A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer (original) (raw)
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Acknowledgements
This work was supported by a US Department of Defense Breast Cancer Research Program Era of Hope Scholar Award to C.A.H. (W81XWH-08-1-0383), the Norris Foundation, the Mayo Clinic College of Medicine, Komen Foundation for the Cure, the Breast Cancer Research Foundation and US National Institutes of Health grants CA128978, CA122340 and CA148065. Study specific acknowledgments are listed in the Supplementary Note.
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Authors and Affiliations
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, USA
Christopher A Haiman, Gary K Chen, Christopher K Edlund, Andrea Holbrook, Sue A Ingles, Loreall C Pooler, Fredrick Schumacher, Xin Sheng, David Van Den Berg, Peggy Wan, Lucy Y Xia, Daniel O Stram & Brian E Henderson - Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
Celine M Vachon, Timothy Lesnick, Curtis Olswold, Kristen N Stevens, Susan L Slager & Fergus J Couch - Genomic Epidemiology Group, DKFZ, Heidelberg, Germany
Federico Canzian - Centre for Cancer Genetic Epidemiology, Strangeways Laboratory, Worts Causeway, Cambridge, UK
Alison Dunning, Shahana Ahmed, Paul D P Pharoah & Douglas Easton - Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
Robert C Millikan & Sarah Nyante - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
Xianshu Wang & Fergus J Couch - Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA
Foluso Ademuyiwa - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA
Christine B Ambrosone - Cancer Epidemiology Centre, The Cancer Council Victoria & Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Victoria, Australia.,
Laura Baglietto, Graham G Giles & Gianluca Severi - Department of Translational Oncology, Westmead Hospital, Western Sydney Local Health Network, Westmead, New South Wales, Australia
Rosemary Balleine - The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
Elisa V Bandera - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Matthias W Beckmann & Peter A Fasching - Division of Cancer Prevention, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
Christine D Berg - Division of Cancer Etiology, Department of Population Science, Beckman Research Institute, City of Hope, California, USA
Leslie Bernstein - Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
Carl Blomqvist - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
William J Blot, Sandra L Deming, Lisa B Signorello & Wei Zheng - International Epidemiology Institute, Rockville, Maryland, USA
William J Blot & Lisa B Signorello - Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
Hiltrud Brauch - University of Tübingen, Tübingen, Germany
Hiltrud Brauch - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
Julie E Buring & Daniel I Chasman - Department of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
Lisa A Carey - Australian Breast Cancer Tissue Bank, University of Sydney at the Westmead Millennium Institute, Westmead, New South Wales, Australia
Jane E Carpenter & Christine L Clarke - Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
Jenny Chang-Claude, Rebecca Hein & Stephan Nickels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
Stephen J Chanock, Robert N Hoover & Regina G Ziegler - Department of Oncology, Institute for Cancer Studies, Faculty of Medicine, Dentistry & Health, University of Sheffield, Sheffield, UK
Angela Cox - Department of Neuroscience, Academic Unit of Pathology, Faculty of Medicine, Dentistry & Health, University of Sheffield, Sheffield, UK
Simon S Cross - Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA
Robert B Diasio & Adam M Lee - Department of Clinical Therapeutics, “Alexandra” Hospital, University of Athens School of Medicine, Athens, Greece
Athanasios M Dimopoulos - Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA
W Ryan Driver - Molecular Genetics of Breast Cancer, DKFZ, Heidelberg, Germany
Thomas Dünnebier & Ute Hamann - Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK
Lorraine Durcan, Diana Eccles, Susan M Gerty, Nikki Graham & William J Tapper - Institute of Human Genetics, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany
Arif B Ekici - Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California, USA
Peter A Fasching - Kaiser Permanente Colorado, Denver, Colorado, USA
Heather S Feigelson - Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany
Dieter Flesch-Janys & Judith Heinz - Molecular Diagnostics Laboratory Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research “Demokritos”, Athens, Greece
Florentia Fostira, Irene Konstantopoulou & Drakoulis Yannoukakos - Division of Molecular Genetic Epidemiology, DKFZ, Heidelberg, Germany
Asta Försti - Center for Primary Health Care Research, University of Lund, Malmö, Sweden
Asta Försti - Department of Medical Oncology, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece
George Fountzilas - Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Lawrence, Kansas, USA
Andrew K Godwin - Washington University School of Medicine, Barnes-Jewish Hospital and Siteman Cancer Center, St. Louis, Missouri, USA
Paul Goodfellow & Jennifer Ivanovich - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
Dario Greco & Heli Nevanlinna - Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Susan E Hankinson - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Susan E Hankinson, David J Hunter, Sara Lindstrom & Peter Kraft - Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany
Arndt Hartmann & Rüdiger Schulz-Wendtland - Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, Florida, USA
Jennifer J Hu & Jorge L Rodriguez-Gil - Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
David J Hunter, Sara Lindstrom & Peter Kraft - Human Genetics Division, Genome Institute of Singapore, Singapore
Astrid Irwanto & Jianjun Liu - Cancer Prevention Institute of California, Fremont, California
Esther M John - Stanford University School of Medicine and Stanford Cancer Center, Stanford, California, USA
Esther M John - Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
Nicola Johnson - Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland
Arja Jukkola-Vuorinen - Division of Cancer Epidemiology, DKFZ, Heidelberg, Germany
Rudolf Kaaks - Department of Internal Medicine, Evangelische Kliniken Johanniter- und Waldkrankenhaus Bonn gGmbH, Bonn, Germany
Yon-Dschun Ko - Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, USA
Laurence N Kolonel & Loïc Le Marchand - Department of Pathology, Imaging Centre, Kuopio University Hospital, Kuopio, Finland
Veli-Matti Kosma - Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA
Swati Kulkarni - Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
Diether Lambrechts & Els Wauters - Vesalius Research Center, University of Leuven, Leuven, Belgium
Diether Lambrechts & Els Wauters - Department of Pathology, Institute of Clinical Medicine, University of Eastern Finland Biocenter Kuopio, Kuopio, Finland
Arto Mannermaa - Department of Pathology, Imaging Centre, Kuopio University Hospital, Kuopio, Finland
Arto Mannermaa - Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
Sara Margolin - Queensland Institute of Medical Research (QIMR) Genome-Wide Association Study Collective, Brisbane, Queensland, Australia
Nicholas G Martin & Grant W Montgomery - Dana-Farber Cancer Institute, Boston, Massachusetts, USA
Penelope Miron - Slone Epidemiology Center at Boston University, Boston, Massachusetts, USA
Julie Palmer & Lynn Rosenberg - Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Harsh Pathak & JoEllen Weaver - Department of Internal Medicine, Oncology Section, “Hippokration” Hospital, Athens, Greece
Dimitrios Pectasides - Departments of Genetics and Pathology, Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, North Carolina, USA
Charles M Perou - Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
Julian Peto & Isabel dos Santos Silva - Department of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
Michael F Press - Department of Clinical Genetics and Biocenter Oulu, Laboratory of Cancer Genetics, University of Oulu, Oulu University Hospital, Oulu, Finland
Katri Pylkäs & Robert Winqvist - University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Timothy R Rebbeck - Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Eric Ross - Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany
Thomas Rüdiger - National Institute for Health Research Comprehensive Biomedical Research Centre, Guy's & St. Thomas' National Health Service Foundation Trust, London, UK
Elinor Sawyer - Division of Experimental Therapy and Molecular Pathology and Division of Epidemiology, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Marjanka K Schmidt - Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany
Hans-Peter Sinn - Department of Pathology, Genetic Epidemiology Laboratory, The University of Melbourne, Melbourne, Victoria, Australia
Melissa C Southey - Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
Ian Tomlinson - Family Cancer Clinic, Netherlands Cancer Institut–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Frans B L Hogervorst - Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium
Hans Wildiers - Imperial College, London, UK
Afshan Siddiq - Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
Peter Kraft
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The Gene Environment Interaction and Breast Cancer in Germany (GENICA) Consortium
Contributions
Conceived of and designed the experiments: C.A.H. and F.J.C. Performed the experiments and analyzed the data: C.A.H., L.C.P., D.V.D.B., X.S., G.K.C., A. Holbrook, P.W., F.C., D.O.S., X.W., T.L., C.O., K.N.S., A.M.L., L.Y.X., S.L.S. and C.M.V. Contributed reagents, materials, analysis tools or comments on the manuscript: C.A.H., C.M.V., A.D., R.C.M., X.W., F.A., S.A., C.B.A., L. Baglietto, R.B., E.V.B., M.W.B., C.D.B., L. Bernstein, C.B., W.J.B., H.B., J.E.B., L.A.C., J.E.C., J.C.-C., S.J.C., D.I.C., C.L.C., A.C., S.S.C., S.L.D., R.B.D., A.M.D., W.R.D., T.D., L.D., D.E., C.K.E., A.B.E., P.A.F., H.S.F., D.F.-J., F.F., A.F., G.F., S.M.G., G.G.G., A.K.G., P.G., N.G., D.G., U.H., S.E.H., A. Hartmann, R.H., J.H., R.N.H., J.J.H., D.J.H., S.A.I., A.I., J.I., E.M.J., N.J., A.J.-V., R.K., Y.-D.K., L.N.K., I.K., V.-M.K., S.K., D.L., A.M.L., L.L.M., T.L., J.L., S.L., A.M., S.M., N.G.M., P.M., G.W.M., H.N., S. Nickels, S. Nyante, C.O., J. Palmer, H.P., D.P., C.M.P., J. Peto, P.D.P.P., L.C.P., M.F.P., K.P., T.R.R., J.L.R.-G., L.R., E.R., T.R., I.d.S.S., E.S., M.K.S., R.S.-W., F.S., G.S., X.S., L.B.S., H.-P.S., K.N.S., M.C.S., W.J.T., I.T., F.B.L.H., E.W., J.W., H.W., R.W., D.Y., W.Z., R.G.Z., A.S., S.L.S., D.O.S., D.E., P.K., B.E.H. and F.J.C. Wrote the paper: C.A.H. and F.J.C.
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Correspondence toChristopher A Haiman or Fergus J Couch.
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The authors declare no competing financial interests.
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A full list of members is provided in the Supplementary Note.
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Haiman, C., Chen, G., Vachon, C. et al. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer.Nat Genet 43, 1210–1214 (2011). https://doi.org/10.1038/ng.985
- Received: 03 May 2011
- Accepted: 28 September 2011
- Published: 30 October 2011
- Issue Date: December 2011
- DOI: https://doi.org/10.1038/ng.985