Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma (original) (raw)

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Acknowledgements

We thank M. Xu, J. Polite, I. Cardenas-Navia, D. Leja and I. Ginty for technical assistance. We thank R. Weinberg (Massachusetts Institute of Technology) for the Mel-STR cells, and W. Gahl (National Institutes of Health) and R. Alani (Johns Hopkins University) for normal melanocyte RNA. We also thank L. Matrisian, P. Meltzer, T. Waldman, G. Merlino, T. Hornyak and T. Bugge for their comments on the manuscript. Funded by the National Human Genome Research Institute and National Institute on Aging.

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Authors and Affiliations

1. National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
   Lavanya H Palavalli, Todd D Prickett, Xiaomu Wei, Allison S Burrell, Patricia Porter-Gill, Chenwei Wang, Julia C Cronin, Neena S Agrawal, Wendy Westbroek, Shelley Hoogstraten-Miller, Lawrence C Brody & Yardena Samuels
2. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
   John R Wunderlich, Sean Davis, Patricia Fetsch, Armando C Filie & Steven A Rosenberg
3. The Ludwig Center for Cancer Genetics and Therapeutics, the Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA
   Jimmy C Lin
4. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
   Alfredo A Molinolo
5. Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
   Michael P O'Connell & Ashani T Weeraratna
6. University of South Carolina School of Medicine, Columbia, South Carolina, USA
   Carolyn E Banister & Phillip Buckhaults
7. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
   Jason D Howard

Authors

1. Lavanya H Palavalli
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2. Todd D Prickett
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3. John R Wunderlich
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4. Xiaomu Wei
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5. Allison S Burrell
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6. Patricia Porter-Gill
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7. Sean Davis
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8. Chenwei Wang
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9. Julia C Cronin
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10. Neena S Agrawal
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11. Jimmy C Lin
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12. Wendy Westbroek
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13. Shelley Hoogstraten-Miller
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14. Alfredo A Molinolo
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15. Patricia Fetsch
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16. Armando C Filie
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17. Michael P O'Connell
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18. Carolyn E Banister
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19. Jason D Howard
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20. Phillip Buckhaults
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21. Ashani T Weeraratna
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22. Lawrence C Brody
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23. Steven A Rosenberg
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24. Yardena Samuels
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Contributions

L.H.P. and Y.S. designed the study; J.R.W., P.F., A.C.F. and S.A.R. collected and analyzed the melanoma samples, A.S.B., J.C.C., N.S.A., P.B., P.P.-G., S.D., C.W., C.E.B., J.C.L. and Y.S. analyzed the genetic data; L.H.P., T.D.P., X.W., W.W., S.H.-M., A.A.M., M.P.O., J.D.H. and A.T.W. performed and analyzed the functional data. All authors contributed to the final version of the paper.

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Correspondence toYardena Samuels.

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Palavalli, L., Prickett, T., Wunderlich, J. et al. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.Nat Genet 41, 518–520 (2009). https://doi.org/10.1038/ng.340

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• Received: 10 October 2008
• Accepted: 02 February 2009
• Published: 29 March 2009
• Issue Date: May 2009
• DOI: https://doi.org/10.1038/ng.340