The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice (original) (raw)

• Selkoe, D.J. Normal and abnormal biology of the beta-amyloid precursor protein. A. Rev. Neurosci. 17, 489–517 (1994).
  Article CAS Google Scholar
• Price, D.L., Borchelt, D.R. & Sisodia, S.S. Alzheimer disease and the prion disorders amyloid β-protein and prion protein amyloidoses. Proc. natn. Acad. Sci. U.S.A. 90, 6381–6384 (1993).
  Article CAS Google Scholar
• Glenner, G.G. & Wong, C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. biophys. Res. Commun. 120, 885–890 (1984).
  Article CAS Google Scholar
• Masters, C.L. et al. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. natn. Acad. Sci. U.S.A. 82, 4245–4249 (1985).
  Article CAS Google Scholar
• Kang, J. et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733–736 (1987).
  Article CAS Google Scholar
• Ponte, P. et al. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 331, 525–527 (1988).
  Article CAS Google Scholar
• Tanzi, R.E. et al. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature 331, 528–530 (1988).
  Article CAS Google Scholar
• Haass, C. et al. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359, 322–325 (1992).
  Article CAS Google Scholar
• Shoji, M. et al. Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science 258, 126–129 (1992).
  Article CAS Google Scholar
• Busciglio, J., Gabuzda, D.H., Matsudaira, P. & Yankner, B.A. Generation of β-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc. natn. Acad. Sci. U.S.A. 90, 2092–2096 (1993).
  Article CAS Google Scholar
• Seubert, P. et al. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature 359, 325–327 (1992).
  Article CAS Google Scholar
• Citron, M. et al. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 360, 672–674 (1992).
  Article CAS Google Scholar
• Cai, X.-D., Golde, T.E. & Younkin, S.G. Release of excess amyloid β protein from a mutant amyloid β protein precursor. Science 259, 514–516 (1993).
  Article CAS Google Scholar
• Cotman, C.W., Pike, C.J. & Copani, A. β-amyloid neurotoxicity: a discussion of in vitro findings. Neurobiol. Aging 13, 587–590 (1992).
  Article CAS Google Scholar
• Price, D.L., Borocheit, D.R., Walker, L.C. & Sisodia, S.S. Toxicity of synthetic Aβ peptides and modeling of Alzheimer's disease. Neurobiol. Aging 13, 623–625 (1992).
  Article CAS Google Scholar
• Wirak, D.O. et al. Deposits of amyloid β protein in the central nervous system of transgenic mice. Science 253, 323–325 (1991).
  Article CAS Google Scholar
• Jucker, M. et al. Age-associated inclusions in normal and transgenic mouse brain. Science 255, 1443–1445 (1992).
  Article CAS Google Scholar
• Wirak, D.O. et al. Age-associated inclusions in normal and transgenic mouse brain. Science 255, 1445 (1992).
  Article CAS Google Scholar
• Kawabata, S., Higgins, G.A. & Gordon, J.W. Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein. Nature 354, 476–478 (1991).
  Article CAS Google Scholar
• Sandhu, F.A., Salim, M. & Zain, S.B. Expression of the human β-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice. J. biol. Chem. 266, 21331–21334 (1991).
  CAS PubMed Google Scholar
• Kawabata, S., Higgins, G.A. & Gordon, J.W. Alzheimer's retraction. Nature 356, 23 (1992).
  Article CAS Google Scholar
• Kammesheidt, A. et al. Deposition of β/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc. natn. Acad. Sci. U.S.A. 89, 10857–10861 (1992).
  Article CAS Google Scholar
• Quon, D. et al. Formation of β-amyloid protein deposits in brains of transgenic mice. Nature 352, 239–241 (1991).
  Article CAS Google Scholar
• Yamaguchi, F. et al. Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory. NeuroReport 2, 781–784 (1991).
  Article CAS Google Scholar
• Lamb, B.T. et al. Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice. Nature Genet. 5, 22–30 (1993).
  Article CAS Google Scholar
• Pearson, B. & Choi, T. Expression of the human β-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice. Proc. natn. Acad. Sci. U.S.A. 90, 10578–10582 (1993).
  Article CAS Google Scholar
• Wertkin, A.M. et al. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular β-amyloid or A4 peptides. Proc. natn. Acad. Sci. U.S.A. 90, 9513–9517 (1993).
  Article CAS Google Scholar
• Grundke-Iqbal, I. et al. Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease. Proc. natn. Acad. Sci. U.S.A. 86, 2853–2857 (1989).
  Article CAS Google Scholar
• Perry, G., Cras, P., Siedlak, S.L., Tabaton, M. & Kawai, M. β protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease. Am. J. Path. 140, 283–290 (1992).
  CAS PubMed Google Scholar
• Murphy, G.M. et al. Development of a monoclonal antibody specific for the COOH-terminal of β-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders. Am. J. Path. 144, 1082–1088 (1994).
  CAS PubMed Google Scholar
• Maruyama, K., Terakado, K., Usami, M. & Yoshikawa, K. Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor. Nature 347, 566–569 (1990).
  Article CAS Google Scholar
• Hayashi, Y., Kashiwagi, K. & Yoshikawa, K. Protease inhibitors generate cytotoxic fragments from Alzheimer amyloid protein precursor in cDNA-transfected glioma cells. Biochem. Biophys. Res. Commun. 187, 1249–1255 (1992).
  Article CAS Google Scholar
• Yoshikawa, K., Aizawa, T. & Hayashi, Y. Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359, 64–67 (1992).
  Article CAS Google Scholar
• Hilbich, C., Kisters-Woike, B., Reed, J., Masters, C.L. & Beyreuther, K. Human and rodent sequence analogs of Alzheimer's amyloid βA4 share similar properties and can be solubilized in buffers of pH 7.4. Eur. J. Biochem. 201, 61–69 (1991).
  Article CAS Google Scholar
• Fraser, P.E. et al. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer Amyloid β-protein. Biochemistry 31, 10716–10723 (1992).
  Article CAS Google Scholar
• Julien, J.-P., Meyer, D., Flavell, D., Hurst, J. & Grosveld, F. Cloning and developmental expression of the murine neurofilament gene family. Molec. Brain Res. 1, 243–250 (1986).
  Article CAS Google Scholar
• Hinrichs, S.H., Nerenberg, M., Reynolds, R.K., Khoury, G. & Jay, G. A transgenic mouse model for human neurofibromatosis. Science 237, 1340–1343 (1987).
  Article CAS Google Scholar
• Vogel, J., Hinrichs, S.H., Reynolds, R.K., Luciw, P.A. & Jay, G. The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice. Nature 335, 606–611 (1988).
  Article CAS Google Scholar
• Green, J.E., Hinrichs, S.H., Vogel, J. & Jay, G. Exocrinopathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice. Nature 341, 72–74 (1989).
  Article CAS Google Scholar
• Kim, C.-M., Koike, K., Saito, I., Miyamura, T. & Jay, G. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351, 317–320 (1991).
  Article CAS Google Scholar
• CDC. Mortality from Alzheimer disease-United States, 1979–1987. MMWR Morb. Mortal. Wkty. Rep. 39, 785–788 (1990).
• Farlow, M. et al. Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G→T change at position 2149 of the amyloid precursor protein gene. Neurology 44, 105–111 (1994).
  Article CAS Google Scholar
• Risse, S.C. et al. Myoclonus, seizures, and paratonia in Alzheimer disease. Alzheimer Dis. Assoc. Disord. 4, 217–225 (1990).
  Article CAS Google Scholar
• Romanelli, M.F., Morris, J.C., Ashkin, K. & Coben, L.A., Advanced Alzheimer's disease is a risk factor for late-onset seizures. Arch. Neurol. 47, 847–850 (1990).
  Article CAS Google Scholar
• Hauser, W.A., Morris, M.L., Heston, L.L. & Anderson, V.E. Seizures and myoclonus in patients with Alzheimer's disease. Neurology 36, 1226–1230 (1986).
  Article CAS Google Scholar
• Begemann, M., Tan, S.-S., Cunningham, B.A. & Edelman, G.M. Expression of chicken liver cell adhesion molecule fusion genes in transgenic mice. Proc. natn. Acad. Sci. U.S.A. 87, 9042–9046 (1990).
  Article CAS Google Scholar
• Wyllie, A.H. Cell death. Int. Rev. Cytol. S17, 755–785 (1987).
  Google Scholar
• Gavrieli, Y., Sherman, Y. & Ben-Sasson, S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation J. Cell Biol. 119, 493–501 (1992).
  Article CAS Google Scholar
• Cohen, J.J. Apoptosis. Immunol. Today 14, 126–130 (1993).
  Article CAS Google Scholar
• Duffy, P., Mayeuz, R. & Kupsky, W., Famillal Alzheimer's disease with myoclonus and ‘spongy change’. Arch. Neurol. 45, 1097–1100 (1988).
  Article CAS Google Scholar
• Carson, D.A. & Ribeiro, J.M. Apoptosis and disease. Lancet 341, 1251–1254 (1993).
  Article CAS Google Scholar
• Loo, D.T. et al. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. natn. Acad. Sci. U.S.A. 90, 7951–7955 (1993).
  Article CAS Google Scholar
• Norton, W.T., Aquino, D.A., Hozumi, I., Chiu, F.-C. & Brosnan, C.F. Quantitative aspects of reactive gliosis: a review. Neurochem. Res. 17, 877–885 (1992).
  Article CAS Google Scholar
• Delacourte, A. General and dramatic glial reaction in Alzheimer brains. Neurology 40, 33–37 (1990).
  Article CAS Google Scholar
• Vijayan, V.K. et al. Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation. Exp. Neurol. 112, 72–78 (1991).
  Article CAS Google Scholar
• Frederickson, R.C.A. Astroglia in Alzheimer's disease. Neurobiol. Aging 13, 239–253 (1992).
  Article CAS Google Scholar
• Eng, L.F. Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes. J. Neuroimmunol. 8, 203–214 (1985).
  Article CAS Google Scholar
• Mucke, L., Oldstone, M.B.A., Morris, J.C. & Nerenberg, M.I. Rapid activation of astrocyte-specific expression of GFAP-lacZ transgene by focal injury. New Biol. 3, 465–474 (1991).
  CAS Google Scholar
• Mandybur, T.I. & Chuirazzi, C.C. Astrocytes and the plaques of Alzheimer's disease. Neurology 40, 635–639 (1990).
  Article CAS Google Scholar
• Joachim, C.L., Mori, H. & Selkoe, D.J. Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease. Nature 341, 226–230 (1989).
  Article CAS Google Scholar
• Byrne, G.W. & Ruddle, F.H. Multiplex gene regulation: A two-tiered approach to transgene regulation in transgenic mice. Proc. natn. Acad. Sci. U. S. A 86, 5473–5477 (1989).
  Article CAS Google Scholar
• Julien, J.-P., Beaudet, L., Tretjakoff, I. & Peterson, A. Neurofilament gene expression in transgenic mice. J. Physiol. (Paris) 84, 50–52 (1992).
  Google Scholar
• Monteiro, M.J., Hoffman, P.J., Gearhart, J.D. & Cleveland, D.W. Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J. Cell Biol. 111, 1543–1557 (1990).
  Article CAS Google Scholar
• Pollock, R.A., Jay, G. & Bieberich, C.J. Altering the boundaries of Hox3.1 expression: evidence for antipodal gene expression. Cell 71, 911–923 (1992).
  Article CAS Google Scholar
• Selkoe, D.J. et al. Beta-amyloid precursor protein of Alzheimer disease occurs as 110-to 135 kilodalton membrane-associated proteins in neural and nonneural tissues. Proc. natn. Acad. Sci. U.S.A. 85, 7341–7345 (1988).
  Article CAS Google Scholar
• Kim, K.S. et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Comm. 2, 121–130 (1988).
  CAS Google Scholar
• Kozak, M. Bifunctional messenger RNAs in eukaryotes. Cell 44, 283–292 (1986).
  Article CAS Google Scholar
• Carswell, S. & Alwine, J.C. Efficiency of utilization of the simian virus 40 late polyadenylatlon site: effects of upstream sequences. Molec. cell. Biol. 9, 4248–4258 (1989).
  Article CAS Google Scholar
• Monteiro, M.J. & Cleveland, D.W. Expression of NF-L and NF-M in f ibroblasts reveals coassembly of neurofilament and vimentin subunits. J. Cell Biol. 108, 579–593 (1990).
  Article Google Scholar