Genome-wide association study identifies 112 new loci for body mass index in the Japanese population (original) (raw)

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Acknowledgements

We would like to acknowledge the staff of the TMM, the JPHC and the BBJ for collecting samples and clinical information. We are grateful to the staff of the RIKEN Center for Integrative Medical Sciences for genotyping and data management. We thank S.K. Low, K. Suzuki and M. Horikoshi for advice on statistical analyses, and A.P. Morris for providing us with the MANTRA software. This study was funded by the BioBank Japan project (M.A., Y.O., M. Kanai, A.T., Y.M., M.H., K.M., M. Kubo and Y.K.) and Tohoku Medical Megabank project (T.H., K.T., A.S., A.H., N.M. and M.Y.), which is supported by the Ministry of Education, Culture, Sports, Sciences and Technology of Japanese government and the Japan Agency for Medical Research and Development. The JPHC Study has been supported by the National Cancer Research and Development Fund (2010–present) and a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan (1989–2010) (M. Iwasaki., T.Y., N.S. and S.T.). GWAS of psychiatric disorders were the results of the Strategic Research Program for Brain Sciences (SRPBS) from the Japan Agency for Medical Research and Development (A.T., M. Ikeda, N.I., M. Kubo and Y.K.).

Author information

Authors and Affiliations

  1. Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
    Masato Akiyama, Yukinori Okada, Masahiro Kanai, Atsushi Takahashi & Yoichiro Kamatani
  2. Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan
    Yukinori Okada
  3. Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan
    Yukinori Okada
  4. Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan
    Atsushi Takahashi
  5. Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
    Yukihide Momozawa
  6. Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
    Masashi Ikeda & Nakao Iwata
  7. Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan
    Shiro Ikegawa
  8. Institute of Medical Science, the University of Tokyo, Tokyo, Japan
    Makoto Hirata
  9. Graduate school of Frontier Sciences, the University of Tokyo, Tokyo, Japan
    Koichi Matsuda
  10. Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
    Motoki Iwasaki, Taiki Yamaji & Norie Sawada
  11. Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan
    Tsuyoshi Hachiya, Kozo Tanno & Atsushi Shimizu
  12. Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Iwate, Japan
    Kozo Tanno
  13. Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
    Atsushi Hozawa, Naoko Minegishi & Masayuki Yamamoto
  14. Graduate School of Medicine, Tohoku University, Sendai, Japan
    Atsushi Hozawa, Naoko Minegishi & Masayuki Yamamoto
  15. Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
    Shoichiro Tsugane
  16. RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
    Michiaki Kubo
  17. Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Yoichiro Kamatani

Authors

  1. Masato Akiyama
  2. Yukinori Okada
  3. Masahiro Kanai
  4. Atsushi Takahashi
  5. Yukihide Momozawa
  6. Masashi Ikeda
  7. Nakao Iwata
  8. Shiro Ikegawa
  9. Makoto Hirata
  10. Koichi Matsuda
  11. Motoki Iwasaki
  12. Taiki Yamaji
  13. Norie Sawada
  14. Tsuyoshi Hachiya
  15. Kozo Tanno
  16. Atsushi Shimizu
  17. Atsushi Hozawa
  18. Naoko Minegishi
  19. Shoichiro Tsugane
  20. Masayuki Yamamoto
  21. Michiaki Kubo
  22. Yoichiro Kamatani

Contributions

M.A., Y.K. and M. Kubo conceived and designed the study. K.M., M.H. and M. Kubo collected and managed the BBJ sample. M. Iwasaki, T.Y., N.S. and S.T. collected and managed JPHC sample and information. T.H., K.T., A.S., A.H., N.M. and M.Y. collected and managed the TMM sample. Y.M. and M. Kubo performed genotyping. M.A., M. Kanai, Y.K. and A.T. performed statistical analysis. S.I., M. Ikeda and N.I. contributed to data acquisition. Y.O., A.T., Y.K. and M. Kubo supervised the study. M.A., Y.O., Y.K. and M. Kubo wrote the manuscript.

Corresponding author

Correspondence toYoichiro Kamatani.

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Competing interests

The authors declare no competing financial interests.

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Akiyama, M., Okada, Y., Kanai, M. et al. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.Nat Genet 49, 1458–1467 (2017). https://doi.org/10.1038/ng.3951

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