Common variants near MC4R are associated with fat mass, weight and risk of obesity (original) (raw)
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Acknowledgements
We acknowledge support of the UK Medical Research Council, the Wellcome Trust, Diabetes UK, Cancer Research United Kingdom, BDA Research, UK National Health Service Research and Development, the European Commission, the Academy of Finland, the British Heart Foundation, the National Institutes of Health, the Novartis Institutes for BioMedical Research, GlaxoSmithKline and the German National Genome Research Net. Personal support was provided by NIDDK (E.K.S., H.N.L., J.N.H., F.S.C.), the Wellcome Trust (A.T.H., E.Z.), Diabetes UK (R.M.F.), the Throne-Holst Foundation (C.M.L.), the Vandervell Foundation (M.N.W.), American Diabetes Association (C.J.W.), Unilever Corporate Research (S.L.) and the British Heart foundation (N.J.S).
Author information
Author notes
- Ruth J F Loos, Cecilia M Lindgren, Shengxu Li, Mark I McCarthy, Nicholas J Wareham and Inês Barroso: These authors contributed equally to this work.
- Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.
Authors and Affiliations
- MRC Epidemiology Unit, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK
Ruth J F Loos, Shengxu Li, Jing Hua Zhao, Ken K Ong, Manjinder S Sandhu, Matthew A Sims & Nicholas J Wareham - Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK
Ruth J F Loos, Shengxu Li, Jing Hua Zhao, I Sadaf Farooqi, Ken K Ong, Stephen O'Rahilly, Matthew A Sims, Vicki L Wraight & Nicholas J Wareham - Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
Cecilia M Lindgren, Inga Prokopenko, Amanda J Bennett, Katherine S Elliott, David M Evans, Christopher J Groves, Blanca Herrera, Joshua C Randall, Nigel W Rayner, Nicholas J Timpson, Eleftheria Zeggini & Mark I McCarthy - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
Cecilia M Lindgren, Inga Prokopenko, Amanda J Bennett, Christopher J Groves, Blanca Herrera, Fredrik Karpe, Matthew J Neville, Katharine R Owen, Joshua C Randall, Nigel W Rayner & Mark I McCarthy - Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
Eleanor Wheeler, Michael Inouye, Antony P Attwood, Emmanouil T Dermitzakis, Jilur Ghori, Rhian Gwilliam, Sarah E Hunt, Andrew Keniry, Ralph McGinnis, Alexandra C Nica, Simon Potter, Nicole Soranzo, Panos Deloukas & Inês Barroso - Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, EX1 2LU, UK
Rachel M Freathy, Andrew T Hattersley, Michael N Weedon & Timothy M Frayling - Diabetes Genetics, Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter, EX2 5DW, UK
Rachel M Freathy, Andrew T Hattersley, Michael N Weedon & Timothy M Frayling - Department of Haematology, University of Cambridge, and NHS (National Health Service) Blood and Transplant, Cambridge Centre, Long Road, Cambridge, UK
Antony P Attwood, Jennifer D M Jolley & Willem H Ouwehand - Department of Medical Genetics, University of Lausanne, 1011, Switzerland
Jacques S Beckmann, Sven Bergmann & Toby Johnson - Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, 1011, Switzerland
Jacques S Beckmann - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services (DHHS), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Sonja I Berndt, Stephen J Chanock & Richard B Hayes - Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland
Sven Bergmann & Toby Johnson - MRC Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Cambridge, CB2 0XY, UK
Sheila A Bingham - University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, 1011, Switzerland
Murielle Bochud & Toby Johnson - Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
Morris Brown - CNRS-8090-Institute of Biology, Pasteur Institute, Lille, 5900, France
Stéphane Cauchi, Christian Dina, Philippe Froguel & David Meyre - BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, UK
John M Connell - MRC Epidemiology Resource Centre, University of Southampton, Southampton, SO16 6YD, UK
Cyrus Cooper, Ian Day & Holly E Syddall - The MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, BS8 2PR, UK
George Davey Smith, David M Evans & Nicholas J Timpson - MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK
Subhajyoti De & Sarah A Teichmann - Division of Medicine and Therapeutics, Diabetes Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK
Alex S F Doney & Andrew D Morris - Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK
Paul Elliott & Marjo-Riitta Jarvelin - Department of Public Health Science and General Practice, Fin-90014, University of Oulu, Finland
Paul Elliott & Marjo-Riitta Jarvelin - Metabolic Research Laboratories, University of Cambridge, Cambridge, CB2 0QQ, UK
I Sadaf Farooqi, Stephen O'Rahilly & Vicki L Wraight - Genomic Medicine, Hammersmith Hospital, Imperial College London, London, W12 ONN, UK
Philippe Froguel - Division of Community Health Sciences, St George's, University of London, London, SW17 0RE, UK
David Hadley, Konstantinos Papadakis & David P Strachan - LIGHT Research Institutes, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, UK
Alistair S Hall - Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, D45147, Germany
Johannes Hebebrand, Anke Hinney & Carla I Ganz Vogel - GSF-Institute of Epidemiology, Neuherberg-Munich, D-85764, Germany
Iris M Heid, Claudia Lamina, Christian Gieger, Thomas Illig & H-Erich Wichmann - IBE Chair of Epidemiology, University of Munich, Munich, D-81377, Germany
Iris M Heid, Christian Gieger & H-Erich Wichmann - Department of Child and Adolescent Health, National Public Health Institute, Oulu, 90221, Finland
Marjo-Riitta Jarvelin & Anneli Pouta - Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, CB2 2SR, UK
Kay-Tee Khaw, Robert N Luben & Manjinder S Sandhu - Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
Massimo Mangino & Nilesh J Samani - Department of Statistics, University of Oxford, 1 South Parks Road, Oxford, OX1 3TG, UK
Jonathan Marchini - Department of Social Medicine, University of Bristol,
Wendy L McArdle & Susan M Ring - Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
Wendy L McArdle & Susan M Ring - Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine, Charterhouse Square, London, EC1M 6BQ, UK
Patricia B Munroe, Chris Wallace & Mark J Caulfield - Department of Oral and Dental Science, Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, UK
Andrew R Ness - Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK
Colin N A Palmer - Department of Obstetrics and Gynaecology, University Hospital of Oulu, P.P. Box 22, Oulu, 90221, Finland
Anneli Pouta - Department of Nutrition, Harvard School of Public Health, Boston, 02115, Massachusetts, USA
Lu Qi, David J Hunter & Frank B Hu - Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, 45122, Germany
André Scherag - Medical Genetics/Clinical Pharmacology and Discovery Medicine, King of Prussia, 19406, Pennsylvania, USA
Kijoung Song, Dawn M Waterworth, Xin Yuan & Vincent Mooser - Department of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, Massachusetts, USA
Elizabeth K Speliotes - Broad Institute at MIT and Harvard, Boston, 02115, Massachusetts, USA
David J Hunter, Elizabeth K Speliotes, Helen N Lyon, Benjamin F Voight & Joel N Hirschhorn - Clinical Science at South Bristol, University of Bristol, Bristol, BS2 8AE, UK
Jonathan H Tobias - Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, 09100, Italy
Manuela Uda, Serena Sanna & Giuseppe Albai - Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, Michigan, USA
Cristen J Willer, Anne U Jackson & Michael Boehnke - Department of Genetics, Harvard Medical School, Boston, 02115, Massachusetts, USA
Helen N Lyon & Joel N Hirschhorn - Division of Genetics, Children's Hospital, Boston, 02115, Massachusetts, USA
Joel N Hirschhorn - Department of Pediatrics, Harvard Medical School, Boston, 02115, Massachusetts, USA
Helen N Lyon & Joel N Hirschhorn - Division of Endocrinology, Children's Hospital, Boston, 02115, Massachusetts, USA
Joel N Hirschhorn - Department of Medicine and Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, 1011, Switzerland
Peter Vollenweider & Gerard Waeber - Bioinformed Consulting Services, Gaithersburg, 20877, Maryland, USA
Kevin B Jacobs - Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, DHHS, Bethesda, 20892, Maryland, USA
Stephen J Chanock - GSF-Institute of Human Genetics, Neuherberg-Munich, D-85764, Germany
Thomas Meitinger - Institute of Human Genetics, Technical University Munich, Munich, D-81671, Germany
Thomas Meitinger - Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, 02115, Massachusetts, USA
Peter Kraft & David J Hunter - Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Boston, 02115, Massachusetts, USA
Susan E Hankinson, David J Hunter & Frank B Hu - Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA
Benjamin F Voight - Department of Medicine, Massachusetts General Hospital and Harvard Medical School Boston, 02114, Massachusetts, USA
Benjamin F Voight - Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA
Benjamin F Voight - Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, S-205 02, Sweden
Martin Ridderstrale & Leif Groop - Department of Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, 00029, Finland
Leif Groop - Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, Michigan, USA
Paul Scheet & Goncalo R Abecasis - Gerontology Research Center, National Institute on Aging, Baltimore, 21244, Maryland, USA
Ramaiah Nagaraja & David Schlessinger - Department of Epidemiology and Health Promotion, Diabetes Unit, National Public Health Institute, Helsinki, 00300, Finland
Jaakko Tuomilehto & Jaakko Tuomilehto - South Ostrobothnia Central Hospital, Seinäjoki, 60220, Finland
Jaakko Tuomilehto - Genome Technology Branch, National Human Genome Research Institute, Bethesda, 20892, Maryland, USA
Francis S Collins - Department of Genetics, University of North Carolina, Chapel Hill, 27599, North Carolina, USA
Karen L Mohlke
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Consortia
The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
- Kevin B Jacobs
- , Stephen J Chanock
- & Richard B Hayes
KORA
- Claudia Lamina
- , Christian Gieger
- , Thomas Illig
- , Thomas Meitinger
- & H-Erich Wichmann
Nurses' Health Study
- Peter Kraft
- , Susan E Hankinson
- , David J Hunter
- & Frank B Hu
Diabetes Genetics Initiative
- Helen N Lyon
- , Benjamin F Voight
- , Martin Ridderstrale
- & Leif Groop
The SardiNIA Study
- Paul Scheet
- , Serena Sanna
- , Goncalo R Abecasis
- , Giuseppe Albai
- , Ramaiah Nagaraja
- & David Schlessinger
The Wellcome Trust Case Control Consortium
FUSION
- Anne U Jackson
- , Jaakko Tuomilehto
- , Francis S Collins
- , Michael Boehnke
- & Karen L Mohlke
Contributions
Writing team: R.J.F.L., C.M.L., S.L., M.I.M., N.J.W., I.B.
Project management: R.J.F.L., C.M.L., P.D., M.I.M., N.J.W., I.B.
Genome-wide association sampling, genotyping and analysis: R.J.F.L., C.M.L., S.L., E.W., J.H.Z., I.P., M.I., A.P.A., J.S.B., S.B., S.A.B., M. Bochud, M. Brown, J.M.C., D.M.E., J.G., R.G., D.H., A.S.H., A.T.H., S.E.H., T.J., J.D.M.J., A.K., K.-T.K., R.L., M.M., J.M., W.L.M., R.M., P.B.M., A.C.N., K.K.O., K.P., S.P., S.M.R., M.S.S., M.A.S., K.S., N.S., N.J.T., C.W., D.M.W., M.N.W., The Wellcome Trust Case Control Consortium, X.Y., E.Z., D.P.S., W.H.O., M.J.C., N.J.S., T.M.F., P.V., G.W., V.M., P.D., M.I.M., N.J.W., I.B., A.J.B.
Replication samples, genotyping and analysis in adults: R.J.F.L., C.M.L., S.L., R.M.F., A.P.A., A.B., S.C., C.C., G.D.S., I.D., C.D., A.S.F.D., P.E., D.M.E., P.F., C.J.G., A.T.H., M.-R.J., J.D.M.J., F.K., D.M., A.D.M., M.J.N., K.K.O., S.O., K.R.O., C.N.A.P., A.P., A.R.N., S.M.R., M.S.S., M.A.S., H.E.S., N.J.T., M.N.W., V.L.W., E.Z., W.H.O., T.M.F., M.I.M., N.J.W., I.B.
GIANT Consortium samples, genotyping and analysis: S.I.B., K.B.J., S.J.C., R.B.H., I.M.H., C.L., C.G., T.I., T.M., H.-E.W., L.Q., P K., S.E.H., D.J.H., F.B.H, E.K.S., H.N.L., B.F.V., M.R., L.G., J.N.H., M.U., P.S., S.S., G.R.A., G.A., R.N., D.S., C.J.W., A.U. J., J.T., F.S.C., M. Boehnke., K.L.M., FUSION, DGI, PLCO, NHS, SardiNIA.
Replication samples, analysis and genotyping in children: R.M.F., S.C., G.D.S., I.D., C.D., I.S.F., P.F., A.T.H., J.H., A.H., D.M., A.R.N., K.K.O., S.O., S.M.R., A.S., N.J.T., J.H.T., V.L.W., T.M.F., C.I.G.V.
Statistical analysis and informatics: R.J.F.L., C.M.L., S.L., J.H.Z., I.P., R.M.F., S.D., E.T.D., K.S.E., B.H., S.E.H., T.J., J.M., R.M., S.P., J.C.R., N.W.R., A.S., S.A.T., N.J.T., E.Z., M.I.M., N.J.W., I.B.
Corresponding authors
Correspondence toMark I McCarthy, Nicholas J Wareham or Inês Barroso.
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Competing interests
Vincent Mooser, Dawn Waterworth and Kijoung Song are full-time employees of GlaxoSmithKline.
Peter Vollenweider and Gérard Waeber received financial support from GlaxoSmithKline to build the CoLaus study.
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Loos, R., Lindgren, C., Li, S. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity.Nat Genet 40, 768–775 (2008). https://doi.org/10.1038/ng.140
- Received: 16 November 2007
- Accepted: 19 February 2008
- Published: 04 May 2008
- Issue Date: June 2008
- DOI: https://doi.org/10.1038/ng.140