Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia (original) (raw)

References

  1. Rabbitts, T.H. Chromosomal translocations in human cancer. Nature. 372, 143–149 (1994).
    Article CAS PubMed Google Scholar
  2. Sandberg, A.A. The chromosomes in human cancer and leukemia 2nd edn. (Elsevier, New York, 1990).
    Google Scholar
  3. Morris, C.M. et al. HRAS1 and INS genes are relocated but not structurally altered as a result of the t(7;11)(p15;p15) in a clone from a patient with acute myeloid leukaemia (M4). Br. J. Haemat. 71, 481–86 (1989).
    Article CAS Google Scholar
  4. Nakamura, T., Largaespada, D.A., Shaughnessy, Jr., J.D., Jenkins, N.A. & Copeland, N.G. Cooperative activation of Hoxa and Pbx1 -related genes in murine myeloid leukemias. Nature Genet. 12, 149–153 (1996).
    Article CAS PubMed Google Scholar
  5. Acampora, D. et al. The human HOX gene family. Nucl. Acids Res. 17, 10385–10402 (1989).
    Article CAS PubMed PubMed Central Google Scholar
  6. Iris, F.J.M. et al. Dense Alu clustering and a potential new member of the NFKB family within a 90 kilobase HLA Class III segment. Nature Genet. 3, 137–145 (1993).
    Article CAS PubMed Google Scholar
  7. Radu, A., Moore, M.S. & Blobel, G. The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell. 81, 215–222 (1995).
    Article CAS PubMed Google Scholar
  8. Benson, G.V., Nguyen, T-H.E. & Maas, R.L. The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of abdominal B-like genes. Mol. Cell. Biol. 15, 1591–1601 (1995).
    Article CAS PubMed PubMed Central Google Scholar
  9. Rubin, M.R. et al. Murine Hox-1.7 homeobox gne: Cloning, chromosomal location, and expression. Mol. Cell. Biol. 7, 3836–3841 (1987).
    Article CAS PubMed PubMed Central Google Scholar
  10. Silver, P A How proteins enter the nucleus. Cell 64, 489–497 (1991).
    Article CAS PubMed Google Scholar
  11. Burd, C.G. & Dreyfuss, G. Conserved structures and diversity of functions of RNA-binding proteins. Science 154, 1662–1665 (1994).
    Google Scholar
  12. Fabre, E., Boelens, W.C., Wimmer, C., Mattaj, I.W. & Hurt, E.G. Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif. Cell 78, 275–289 (1994).
    Article CAS PubMed Google Scholar
  13. Barker, D., Holm, T. & White, R. A locus on chromosome 11 p with multiple restriction site polymorphisms. Am. J. Hum. Genet. 36, 1159–1171 (1984).
    CAS PubMed PubMed Central Google Scholar
  14. Koi, M. et al. Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11. Science. 260, 361–364 (1993).
    Article CAS PubMed Google Scholar
  15. Tanigami, A. et al. Mapping of 262 DNA markers into 24 intervals on human chromosome 11. Am. J. Hum. Genet. 50, 56–64 (1992).
    CAS PubMed PubMed Central Google Scholar
  16. von Lindern, M. et al. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. Mol. Cell. Biol. 12, 1687–1697 (1992).
    Article CAS PubMed PubMed Central Google Scholar
  17. Kraemer, D., Wozniak, R.W., Blobel, G. & Radu, A. The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. Proc. Natl. Acad. Sci. USA 91, 1519–1523 (1994).
    Article CAS PubMed PubMed Central Google Scholar
  18. Fornerod, M. et al. Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements. Oncogene 10, 1739–1748 (1995).
    CAS PubMed Google Scholar
  19. von Lindern, M. et al. can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′ half to different genes: Characterization of the set gene. Mol. Cell. Biol. 12, 3346–3355 (1992).
    Article CAS PubMed PubMed Central Google Scholar
  20. Adachi, Y, Pavlakis, G. N. & Copeland, T.D. Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia. J. Biol. Chem. 269, 2258–2262 (1994).
    CAS PubMed Google Scholar
  21. Ishimi, I. & Kikuchi, A. Identification and molecular cloning of a yeast homolog of nucleosome assembly protein I which facilitates nucleosome assembly in vitro. J. Biol. Chem. 266, 7025–7029 (1991).
    CAS PubMed Google Scholar
  22. Kwong, Y.L. & Chan, T.K. Translocation (7;11)(p15;p15) in acute myeloid leukemia M2: Association with trilineage myelodysplasia and giant dysplastic myeloid cells. Am. J. Hemat. 47, 62–64 (1994).
    Article CAS PubMed Google Scholar
  23. Hoovers, J.M.N. et al. Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments. Proc. Natl. Acad. Sci. USA(in the press).
  24. Winqvist, R. et al. Loss of heterozygosity for chromosome 11 in primary human breast tumors is associated with poor survival after metastasis. Cancer Res. 55, 2660–2664 (1995).
    CAS PubMed Google Scholar
  25. Bepler, G. & Garcia-Blanco, M.A. Three tumor-suppressor regions on chromosome 11p identified by high-resolution deletion mapping in human non-small-cell lung cancer. Proc. Natl. Acad. Sci. USA. 91, 5513–5517 (1994).
    Article CAS PubMed PubMed Central Google Scholar
  26. Chan, S-K., Jaffe, L, Capovilla, M., Botas, J. & Mann, R.S. The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell 78, 603–615 (1994).
    Article CAS PubMed Google Scholar
  27. van Dijk, M.A. & Mure, C. extradenticle raises the DNA binding specificity of homeotic selector gene products. Cell 78, 617–624 (1994).
    Article CAS PubMed Google Scholar
  28. Shimamoto, T. et al. Late appearance of a Philadelphia translocation with minor-BCR/ABL transcript in a t(7;11)(p15;p15) acute myeloid leukemia. Leukemia. 9, 640–642 (1995).
    CAS PubMed Google Scholar
  29. Fujimura, T. et al. Two additional cases of acute myeloid leukemia with t(7;11)(p15;p15) having low neutophil alkaline phosphatase scores. Cancer Genet Cytogenet. 68, 143–146 (1993).
    Article CAS PubMed Google Scholar
  30. Sambrook, J., Fritsch, E.P. & Maniatis, T., Cloning: a Laboratory Manual. 2nd edn (Cold Spring Harbor, Laboratory Press, NewYork, 1989).
    Google Scholar
  31. Jenkins, N.A., Copeland, N.G., Taylor, B.A., Bedigian, H.G. & Lee, B.K. Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice. J. Virol. 42, 379–388 (1982).
    CAS PubMed PubMed Central Google Scholar
  32. Glaser, T, Housman, D.E., Lewis, W.H., Gerhard, D .& Jones, C. A fine-structure deletion map of human chromosome 11 p; analysis of J1 series hybrids. Som. Cell Mol. Genet. 15, 477–501 (1989).
    Article CAS Google Scholar
  33. Redeker, E. et al. An integrated physical map of 210 markers assigned to the short arm of human chromosome 11. Genomics. 21, 538–550 (1994).
    Article CAS PubMed Google Scholar
  34. Devereux, J., Haeberli, P. & Smithies, O. A comprhensive set of sequence analysis programs for the VAX.Nucl. Acids Res. 12, 387–395 (1984).
    Article CAS PubMed PubMed Central Google Scholar
  35. Gish, W. & States, D.J. Identification of protein coding regions by database similarity search. Nature Genet. 3, 266–272 (1993).
    Article CAS PubMed Google Scholar

Download references