Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis (original) (raw)

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Acknowledgements

This research was supported by grants from the Canadian Institutes for Health Research (MOP 74621), the Ontario Research Fund (RE01-061), the Canadian Primary Biliary Cirrhosis Society, the Canadian Foundation for Innovation, the Ben and Hilda Katz Charitable Foundation, the US National Institutes of Health (K23 DK68290, RO3 DK78527 and RO1 DK80670), the American Gastroenterological Association and the A.J. and Sigismunda Palumbo Charitable Trust. K.A.S. is a recipient of a Canada Research Chair award. We thank all the study subjects and supporting physicians as well as the technical staff of the University Health Network Analytical Genetics Technology Centre for their assistance in this research.

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Authors and Affiliations

1. Liver Centre, Toronto Western Hospital, Toronto, Ontario, Canada
   Gideon M Hirschfield, Catalina Coltescu & E Jenny Heathcote
2. Department of Medicine, University of Toronto, Toronto, Ontario, Canada
   Gideon M Hirschfield, Xiangdong Liu, Yan Lu, Chun Xu, Jinyi Zhang, E Jenny Heathcote & Katherine A Siminovitch
3. Mount Sinai Hospital, Samuel Lunenfeld Research Institute and Toronto General Research Institute, Toronto, Ontario, Canada
   Xiangdong Liu, Yan Lu, Chun Xu, Jinyi Zhang & Katherine A Siminovitch
4. Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
   Younghun Han, Ivan P Gorlov, Yue Lu, Wei Chen & Christopher I Amos
5. Division of Gastroenterology and Hepatology, Center for Basic Research in Digestive Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
   Brian D Juran & Konstantinos N Lazaridis
6. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
   Andrew L Mason
7. Liver Unit, Pomeranian Medical School, Szczecin, Poland
   Piotr Milkiewicz
8. Liver Unit, University of Calgary, Calgary, Alberta, Canada
   Robert P Myers
9. Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York, USA
   Joseph A Odin
10. Department of Gastroenterology, Virginia Commonwealth University, Richmond, Virginia, USA
    Velimir A Luketic
11. Centre of Gastroenterology and Dietetics, Vilnius University, Lithuania
    Danute Speiciene
12. Université de Montréal Hospital Centre, Saint-Luc Hospital, Montréal, Quebec, Canada
    Catherine Vincent
13. Division of Gastroenterology, Department of Medicine, Hepatology and Nutrition, University of Florida, Gainesville, Florida, USA
    Cynthia Levy
14. Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, USA
    Peter K Gregersen
15. Departments of Immunology and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Katherine A Siminovitch

Authors

1. Gideon M Hirschfield
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2. Xiangdong Liu
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3. Younghun Han
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4. Ivan P Gorlov
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5. Yan Lu
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6. Chun Xu
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7. Yue Lu
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8. Wei Chen
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9. Brian D Juran
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10. Catalina Coltescu
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11. Andrew L Mason
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12. Piotr Milkiewicz
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13. Robert P Myers
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14. Joseph A Odin
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15. Velimir A Luketic
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16. Danute Speiciene
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17. Catherine Vincent
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18. Cynthia Levy
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19. Peter K Gregersen
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20. Jinyi Zhang
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21. E Jenny Heathcote
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22. Konstantinos N Lazaridis
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23. Christopher I Amos
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24. Katherine A Siminovitch
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Contributions

G.M.H., X.L., C.I.A. and K.A.S. designed the study. X.L., Y.H., I.P.G., Y.L., C.X., Y.L., W.C., J.Z. and C.I.A. performed the genotyping and data analysis. G.M.H., B.D.J., C.C., A.L.M., P.M., R.P.M., J.A.O., V.A.L., D.S., C.V., C.L., P.K.G., E.J.H., K.N.L. and K.A.S. developed the clinical network and sample collection and processing framework required for case and control accrual. G.M.H., C.I.A. and K.A.S. wrote the manuscript. G.M.H., X.L., C.I.A. and K.A.S. vouch for the data and its analysis. G.M.H., C.I.A. and K.A.S. (the senior and corresponding author) decided in agreement with all other authors to publish this paper.

Corresponding author

Correspondence toKatherine A Siminovitch.

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Competing interests

G.M.H. reports receiving lecture and consultancy fees from Axcan Pharma and A.L.M. received grant support from Novartis and Schering-Plough. J.H. reports receiving lecture fees and grant support from Axcan Pharma.

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Hirschfield, G., Liu, X., Han, Y. et al. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.Nat Genet 42, 655–657 (2010). https://doi.org/10.1038/ng.631

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• Received: 19 January 2010
• Accepted: 22 June 2010
• Published: 18 July 2010
• Issue Date: August 2010
• DOI: https://doi.org/10.1038/ng.631