Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis (original) (raw)

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Acknowledgements

We are grateful to all subjects and control probands for participation in this study. We thank P. Rothe, M. Kirsch, P. Badorf, P. Gilbert and K. Krause for excellent technical assistance. We thank D. Fried for helping with the cloning of constructs. The work was supported in part by a grant from the Interdisciplinary Centre for Clinical Research (IZKF B32/A8) of the University of Erlangen-Nuremberg and a grant from the ELAN fund (Erlanger Leistungsbezogene Anschubfinanzierung und Nachwuchsförderung) of the University of Erlangen-Nuremberg. The KORA (Cooperative Health Research in the Region of Augsburg) research platform was initiated and financed by the Helmholtz Center Munich, German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria. Part of this work was financed by the German National Genome Research Network (NGFN-2 and NGFNPlus: 01GS0823). Our research was supported within the Munich Center of Health Sciences (MC Health) as part of LMUinnovativ. We acknowledge the National Institute for Health Research, Manchester Biomedical Research Centre and Science Foundation Ireland for support. A.B., I.N.B. and J.B. are funded by Arthritis Research. H.B. and F.B. were supported by a research grant of Wyeth Pharma GmbH, Germany (Forschungsförderungspreis Rheumatologie 2008). E.G. and G.N. are funded by the ADIPSO (Association for the Defense of Psoriasis Patients). The Irish control DNA was provided by the Irish Blood Transfusion Service and Trinity College Dublin population DNA Biobank. This study makes use of data generated by the Wellcome Trust Case-Control Consortium. A full list of the investigators who contributed to the generation of the data is available from http://www.wtccc.org.uk. Funding for the project was provided by the Wellcome Trust under award 076113. U.H., E.G., E.K., M.A., P.H., I.N.B., F.B., O.F., G.-M.A., N.J.M., G.N., H.B., A.B. and A.R. are members of the Psoriatic Arthritis Genetics in Europe (PAGE) Consortium.

Author information

Author notes

  1. Jesús Lascorz
    Present address: Present address: Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.,
  2. Ulrike Hüffmeier and Steffen Uebe: These authors contributed equally to this work.
  3. Harald Burkhardt, Anne Barton and André Reis: These authors jointly supervised this work.

Authors and Affiliations

  1. Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany
    Ulrike Hüffmeier, Steffen Uebe, Arif B Ekici, Maria Apel, Jesús Lascorz & André Reis
  2. Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    John Bowes, Pauline Ho, Ian N Bruce & Anne Barton
  3. Department of Biopathology, Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, University of Rome 'Tor Vergata' and Fondazione PTV 'Policlinico Tor Vergata', Rome, Italy
    Emiliano Giardina & Giuseppe Novelli
  4. Royal National Hospital for Rheumatic Diseases, Bath, UK
    Eleanor Korendowych & Neil J McHugh
  5. Department of Public Health and Clinical Medicine, Rheumatology, University Hospital, Umeå, Sweden
    Kristina Juneblad & Gerd-Marie Alenius
  6. Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    Ross McManus & Anthony W Ryan
  7. Division of Rheumatology, Department of Internal Medicine II, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Frank Behrens, Beate Böhm & Harald Burkhardt
  8. Department of Dermatology, University of Münster, Münster, Germany
    Heiko Traupe
  9. Psoriasis Rehabilitation Hospital, Bad Bentheim, Germany
    Jörg Lohmann
  10. Institute of Epidemiology, Helmholtz Center Munich, Munich, Germany
    Christian Gieger & Heinz-Erich Wichmann
  11. Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
    Heinz-Erich Wichmann
  12. Klinikum Grosshadern, Munich, Germany
    Heinz-Erich Wichmann
  13. Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Christine Herold, Michael Steffens & Thomas F Wienker
  14. Karolinska Institute, Stockholm, Sweden
    Lars Klareskog
  15. Department of Rheumatology, St. Vincent's University Hospital, University College Dublin (UCD) School of Medicine and Medical Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    Oliver FitzGerald
  16. Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    Neil J McHugh

Authors

  1. Ulrike Hüffmeier
  2. Steffen Uebe
  3. Arif B Ekici
  4. John Bowes
  5. Emiliano Giardina
  6. Eleanor Korendowych
  7. Kristina Juneblad
  8. Maria Apel
  9. Ross McManus
  10. Pauline Ho
  11. Ian N Bruce
  12. Anthony W Ryan
  13. Frank Behrens
  14. Jesús Lascorz
  15. Beate Böhm
  16. Heiko Traupe
  17. Jörg Lohmann
  18. Christian Gieger
  19. Heinz-Erich Wichmann
  20. Christine Herold
  21. Michael Steffens
  22. Lars Klareskog
  23. Thomas F Wienker
  24. Oliver FitzGerald
  25. Gerd-Marie Alenius
  26. Neil J McHugh
  27. Giuseppe Novelli
  28. Harald Burkhardt
  29. Anne Barton
  30. André Reis

Contributions

H.B., A.B. and A.R. designed the study and worked out its concept. U.H., A.B.E., M.A. and J.B. planned and performed genotyping with genome-wide arrays and/or assays for single SNPs, and U.H., S.U., A.B.E., J.B., M.A., C.H., M.S., T.F.W. and A.R. analyzed genetic data. B.B. and H.B. performed functional studies. U.H., J.B., E.G., E.K., K.J., R.M., P.H., I.N.B., A.W.R., F.B., J. Lascorz, H.T., J. Lohmann, C.G., H.-E.W., O.F., G.-M.A., N.J.M., G.N., H.B. and A.B. recruited subjects and control individuals and collected the phenotypic data. U.H., S.U., H.B. and A.R. wrote a first draft of the manuscript. A.B. edited the manuscript in a major way. All authors reviewed and approved the manuscript.

Corresponding author

Correspondence toAndré Reis.

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Competing interests

The authors declare no competing financial interests.

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Hüffmeier, U., Uebe, S., Ekici, A. et al. Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.Nat Genet 42, 996–999 (2010). https://doi.org/10.1038/ng.688

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