Functional inactivation but not structural mutation of p53 causes liver cancer (original) (raw)

References

  1. Harris, C.C. & Hollstein, M. Clinical implications of the p53 tumor-suppressor gene. New Engl. J. Med. 329, 1318–1327 (1993).
    Article CAS PubMed Google Scholar
  2. Jay, G. et al. A common transformation-related protein in murine sarcomas and leukemias. Cold Spring Harbor Symp. Quant. Biol. 44, 659–664 (1979).
    Article Google Scholar
  3. DeLeo, A.B. et al. Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc. natn. Acad. Sci. U.S.A. 76, 2420–2424 (1979).
    Article CAS Google Scholar
  4. Lane, D.P. & Crawford, L.V. T Antigen is bound to a host protein in SV40-transformed cells. Nature 278, 261–263 (1979).
    Article CAS PubMed Google Scholar
  5. Linzer, D.I. & Levine, A.J. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17, 43–52 (1979).
    Article CAS PubMed Google Scholar
  6. Dippold, W.G., Jay, G., DeLeo, A.B., Khoury, G. & Old, L.J. p53transformation-related protein: Detection by monoclonal antibody in mouse and human cells. Proc. natn. Acad. Sci. U.S.A. 78, 1695–1699 (1981).
    Article CAS Google Scholar
  7. Crawford, L.V., Pim, D.C., Gurney, E.G., Goodfellow, P. & Taylor-Papadimitriou, J. Detection of a common feature in several human tumor cell lines — a 53,000-dalton protein. Proc. natn. Acad. Sci. U.S.A. 78, 41–45 (1981).
    Article CAS Google Scholar
  8. Sarnow, P., Ho, Y.S., Williams, J. & Levine, A.J., Adenovirus E1b-58 kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells. Cell 28, 387–394 (1982).
    Article CAS PubMed Google Scholar
  9. Szekely, L., Selivanova, G., Magnusson, K.P., Klein, G. & Wiman, K.G. EBNA-5, an Epstein-Barrvirus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins. Proc. natn. Acad. Sci. U.S.A. 90, 5455–5459 (1993).
    Article CAS Google Scholar
  10. Werness, B.A., Levine, A.J. & Howley, P.M. Association of human papillomavlrus types 16 and 18 E6 proteins with p53. Science 248, 76–79 (1990).
    Article CAS PubMed Google Scholar
  11. Feitelson, M.A., Zhu, M., Duan, L.X. & London, W.T. Hepatitis Bx antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma. Oncogene 8, 1109–1117 (1993).
    CAS PubMed Google Scholar
  12. Levine, A.J., Momand, J. & Findlay, C.A. The p53 tumour suppressor gene. Nature 351, 453–456 (1991).
    Article CAS PubMed Google Scholar
  13. Momand, J., Zambetti, G.P., Olson, D., George, D.L. & Levine, A.J. The mdm-2 oncogene product forms a complex with the p53 protein and Inhibits p53-mediated transactivation. Cell 69, 1237–1245 (1992).
    Article CAS PubMed Google Scholar
  14. Barak, Y. & Oren, M. Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest. EMBO J. 11, 2115–2121 (1992).
    Article CAS PubMed PubMed Central Google Scholar
  15. Pietenpol, J.A. & Vogelstein, B. Tumour suppressor genes: no room at the p53 inn. Nature 365, 17–18 (1993).
    Article CAS PubMed Google Scholar
  16. Beasley, R.P. & Hwang, L.Y. in Viral hepatitis and liver disease. (eds Vyas, G.N.,Dienstag. J.L. & Hoofnagle, J.H.) 209–224 (Grune & Stratton, NewYork, 1984).
    Google Scholar
  17. Tiollais, P., Pourcel, C. & Dejean, A. The hepatitis B virus. Nature 317, 489–495 (1985).
    Article CAS PubMed Google Scholar
  18. Popper, H., Shafritz, D.A. & Hoofnagle, J.H. Relation of the hepatitis B virus carrier state to hepatocellular carcinoma. Hepatology 7, 764–772 (1987).
    Article CAS PubMed Google Scholar
  19. Hsu, I.C., Metcalf, R.A., Sun, T., Welsh, J.A., Wang, N.J. & Harris, C.C. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 350, 427–428 (1991).
    Article CAS PubMed Google Scholar
  20. Bressac, B., Kew, M.C., Wand, J.R. & Ozturk, M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 350, 429–431 (1991).
    Article CAS PubMed Google Scholar
  21. Hosono, S., Lee, C.-S., Chou, M.-J., Yang, C.-S. & Shin, C. Molecular analysis of the p53 alleles In primary hepatocellular carcinomas and cell lines. Oncogene 6, 237–243 (1991).
    CAS PubMed Google Scholar
  22. Buetow, K.H., Sheffield, V.C., Zhu, M., Zhou, T., Shen, M.F. & Hino, O. Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas. Proc. natn. Acad. Sci. U.S.A. 89, 9622–9626 (1992).
    Article CAS Google Scholar
  23. Sheu, J.C., Huang, G.T., Lee, P.H., Chung, J.C., Chou, H.C. & Lai, M.Y. Mutation of p53 gene in hepatocellular carcinoma in Taiwan. Cancer Res. 52, 6098–6100 (1992).
    CAS PubMed Google Scholar
  24. Nishida, N., Fukuda, Y., Kokuryu, H., Toguchida, J., Yandell, D.W. & Ikenega, M. Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma. Cancer Res. 53, 368–372 (1993).
  25. Unsal, H., Yakicier, C., Marcais, C., Kew, M., Volkmann, M. & Zentgraf, H. Genetic heterogeneity of hepatocellular carcinoma. Proc. natn. Acad. Sci. U.S.A. 91, 822–826 (1994).
    Article CAS Google Scholar
  26. Twu, J.S. & Schloemer, R.H. Transcriptional trans-activating function of hepatitis B virus. J. Virol. 61, 3448–3453 (1987).
    CAS PubMed PubMed Central Google Scholar
  27. Seto, E., Yen, T., Peterlin, B.M. & Ou, J. Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc. natn. Acad. Sci. U.S.A. 85, 8286–8290 (1988).
    Article CAS Google Scholar
  28. Spandau, D.F. & Lee, C.H. Trans-activation of viral enhancers by the hepatitis B virus X protein. J. Virol. 62, 427–434 (1988).
    CAS PubMed PubMed Central Google Scholar
  29. Colgrove, R., Simon, G. & Ganem, D. Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication. J. Virol. 63, 4019–4026 (1989).
    CAS PubMed PubMed Central Google Scholar
  30. Kim, C.-M., Koike, K., Saito, I., Miyamura, T. & Jay, G., The HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351, 317–320 (1991).
    Article CAS PubMed Google Scholar
  31. Lee, T.-H., Finegold, M.J., Shen, R.F., DeMayo, J.L., Woo, S.L.C. & Butel, J.S. Hepatitis B virus transact!vator X protein is not tumorigenic In transgenic mice. J. Virol. 64, 5939–5947 (1990).
    CAS PubMed PubMed Central Google Scholar
  32. Feitelson, M.A. & Clayton, M.M. X antigen polypeptides in the sera of hepatitis B virus-infected patients. Virology 177, 367–371 (1990).
    Article CAS PubMed Google Scholar
  33. Kekule, A.S., Lauer, U., Weiss, L., Luber, B. & Hofschneider, P.H. Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 361, 742–745 (1993).
    Article CAS PubMed Google Scholar
  34. Cross, J.C., Wen, P. & Rutter, W.J. Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/ threonine kinases. Proc. natn. Acad. Sci. U.S.A. 90, 8078–8082 (1993).
    Article CAS Google Scholar
  35. Ullrich, S.J. et al. Phosphorylation at Ser-15 and Ser-392 In mutant p53 molecules from human tumors is altered compared to wild-type p53. Proc. natn. Acad. Sci. U.S.A. 90, 5954–5958 (1993).
    Article CAS Google Scholar
  36. Harlow, E., Crawford, L.V., Pirn, D.C. & Williamson, N.A. Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol. 39, 861–869 (1981).
    CAS PubMed PubMed Central Google Scholar
  37. Hsu, H.-C., Tseng, H.-J., Lai, P.-L., Lee, P.-H. & Peng, S.-Y. Expression of p53 gene In 184 unlfocal hepatocellular carcinomas: association with tumor growth and invasiveness. Cancer Res. 53, 4691–4694 (1993).
    CAS PubMed Google Scholar
  38. Schek, N., Bartenschlager, R., Kuhn, C. & Schaller, H. Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virus. Oncogene 6, 1735–1744 (1991).
    CAS PubMed Google Scholar
  39. Jay, G., Khoury, G., DeLeo, A.B., Dippold, W.G. & Old, L.J. p53transformation-related protein: Detection of an associated phosphotransferase activity. Proc. natn. Acad. Sci. U.S.A. 78, 2931–2936 (1981).
    Google Scholar
  40. Ullrich, S.J., Anderson, C.W., Mercer, W.E. & Appella, E. The p53 tumor suppressor protein, a modulator of cell proliferation. J. biol. Chem. 267, 15259–15262 (1992).
    CAS PubMed Google Scholar
  41. Wang, X.W., Forrester, K., Yeh, H., Feitelson, M.A., Gu, J.-R. & Harris, C.C. Hepatitis B virus X protein Inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc. natn. Acad. Sci. U.S.A 91, 2230–2234 (1994).
    Article CAS Google Scholar
  42. Tur-Kaspa, R. et al. Alpha Interferon suppresses hepatitis B virus enhancer activity and reduces viral gene transcription. J. Virol. 64, 1821–1824 (1990).
    CAS PubMed PubMed Central Google Scholar
  43. Horisberger, M.A. & DeStaritzky, K. A recombinant human interferon-alpha B/D hybrid with a broad host-range. J. gen. Virol. 68, 945–948 (1987).
    Article CAS PubMed Google Scholar
  44. Gangemi, J.D., Lazdins, J., Dietrich, F.M., Matter, A., Poncioni, B. & Hochkeppel, H.-K. Antiviral activity of anovel recombinant human interferon-alpha B/D hybrid. J. Interferon Res. 9, 227–237 (1989).
    Article CAS PubMed Google Scholar
  45. Perrillo, R.P. Interferon in the management of chronic hepatitis B. Dig. Dis. Sci. 38, 577–593 (1993).
    Article CAS PubMed Google Scholar
  46. Orita, M., Suzuki, Y., Sekiya, T. & Hayashi, K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5, 874–879 (1989).
    Article CAS PubMed Google Scholar
  47. Tanaka, S., Toh, Y., Adachi, E., Matsumato, T., Mori, R. & Sujimachi, K. Tumor progression in hepatocellular carcinoma may be mediated by p53 mutation. Cancer Res. 53, 2884–2887 (1993).
    CAS PubMed Google Scholar
  48. Oda, T., Tsuda, H., Scarpa, A., Sakamoto, M. & Hirohashi, S. p53 gene mutation spectrum in hepatocellular carcinoma. Cancer Res. 52, 6358–6364 (1992).
    CAS PubMed Google Scholar
  49. Teramoto, T., Satonaka, K., Kitazawa, S., Fujimori, T., Kozaburo, H. & Maeda, S. . p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis. Cancer Res. 54, 231–235 (1994).
    CAS PubMed Google Scholar
  50. Greenblatt, M.S., Bennett, W.P., Hollstein, M. & Harris, C.C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesls. Cancer Res. 54, 4855–4878 (1994).
    CAS PubMed Google Scholar
  51. Halevy, O., Rodel, J., Peled, A. & Oren, M. Frequent p53 mutations in chemically induced murine fibrosarcoma. Oncogene 6, 1593–1600 (1991).
    CAS PubMed Google Scholar
  52. Fujiyama, A., Miyanohara, A., Nozaki, C., Yoneyama, T., Ohtomo, N. & Matsubara, K. Cloning and structural analyses of hepatitis B virus DNAs, subtype adr. Nucl. Acids Res. 11, 4601–4610 (1983).
    Article CAS PubMed PubMed Central Google Scholar
  53. Gutierrez, M.I. et al. Infrequent p53 mutation In mouse tumors with deregulated myc. Cancer Res. 52, 1032–1035 (1992).
    CAS PubMed Google Scholar

Download references