Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse (original) (raw)

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Acknowledgements

We thank the patients and parents who participated in the COG protocols included in this study, the clinicians and research staff at COG institutions and J. Pullen (University of Mississippi at Jackson) for assistance in the classification of patients with ALL. Genome-wide genotyping of COG P9905 samples was performed by the Center for Molecular Medicine with generous financial support from the Jeffrey Pride Foundation and the National Childhood Cancer Foundation. V.P.-A. is supported by a Spanish Ministry of Education Fellowship Grant and by a St. Jude Children's Research Hospital Academic Programs Special Fellowship. J.J.Y. is supported by an American Society of Hematology Scholar Award, an Alex Lemonade Stand Foundation for Childhood Cancer Young Investigator Grant and by the Order of St. Francis Foundation. K.G.R. is supported by a National Health and Medical Research Council (Australia) Overseas Training Fellowship and by a Haematology Society of Australia and New Zealand Novartis New Investigator Scholarship. C.G.M. is a Pew Scholar in the Biomedical Sciences and a St. Baldrick's Scholar. We thank M. Shriver (Pennsylvania State University) for sharing SNP genotype data for the Native American references, J. Pritchard and J. Degner (University of Chicago) for sharing DNase I hypersensitivity data for HapMap YRI cell lines, R.C. Ribeiro (St. Jude Children's Research Hospital) and P. De Alarcon (University of Illinois College of Medicine at Peoria) for coordinating collaborations in Guatemala and S. Naron for her editorial assistance. This work was supported by the US National Institutes of Health (grant numbers CA156449, CA21765, CA36401, CA98543, CA114766, CA98413, CA140729 and GM92666), in part by the intramural Program of the National Cancer Institute and by the American Lebanese Syrian Associated Charities (ALSAC). Study sponsors were not directly involved in the design of the study, the collection, analysis and interpretation of data, the writing of the manuscript or the decision to submit the manuscript. Detailed acknowledgments for the dbGaP data sets are provided in the Supplementary Note.

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Authors and Affiliations

1. Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
   Virginia Perez-Andreu, Wenjian Yang, Heng Xu, Shuyu E, Joshua Yew-Suang Lim, Colton Smith, William E Evans, Mary V Relling & Jun J Yang
2. Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
   Kathryn G Roberts & Charles G Mullighan
3. Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA
   Richard C Harvey, I-Ming Chen & Cheryl L Willman
4. Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
   Cheng Cheng & Deqing Pei
5. Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA
   Julie Gastier-Foster
6. Department of Pediatrics, Ohio State University School of Medicine, Columbus, Ohio, USA
   Julie Gastier-Foster
7. Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
   Joshua Yew-Suang Lim
8. Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
   Yiping Fan
9. Department of Epidemiology and Health Policy Research, University of Florida, Gainesville, Florida, USA
   Meenakshi Devidas
10. Johns Hopkins Medical Institute, Baltimore, Maryland, USA
    Michael J Borowitz
11. Hartwell Center for Bioinformatics & Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
    Geoffrey Neale
12. Department of Bioengineering & Therapeutic Science and Medicine, University of California, San Francisco, San Francisco, California, USA
    Esteban G Burchard & Dara G Torgerson
13. Unidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala
    Federico Antillon Klussmann & Cesar Rolando Najera Villagran
14. Department of Pediatric Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Naomi J Winick
15. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Bruce M Camitta
16. New York University Cancer Institute, New York, New York, USA
    Elizabeth Raetz & William L Carroll
17. Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Brent Wood
18. Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Feng Yue
19. Maine Children's Cancer Program, Scarborough, Maine, USA
    Eric Larsen
20. Department of Hematology and Oncology, Cook Children's Medical Center, Fort Worth, Texas, USA
    W Paul Bowman
21. Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA
    Mignon L Loh
22. Laboratory of Experimental Immunology, National Cancer Institute, Frederick, Maryland, USA
    Michael Dean
23. Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
    Deepa Bhojwani & Ching-Hon Pui
24. Department of Hematology and Oncology, Children's Hospital Colorado, University of Colorado, Aurora, Colorado, USA
    Stephen P Hunger

Authors

1. Virginia Perez-Andreu
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2. Kathryn G Roberts
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3. Richard C Harvey
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4. Wenjian Yang
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5. Cheng Cheng
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6. Deqing Pei
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7. Heng Xu
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8. Julie Gastier-Foster
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9. Shuyu E
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10. Joshua Yew-Suang Lim
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11. I-Ming Chen
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12. Yiping Fan
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13. Meenakshi Devidas
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14. Michael J Borowitz
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15. Colton Smith
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16. Geoffrey Neale
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17. Esteban G Burchard
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18. Dara G Torgerson
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19. Federico Antillon Klussmann
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20. Cesar Rolando Najera Villagran
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21. Naomi J Winick
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22. Bruce M Camitta
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23. Elizabeth Raetz
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24. Brent Wood
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25. Feng Yue
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26. William L Carroll
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27. Eric Larsen
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28. W Paul Bowman
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29. Mignon L Loh
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30. Michael Dean
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31. Deepa Bhojwani
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32. Ching-Hon Pui
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33. William E Evans
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34. Mary V Relling
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35. Stephen P Hunger
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36. Cheryl L Willman
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37. Charles G Mullighan
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38. Jun J Yang
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Contributions

J.J.Y. supervised the research. V.P.-A., S.P.H., C.L.W., C.G.M. and J.J.Y. conceived and designed the experiments. V.P.-A., K.G.R., R.C.H., J.G.-F., S.E., I.-M.C., G.N., E.G.B., D.G.T. and C.R.N.V. performed the experiments. V.P.-A., J.J.Y., R.C.H., W.Y., C.C., D.P., Y.F., M. Devidas, C.S. and G.N. performed statistical analysis. V.P.-A., K.G.R., R.C.H., W.Y., H.X., S.E., J.Y.-S.L., I.-M.C., Y.F., M.J.B., C.S., G.N., E.G.B., D.G.T., F.A.K., C.R.N.V., M.L.L., M. Devidas, D.B., C.-H.P., W.E.E., M.V.R., S.P.H., C.L.W. and C.G.M. analyzed the data. R.C.H., J.G.-F., J.Y.-S.L., Y.F., E.G.B., F.A.K., C.R.N.V., N.J.W., B.M.C., E.R., B.W., F.Y., W.L.C., E.L., W.P.B., M.L.L., M. Dean, S.P.H., C.L.W. and C.G.M. contributed reagents, materials and/or analysis tools. V.P.-A. and J.J.Y. wrote the manuscript.

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Correspondence toJun J Yang.

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Perez-Andreu, V., Roberts, K., Harvey, R. et al. Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse.Nat Genet 45, 1494–1498 (2013). https://doi.org/10.1038/ng.2803

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• Received: 25 May 2013
• Accepted: 27 September 2013
• Published: 20 October 2013
• Issue Date: December 2013
• DOI: https://doi.org/10.1038/ng.2803