Exome sequencing of liver fluke–associated cholangiocarcinoma (original) (raw)

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References

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Acknowledgements

We thank L. Farber for editing the manuscript. This work is supported in part by funding from the Singapore National Medical Research Council (NMRC/STAR/0006/2009), The Singapore Millennium Foundation, The Lee Foundation, the Singapore National Cancer Centre Research Fund, the Duke-NUS Graduate Medical School, the Cancer Science Institute, Singapore, the Research Team Strengthening Grant, the National Genetic Engineering and Biotechnology Center and the National Science and Technology Development Agency, Thailand. W.Y. is the recipient of the NUS Graduate School for Integrative Sciences and Engineering Scholarship, Singapore.

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Author notes

1. Choon Kiat Ong and Chutima Subimerb: These authors contributed equally to this work.

Authors and Affiliations

1. Division of Medical Sciences, National Cancer Centre Singapore–Van Andel Research Institute Translational Research Laboratory, National Cancer Centre, Singapore
   Choon Kiat Ong, Chutima Subimerb, Willie Yu, George E Allen, Cedric Chuan Young Ng, Bernice Huimin Wong, Swe Swe Myint, Vikneswari Rajasegaran, Hong Lee Heng, Anna Gan, DaChuan Huang, Pauline Ong, Waraporn Chan-on & Bin Tean Teh
2. Division of Cancer and Stem Cell Biology, Duke–National University of Singapore (NUS) Graduate Medical School, Singapore
   Choon Kiat Ong, Chutima Subimerb, Willie Yu, George E Allen, Cedric Chuan Young Ng, Bernice Huimin Wong, Swe Swe Myint, Vikneswari Rajasegaran, Hong Lee Heng, Anna Gan, Zhi Jiang Zang, Jeanie Wu, Ming Hui Lee, DaChuan Huang, Pauline Ong, Waraporn Chan-on, Patrick Tan & Bin Tean Teh
3. Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
   Chutima Subimerb, Chawalit Pairojkul, Sopit Wongkham, Waraporn Chan-on, Veerapol Kukongviriyapan, Banchob Sripa, Chaisiri Wongkham, Puangrat Yongvanit & Vajarabhongsa Bhudhisawasdi
4. Division of Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore
   Ioana Cutcutache, John R McPherson, Yingting Wu & Steve Rozen
5. NUS Graduate School for Integrative Sciences and Engineering, Singapore
   Willie Yu
6. Division of Cellular and Molecular Research, National Cancer Centre, Singapore
   Zhi Jiang Zang
7. Computation and Systems Biology, Singapore-MIT Alliance, Singapore
   Yingting Wu
8. Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China
   Yun Cao & Chao-Nan Qian
9. Department of Pathology, Singapore General Hospital, Singapore
   Kiat Hon Lim
10. Laboratory of Computational Biology, Van Andel Research Institute, Grand Rapids, Michigan, USA
    Aikseng Ooi, Karl Dykema & Kyle Furge
11. Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK
    P Andrew Futreal
12. Cancer Science Institute of Singapore, NUS, Singapore
    Patrick Tan
13. Genome Institute of Singapore, Singapore
    Patrick Tan

Authors

1. Choon Kiat Ong
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2. Chutima Subimerb
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3. Chawalit Pairojkul
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4. Sopit Wongkham
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5. Ioana Cutcutache
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6. Willie Yu
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7. John R McPherson
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8. George E Allen
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9. Cedric Chuan Young Ng
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10. Bernice Huimin Wong
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11. Swe Swe Myint
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12. Vikneswari Rajasegaran
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13. Hong Lee Heng
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14. Anna Gan
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15. Zhi Jiang Zang
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16. Yingting Wu
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17. Jeanie Wu
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18. Ming Hui Lee
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19. DaChuan Huang
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20. Pauline Ong
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21. Waraporn Chan-on
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22. Yun Cao
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23. Chao-Nan Qian
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24. Kiat Hon Lim
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25. Aikseng Ooi
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26. Karl Dykema
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27. Kyle Furge
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28. Veerapol Kukongviriyapan
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29. Banchob Sripa
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30. Chaisiri Wongkham
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31. Puangrat Yongvanit
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32. P Andrew Futreal
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33. Vajarabhongsa Bhudhisawasdi
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34. Steve Rozen
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35. Patrick Tan
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36. Bin Tean Teh
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Contributions

C.K.O., C.S., C.P., S.W., V.B., S.R., P.T. and B.T.T. conceived the study. V.B., S.R., P.T. and B.T.T. directed the study. C.P., S.W., Y.C., C.-N.Q., K.H.L., V.K., B.S., C.W., P.Y. and V.B. involved in procurement and histopathological review of samples. I.C., W.Y., J.R.M., G.E.A., Y.W., A.O., K.D., K.F., P.A.F. and S.R. performed the bioinformatics data analysis. C.K.O., C.S., C.C.Y.N., B.H.W., S.S.M., V.R., H.L.H., A.G., Z.J.Z., J.W., M.H.L., D.H., P.O. and W.C. performed the experiment on sequencing and the SNP array study. C.K.O. and B.T.T. wrote the manuscript, with the assistance and final approval of all authors.

Corresponding authors

Correspondence toVajarabhongsa Bhudhisawasdi, Steve Rozen, Patrick Tan or Bin Tean Teh.

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Competing interests

The authors declare no competing financial interests.

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Ong, C., Subimerb, C., Pairojkul, C. et al. Exome sequencing of liver fluke–associated cholangiocarcinoma.Nat Genet 44, 690–693 (2012). https://doi.org/10.1038/ng.2273

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• Received: 23 September 2011
• Accepted: 11 April 2012
• Published: 06 May 2012
• Issue Date: June 2012
• DOI: https://doi.org/10.1038/ng.2273