Common variants at 19p13 are associated with susceptibility to ovarian cancer (original) (raw)

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In the version of this article initially published, the name of author Angela Brooks-Wilson was spelled incorrectly in the author list. The error has been corrected in the HTML and PDF versions of the article.

Nat. Genet. 42, 880–884 (2010); published online 19 September 2010; corrected after print 7 December 2015 In the version of this article initially published, the name of author Angela Brooks-Wilson was spelled incorrectly in the author list. The error has been corrected in the HTML and PDF versions of the article.

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Acknowledgements

We thank all the individuals who took part in this study and all the researchers, clinicians and administrative staff who have made possible the many studies contributing to this work. In particular we thank A. Ryan and J. Ford (United Kingdom Ovarian Cancer Population Study (UKOPS)); J. Morrison, P. Harrington and the Studies of Epidemiology and Risk Factors in Cancer Heredity (SEARCH) team (SEA); U. Eilber and T. Koehler (German Ovarian Cancer Study (GER)); D. Bowtell, A. deFazio, D. Gertig and A. Green (Australian Ovarian Cancer Study (AOCS)); A. Green, P. Parsons, N. Hayward and D. Whiteman (Australian Cancer Study (ACS)); L. Gacucova (Hannover-Minsk Ovarian Cancer Study (HMOCS)); S. Haubold, P. Schürmann, F. Kramer, W. Zheng, T.-W. Park-Simon, K. Beer-Grondke and D. Schmidt (Hannover-Jena Ovarian Cancer Study (HJOCS)); and L. Brinton, M. Sherman, A. Hutchinson, N. Szeszenia-Dabrowska, B. Peplonska, W. Zatonski, A. Soni, P. Chao and M. Stagner (NCI Ovarian Cancer Case-Control Study in Poland (POL2)).

The genotyping and data analysis for this study was supported by a project grant from Cancer Research UK. We acknowledge the computational resources provided by the University of Cambridge (CamGrid). This study makes use of data generated by the Wellcome Trust Case-Control consortium. A full list of the investigators who contributed to the generation of the data is available from http://www.wtccc.org.uk/. Funding for the project was provided by the Wellcome Trust under award 076113. The Ovarian Cancer Association Consortium is supported by a grant from the Ovarian Cancer Research Fund thanks to donations by the family and friends of K. Sladek Smith. The results published here are in part based upon data generated by The Cancer Genome Atlas Pilot Project established by the National Cancer Institute and National Human Genome Research Institute. Information about TCGA and the investigators and institutions who constitute the TCGA research network can be found at http://cancergenome.nih.gov/. S.J.R. is supported by the Mermaid/Eve Appeal. G.C.-T. and P.M.W. are supported by the National Health and Medical Research Council. P.A.F. is supported by the Deutsche Krebshilfe. M.E.G. acknowledges National Health Service funding to the National Institutes of Health Research Centre at the Royal Marsden Hospital, and D.F.E. is a Principal Research Fellow of Cancer Research UK. Funding of the constituent studies was provided by the Danish Cancer Society, the Ovarian Cancer Research Fund (PPD/RPCI.07), the Roswell Park Cancer Institute Alliance Foundation, the US National Cancer Institute (CA58860, CA92044, P50CA105009, R01CA122443, R01CA126841-01, R01CA16056, R01CA61107, R01CA71766, R01CA054419, R01CA114343, R01CA87538, R01CA112523, R01CA58598, N01CN55424, N01PC35137 and Intramural research funds), the US Army Medical Research and Material Command (DAMD17-01-1-0729), Cancer Council Victoria, Cancer Council Queensland, Cancer Council New South Wales, Cancer Council South Australia, Cancer Council Tasmania and Cancer Foundation of Western Australia, the National Health and Medical Research Council of Australia (199600 and 400281), the German Federal Ministry of Education and Research of Germany Programme of Clinical Biomedical Research (01 GB 9401), the state of Baden-Württemberg through Medical Faculty of the University of Ulm (P.685), the Mayo Foundation, the Lon V. Smith Foundation (LVS-39420), the Oak Foundation, the University College Hospital National Institute for Health Research Biomedical Research Centre and the Royal Marsden Hospital Biomedical Research Centre.

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Author notes

  1. Kelly L Bolton and Jonathan Tyrer: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Oncology, University of Cambridge, Cambridge, UK
    Kelly L Bolton, Jonathan Tyrer, Honglin Song, Douglas F Easton & Paul D P Pharoah
  2. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Kelly L Bolton, Hanna P Yang, Stephen Chanock & Montserrat Garcia-Closas
  3. Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women's Health, London, UK
    Susan J Ramus, Maria Notaridou, Chris Jones, Tanya Sher, Aleksandra Gentry-Maharaj, Eva Wozniak & Simon A Gayther
  4. H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Ya-Yu Tsai, Catherine Phelan & Tom Sellers
  5. Department of Therapeutic Radiology, Yale University, New Haven, Connecticut, USA
    Joanne Weidhaas
  6. Department of Obstetrics and Gynecology, Yale University, New Haven, Connecticut, USA
    Daniel Paik
  7. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    David J Van Den Berg, Daniel O Stram, Celeste Leigh Pearce & Anna H Wu
  8. Department of Epidemiology, School of Medicine, University of California, Irvine, California, USA
    Wendy Brewster, Hoda Anton-Culver & Argyrios Ziogas
  9. Center for Research in Women's Health, Toronto, Canada
    Steven A Narod
  10. Department of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
    Douglas A Levine
  11. Section of Medicine, Institute of Cancer Research, Sutton, UK
    Stanley B Kaye
  12. Department of Surgery and Cancer, Imperial College London, London, UK
    Robert Brown & James Flanagan
  13. Cancer Research UK Clinical Trials Unit, Glasgow University, Glasgow, UK
    Jim Paul
  14. Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
    Weiva Sieh, Valerie McGuire & Alice S Whittemore
  15. Peter MacCallum Cancer Institute, Melbourne, Australia
    Ian Campbell
  16. The Royal Marsden Hospital, Gynecological Oncology Unit, London, UK
    Martin E Gore
  17. Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland
    Jolanta Lissowska
  18. Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland
    Krzysztof Medrek, Jacek Gronwald, Jan Lubinski & Anna Jakubowska
  19. Cancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Nhu D Le
  20. Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque, New Mexico, USA
    Linda S Cook
  21. Alberta Health Services-Cancer Care, Calgary, Alberta, Canada
    Linda S Cook & Linda E Kelemen
  22. Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Angela Brooks-Wilson
  23. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada
    Angela Brooks-Wilson
  24. Department of Gynaecology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Leon F A G Massuger, Lambertus A Kiemeney & Anne M van Altena
  25. Comprehensive Cancer Center East, Nijmegen, The Netherlands
    Katja K H Aben
  26. Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK
    Richard Houlston
  27. Population and Functional Genetics Lab, Wellcome Trust Centre for Human Genetics, Oxford, UK
    Ian Tomlinson
  28. Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Rachel T Palmieri, Patricia G Moorman, Joellen Schildkraut & Andrew Berchuck
  29. Department of Statistics, Duke University, Durham, North Carolina, USA
    Edwin S Iversen
  30. Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Robert A Vierkant, Ellen L Goode & Brooke L Fridley
  31. Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Julie M Cunningham
  32. Department of Virus, Hormones and Cancer Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Susan Kruger-Kjaer & Estrid Hogdall
  33. Aarhus University Hospital, Skejby, Aarhus, Denmark
    Jan Blaeker
  34. The Gynaecologic Clinic, The Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    Claus Hogdall
  35. Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, California, USA
    Jenny Gross & Beth Y Karlan
  36. University of Texas School of Public Health, Houston, Texas, USA
    Roberta B Ness
  37. Magee-Womens Hospital, Pittsburgh, Pennsylvania, USA
    Robert P Edwards
  38. Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Kunle Odunsi
  39. Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, USA
    Kirsten B Moyisch
  40. Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island, USA
    Julie A Baker
  41. Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Francesmary Modugno
  42. Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Tuomas Heikkinenen, Ralf Butzow, Heli Nevanlinna & Arto Leminen
  43. Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N, Minsk, Belarus
    Natalia Bogdanova & Natalia Antonenkova
  44. Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
    Thilo Doerk & Peter Hillemanns
  45. Clinics of Obstetrics and Gynaecology, Friedrich Schiller University, Jena, Germany
    Matthias Dürst & Ingo Runnebaum
  46. Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, USA
    Pamela J Thompson, Michael E Carney, Marc T Goodman & Galina Lurie
  47. Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany
    Shan Wang-Gohrke
  48. Division of Cancer Epidemiology, Unit of Genetic Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Rebecca Hein & Jenny Chang-Claude
  49. Program in Epidemiology, Fred Hutchinson Cancer Research Center,, Seattle, Washington, USA
    Mary Anne Rossing, Kara L Cushing-Haugen, Jennifer Doherty & Chu Chen
  50. deCODE Genetics, Reykjavik, Iceland
    Thorunn Rafnar, Soren Besenbacher, Patrick Sulem & Kari Stefansson
  51. Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Michael J Birrer
  52. Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts, USA
    Kathryn L Terry & Daniel W Cramer
  53. National Institute of Aging, National Institutes of Health, Bethesda, Maryland, USA
    Dena Hernandez
  54. Department of Gynaecologic Oncology, University Hospitals Leuven, Leuven, Belgium
    Ignace Vergote, Frederic Amant & Evelyn Despierre
  55. Vesalius Research Center, VIB and K.U.Leuven, Leuven, Belgium
    Diether Lambrechts
  56. Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, Los Angeles, California, USA
    Peter A Fasching
  57. Department of Cancer Epidemiology and Prevention, The M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland
    Matthias W Beckmann
  58. Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany
    Falk C Thiel
  59. Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany
    Arif B Ekici
  60. The Queensland Institute of Medical Research,
    Xiaoqing Chen, Sharon E Johnatty, Penelope M Webb, Jonathan Beesley & Georgia Chenevix-Trench
  61. Post Office Royal Brisbane Hospital, Australia
    Xiaoqing Chen, Sharon E Johnatty, Penelope M Webb, Jonathan Beesley & Georgia Chenevix-Trench

Authors

  1. Kelly L Bolton
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  2. Jonathan Tyrer
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  3. Honglin Song
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  4. Susan J Ramus
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  5. Maria Notaridou
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  6. Chris Jones
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  8. Aleksandra Gentry-Maharaj
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  11. Joanne Weidhaas
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  38. Linda S Cook
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  39. Linda E Kelemen
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  40. Angela Brooks-Wilson
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  41. Leon F A G Massuger
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  42. Lambertus A Kiemeney
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  43. Katja K H Aben
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  44. Anne M van Altena
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  45. Richard Houlston
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  46. Ian Tomlinson
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Consortia

the Australian Ovarian Cancer Study Group

the Australian Cancer Study (Ovarian Cancer)

on behalf of the Ovarian Cancer Association Consortium

Contributions

P.D.P.P., S.A.G. and D.F.E. designed the overall study and obtained financial support. P.D.P.P., S.A.G., S.J.R. and H.S. coordinated the studies used in phase 1 and phase 2. H.S., K.L.B., G.C.-T. and E.L.G. coordinated phase 3. J.T. and K.L.B. conducted primary phase 1 and phase 2 analysis and phase 3 SNP selection. K.L.B. conducted phase 3 and combined data statistical analyses. H.S., J.B. and J.M.C. conducted phase 3 genotyping. S.A.G., M.N., C.J. and T.S. designed and performed the functional analyses. The remaining authors coordinated contributing studies. K.L.B. and P.D.P.P. drafted the manuscript with substantial input from S.A.G., H.S. and S.J.R. All authors contributed to the final draft.

Corresponding author

Correspondence toPaul D P Pharoah.

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The authors declare no competing financial interests.

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Bolton, K., Tyrer, J., Song, H. et al. Common variants at 19p13 are associated with susceptibility to ovarian cancer.Nat Genet 42, 880–884 (2010). https://doi.org/10.1038/ng.666

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