oral/pharyngeal and oesophageal cancers. Br J Cancer 92: 2065–2069
    Article CAS Google Scholar
  9. Mayne ST et al. (2006) Carbonated soft drink consumption and risk of esophageal adenocarcinoma. J Natl Cancer Inst 98: 72–75
    Article Google Scholar
  10. La Vecchia C et al. (2002) Oesophageal adenocarcinoma: a paradigm of mechanical carcinogenesis? Int J Cancer 102: 269–270
    Article CAS Google Scholar

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Authors and Affiliations

  1. S Gallus is the Chief of the Unit of Epidemiology for Clinical Research in the Laboratory of Epidemiology at the Istituto di Ricerche Farmacologiche Mario Negri. C La Vecchia is the Chief of the Laboratory of Epidemiology at the Istituto di Ricerche Farmacologiche Mario Negri, and an Associate Professor of Epidemiology at the Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy.,
    Silvano Gallus & Carlo La Vecchia

Authors

  1. Silvano Gallus
  2. Carlo La Vecchia

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Correspondence toSilvano Gallus.

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The authors declare no competing financial interests.

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Gallus, S., La Vecchia, C. Is there a link between diet and esophageal cancer?.Nat Rev Gastroenterol Hepatol 4, 2–3 (2007). https://doi.org/10.1038/ncpgasthep0697

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