New susceptibility locus for coronary artery disease on chromosome 3q22.3 (original) (raw)

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Acknowledgements

We thank J. Stegmann, A. Medack, S. Wrobel and A. Thiemig for assistance. We thank M. Scholz and J. Neudert (Trium Analysis Online GmbH, Munich, Germany) for database management. The German Study was supported by the Deutsche Forschungsgemeinschaft and the German Federal Ministry of Education and Research (BMBF) in the context of the German National Genome Research Network (NGFN-2 and NGFN-plus). The WTCCC Study was funded by the Wellcome Trust. Recruitment of cases for the WTCCC Study was carried out by the British Heart Foundation (BHF) Family Heart Study Research Group and supported by the BHF and the UK Medical Research Council. We also acknowledge support of the Wellcome Trust Functional Genomics Initiative in Cardiovascular Genetics. The KORA research platform (KORA, Cooperative Research in the Region of Augsburg) was initiated and financed by the GSF-National Research centre for Environment and Health, which is funded by the German Federal Ministry of Education and Research and of the State of Bavaria. N.J.S. and S.G.B. are supported by Chairs funded by the BHF. Recruitment for the Italian Atherosclerosis, Thrombosis and Vascular Biology Working Group was supported by the “Associazione per lo Studio della Trombosi in Cardiologia.” The MIGen/IATVB genotyping was supported by a grant to D. Altshuler (R01HL087676) from the STAMPEED program of the National Heart, Lung, and Blood Institute, US National Institutes of Health. In addition, the MIGen study was supported by grants from the Fannie Rippel Foundation (to S.K.) and the Doris Duke Charitable Foundation (to S.K.). The Broad Institute Center for Genotyping and Analysis subsidized genotyping in the MIGen study with support from the National Center for Research Resources (U54RR020278). The main sponsor of the current analysis is the EU-funded integrated project Cardiogenics (LSHM-CT-2006-037593).

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Authors and Affiliations

1. Medizinische Klinik II, Universität zu Lübeck, Lübeck, 23538, Germany
   Jeanette Erdmann, Anika Großhennig, Patrick Linsel-Nitschke, Petra Bruse, Zouhair Aherrahrou, Arnika K Wagner & Heribert Schunkert
2. Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Lübeck, 23538, Germany
   Anika Großhennig, Inke R König, Arne Schillert, Daniel F Schwarz & Andreas Ziegler
3. Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, LE3 9QP, UK
   Peter S Braund & Nilesh J Samani
4. Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, Regensburg, 93053, Germany
   Christian Hengstenberg, Klaus Stark & Marcus Fischer
5. LIGHT, University of Leeds, Leeds, LS1 3EX, UK
   Alistair S Hall, Stephen G Ball & Anthony J Balmforth
6. Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA
   Sekar Kathiresan
7. Departments of Health Sciences and Genetics, University of Leicester, Leicester, LE1 7RH, UK
   Ben Wright & John R Thompson
8. Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche UMR_S 525, Université Pierre et Marie Curie (UPMC) Univ. Paris 06, Paris, France
   David-Alexandre Trégouët, Francois Cambien, Laurence Tiret & Claire Perret
9. Departments of Epidemiology and General Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, 98109, Washington, USA
   Stephen M Schwartz & David S Siscovick
10. Department of Health Promotion and Chronic Disease Prevention, Chronic Disease Epidemiology Unit, National Public Health Institute, Helsinki, FI-00271, Finland
    Veikko Salomaa
11. Cardiovascular Epidemiology and Genetics Group, Institut Municipal d'Investigació Mèdica, Barcelona 08036; Ciber Epidemiología y Salud Pública (CIBERSP), Spain
    Roberto Elosua
12. Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö, SE-20502, Sweden
    Olle Melander
13. Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA
    Benjamin F Voight
14. National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Bethesda, Maryland, 20824, USA
    Christopher J O'Donnell
15. The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, UK
    Leena Peltonen & Panos Deloukas
16. Department of Molecular Biology and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA
    David Altshuler
17. Division of Cardiology, Azienda Ospedaliera Niguarda Ca' Granda, Milan, 20162, Italy
    Piera Angelica Merlini
18. Department of Internal Medicine and Medical Specialities, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore, Mangiagalli e Regina Elena, University of Milan, Milan, 20162, Italy
    Flora Peyvandi
19. Department of Applied Health Sciences, University of Pavia, 27100, Italy
    Luisa Bernardinelli
20. Biostatistics Unit, Medical Research Council, Cambridge, CB2 0SR, UK
    Luisa Bernardinelli
21. Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Parma, 43100, Italy
    Diego Ardissino
22. Department of Medicine II, Johannes Gutenberg-University, Mainz, 55099, Germany
    Stefan Blankenberg, Tanja Zeller & Philipp Wild
23. Institut für Klinische Molekularbiologie, Christian-Albrechts Universität, Kiel, 24118, Germany
    Stefan Schreiber, Nour Eddine El Mokhtari & Arne Schäfer
24. Synlab Centre of Laboratory Diagnostics Heidelberg, Heidelberg, 69037, Germany
    Winfried März
25. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, 8036, Austria
    Winfried März & Wilfried Renner
26. Department of Public Health, Social and Preventive Medicine, University of Heidelberg 69117 Heidelberg, Medical Faculty of Mannheim, Mannheim, 68131, Germany
    Winfried März
27. Institute of Transfusion Medicine and Immunology, University of Heidelberg 69117 Heidelberg, Medical Faculty of Mannheim, Mannheim, 68131, Germany
    Peter Bugert & Harald Klüter
28. Bundesforschungsanstalt für Ernährung und Lebensmittel, Institut für Physiologie und Biochemie der Ernährung, Kiel, 24118, Germany
    Jürgen Schrezenmeir & Diana Rubin
29. Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, 85764, Germany
    H-Erich Wichmann, Christa Meisinger, Jens Baumert & Annette Peters
30. Institute of Medical Information Science, Biometry and Epidemiology, Munich, LMU 80539, Germany
    H-Erich Wichmann
31. Institut für Humangenetik, Helmholtz Zentrum München, Deutsches Forschungszentrum für Umwelt und Gesundheit, Neuherberg, 85764, Germany
    Thomas Meitinger
32. Institut für Humangenetik, Technische Universität München, München, 80333, Germany
    Thomas Meitinger
33. Department of Haematology, University of Cambridge, Long Road, Cambridge, CB2 2PT, UK
    Willem H Ouwehand

Authors

1. Jeanette Erdmann
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2. Anika Großhennig
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3. Peter S Braund
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4. Inke R König
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5. Christian Hengstenberg
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6. Alistair S Hall
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7. Patrick Linsel-Nitschke
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8. Sekar Kathiresan
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9. Ben Wright
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10. David-Alexandre Trégouët
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11. Francois Cambien
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12. Petra Bruse
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13. Zouhair Aherrahrou
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14. Arnika K Wagner
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15. Klaus Stark
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16. Stephen M Schwartz
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17. Veikko Salomaa
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18. Roberto Elosua
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19. Olle Melander
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20. Benjamin F Voight
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21. Christopher J O'Donnell
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22. Leena Peltonen
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23. David S Siscovick
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24. David Altshuler
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25. Piera Angelica Merlini
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26. Flora Peyvandi
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27. Luisa Bernardinelli
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28. Diego Ardissino
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29. Arne Schillert
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30. Stefan Blankenberg
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31. Tanja Zeller
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32. Philipp Wild
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33. Daniel F Schwarz
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34. Laurence Tiret
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35. Claire Perret
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36. Stefan Schreiber
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37. Nour Eddine El Mokhtari
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38. Arne Schäfer
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39. Winfried März
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40. Wilfried Renner
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41. Peter Bugert
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42. Harald Klüter
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43. Jürgen Schrezenmeir
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44. Diana Rubin
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45. Stephen G Ball
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46. Anthony J Balmforth
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47. H-Erich Wichmann
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48. Thomas Meitinger
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49. Marcus Fischer
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50. Christa Meisinger
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51. Jens Baumert
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52. Annette Peters
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53. Willem H Ouwehand
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54. Panos Deloukas
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55. John R Thompson
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56. Andreas Ziegler
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57. Nilesh J Samani
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58. Heribert Schunkert
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Consortia

Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group

Myocardial Infarction Genetics Consortium

Wellcome Trust Case Control Consortium

Cardiogenics Consortium

Contributions

The study was designed by H.S., N.J.S., A.Z., I.R.K., J.R.T. and J.E. Subject ascertainment, recruitment and medical record review was organized and carried out by C.H., P.L.-N. and M.F. DNA material collection, handling and genotyping (Affymetrix 500K, 6.0, and TaqMan) was supervised by P.D., T.M., P. Bruse, W.H.O., P.S.B., K.S., C.P. and A. Schäfer Statistical analysis was carried out by A.G., D.F.S., I.R.K., B.W., A. Schillert, D.-A.T., J.R.T. and A.Z. RT-PCRs were carried out by Z.A. and A.K.W., J.E., N.J.S and H.S. drafted the manuscript with substantial contributions from I.R.K, A.G. and A.Z. Principal collaborators for the case cohorts were W.M. and W.R. (LURIC), H.K. and P. Bugert (GerBS), P.L.-N. (Angio-Luebeck), N.E.M., S.S., J.S. and D.R. (PopGen), H.-E.W., T.M., C.M., A.P., and J.B. (KORA), N.J.S., A.S.H., S.G.B., P.S.B. and A.J.B. (UKMI), C.H., M.F., K.S. (GO-KARD), S.K., D. Altshuler, B.F.V., D. Ardissino, O.M., C.J.O´D., R.E., V.S., L.P., D.S.S. and S.M.S. (MIGen), P.A.M., F.P., L.B. and D. Ardissino (IATVB), S.B., T.Z. and P.W. (Atherogene), L.T., C.P. and F.C. (ECTIM). All authors contributed to the final version of the manuscript.

Corresponding author

Correspondence toJeanette Erdmann.

Additional information

A full list of members is provided in the Supplementary Note.

A full list of members is provided in the Supplementary Note.

A full list of members is provided in the Supplementary Note.

A full list of members is provided in the Supplementary Note.

Supplementary information

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Erdmann, J., Großhennig, A., Braund, P. et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3.Nat Genet 41, 280–282 (2009). https://doi.org/10.1038/ng.307

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• Received: 19 August 2008
• Accepted: 01 December 2008
• Published: 08 February 2009
• Issue Date: March 2009
• DOI: https://doi.org/10.1038/ng.307