Frequent truncating mutations of STAG2 in bladder cancer (original) (raw)

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References

1. Solomon, D.A. et al. Science 333, 1039–1043 (2011).
   Article CAS Google Scholar
2. Walter, M.J. et al. N. Engl. J. Med. 366, 1090–1098 (2012).
   Article CAS Google Scholar
3. Cancer Genome Atlas Research Network. Nature 474, 609–615 (2011).
4. Howlader, N. et al. SEER Cancer Statistics Review, 1975–2009 (Vintage 2009 Populations), http://seer.cancer.gov/csr/1975_2009_pops09/, based on November 2011 SEER data submission.
5. Welch, J.S. et al. Cell 150, 264–278 (2012).
   Article CAS Google Scholar
6. Michaelis, C., Ciosk, R. & Nasmyth, K. Cell 91, 35–45 (1997).
   Article CAS Google Scholar
7. Rao, H. et al. Nature 410, 955–959 (2001).
   Article CAS Google Scholar
8. Remeseiro, S. et al. EMBO J. 31, 2076–2089 (2012).
   Article CAS Google Scholar
9. Miettinen, M. Appl. Immunohistochem. 20, 410–412 (2012).
   Article Google Scholar
10. Miettinen, M. et al. Am. J. Surg. Pathol. 36, 629–639 (2012).
    Article Google Scholar
11. Kim, J.H. et al. Lab. Invest. 85, 532–549 (2005).
    Article CAS Google Scholar
12. Rink, M. et al. Urol. Oncol. doi:10.1016/j.urolonc.2012.06.011 (1 September 2012).
13. Solomon, D.A. et al. Cancer Res. 68, 10300–10306 (2008).
    Article CAS Google Scholar

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Acknowledgements

We thank B. Vogelstein for assistance in acquiring samples and preparing genomic DNA. This work was supported by US National Institutes of Health grants R01CA169345, R01CA159467 and R21CA143282 to T.W., by the MD Anderson Cancer Center Bladder Cancer SPORE grant P50CA091846 and by the Intramural Research Program of the National Human Genome Research Institute, US National Institutes of Health.

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Author notes

1. Shahrokh F Shariat
   Present address: Present address: Department of Urology, Medical University of Vienna, Vienna, Austria.,

Authors and Affiliations

1. Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC, USA
   David A Solomon, Jung-Sik Kim, Julia Gerard & Todd Waldman
2. Department of Pathology, University of California, San Francisco, San Francisco, California, USA
   David A Solomon & Joanna J Phillips
3. Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
   Jolanta Bondaruk, Shizhen Zhang & Bogdan Czerniak
4. Department of Urology, Weill Cornell College of Medicine, New York, New York, USA
   Shahrokh F Shariat, DaZhong Zhuang, Brian D Robinson & Mark A Rubin
5. Division of Medical Oncology, Weill Cornell College of Medicine, New York, New York, USA
   Shahrokh F Shariat
6. Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA
   Zeng-Feng Wang & Markku Miettinen
7. Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
   Abdel G Elkahloun
8. Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
   Tomoko Ozawa & C David James
9. Department of Urology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
   Neema Navai
10. Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Arlene Siefker-Radtke
11. Department of Pathology, Weill Cornell College of Medicine, New York, New York, USA
    Brian D Robinson & Mark A Rubin
12. Department of Urology, Hospital Kassel, Kassel, Germany
    Björn Volkmer
13. Department of Urology, University Hospital Ulm, Ulm, Germany
    Richard Hautmann
14. Department of Urology, Hospital Am Eichert, Göppingen, Germany
    Rainer Küfer
15. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Pancras C W Hogendoorn
16. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    George Netto
17. Department of Surgery, University of Colorado Cancer Center, University of Colorado School of Medicine, Aurora, Colorado, USA
    Dan Theodorescu

Authors

1. David A Solomon
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2. Jung-Sik Kim
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3. Jolanta Bondaruk
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4. Shahrokh F Shariat
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5. Zeng-Feng Wang
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6. Abdel G Elkahloun
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7. Tomoko Ozawa
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8. Julia Gerard
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9. DaZhong Zhuang
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10. Shizhen Zhang
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11. Neema Navai
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12. Arlene Siefker-Radtke
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13. Joanna J Phillips
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14. Brian D Robinson
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15. Mark A Rubin
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16. Björn Volkmer
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17. Richard Hautmann
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18. Rainer Küfer
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19. Pancras C W Hogendoorn
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20. George Netto
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21. Dan Theodorescu
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22. C David James
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23. Bogdan Czerniak
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24. Markku Miettinen
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25. Todd Waldman
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Contributions

D.A.S., J.-S.K., J.B., S.F.S., C.D.J., B.C., M.M. and T.W. designed research. D.A.S., J.-S.K., J.B., Z.-F.W., A.G.E., T.O., J.G., D.Z., S.Z. and J.J.P. performed research. J.B., S.F.S., D.Z., M.A.R., B.V., R.H., R.K., P.C.W.H., G.N., D.T., B.C. and M.M. contributed new reagents and analytic tools. D.A.S., J.-S.K., S.F.S., A.G.E., N.N., A.S.-R., B.D.R., C.D.J., M.M. and T.W. analyzed data. D.A.S., S.F.S. and T.W. wrote the manuscript.

Corresponding author

Correspondence toTodd Waldman.

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Competing interests

A provisional patent application has been filed by Georgetown University related to the technology described in this paper on which D.A.S., J.-S.K. and T.W. are the inventors.

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Solomon, D., Kim, JS., Bondaruk, J. et al. Frequent truncating mutations of STAG2 in bladder cancer.Nat Genet 45, 1428–1430 (2013). https://doi.org/10.1038/ng.2800

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• Received: 19 March 2013
• Accepted: 18 September 2013
• Published: 13 October 2013
• Issue Date: December 2013
• DOI: https://doi.org/10.1038/ng.2800