A tumor-specific stem cell (original) (raw)

Nature Genetics volume 45, pages 7–9 (2013)Cite this article

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Cancer stem cells are thought to share many characteristics with their normal stem cell counterparts, raising concerns about the ability to selectively target them. A new study shows that Dclk1 marks cancer, but not normal, stem cells in the intestine and that targeting this population results in adenoma collapse without affecting normal tissue.

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Figure 1: Intestinal CSCs are distinct from NSCs.

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Authors and Affiliations

  1. Ciara Metcalfe and Frederic J. de Sauvage are in the Department of Molecular Biology at Genentech, Inc., South San Francisco, California, USA.,
    Ciara Metcalfe & Frederic J de Sauvage

Authors

  1. Ciara Metcalfe
  2. Frederic J de Sauvage

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Correspondence toFrederic J de Sauvage.

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Competing interests

The authors are employees of Genentech, Inc., and F.J.d.S. owns shares of Roche.

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Metcalfe, C., de Sauvage, F. A tumor-specific stem cell.Nat Genet 45, 7–9 (2013). https://doi.org/10.1038/ng.2502

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