The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice (original) (raw)
References
Hustad, C.M. et al. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics140, 255–265 (1995). CASPubMedPubMed Central Google Scholar
Church, D.M. et al. Isolation of genes from complex sources of mammalian genomic DNA using exon amplification. Nature Genet.6, 98–105 (1994). ArticleCASPubMed Google Scholar
Scheffner, M., Nuber, U. & Huibregtse, J.M. Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature375, 81–83 (1995). Article Google Scholar
Kozak, M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Adds Res.15, 8125–8148 (1987). ArticleCAS Google Scholar
Huibregtse, J.M., Scheffner, M. & Howley, P.M. Cloning and expression of the cDNA for E6-Ap, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol. Cell. Biol.13, 775–784 (1993). ArticleCASPubMedPubMed Central Google Scholar
Huibregtse, J.M., Scheffner, M., Beaudenon, S. & Howley, P.M. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natal. Acad. Sci. USA92, 2563–2567 (1995). ArticleCAS Google Scholar
Sudol, M. The WW module competes with the SH3 domain? Trends Biochem. Sci.21, 161–163 (1996). ArticleCASPubMed Google Scholar
Daveltov, B.A. & Sudhof, T.C. A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. J. Biol. Chem.268, 26386–26390 (1993). Google Scholar
Vrieling, H.D., Duhl, M.J., Millar, S.E., Miller, K.A. & Barsh, G.S. Differences in dorsal and ventral pigmentation results from regional expression of the mouse agouti gene. Proc. Natal. Acad. Sci. USA91, 170–178 (1994). Article Google Scholar
Green, M.C. & Schultz, L.D., Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J. Hered.66, 250–258 (1975). ArticleCASPubMed Google Scholar
Sidman, C.L., Shultz, L.D. & Unanue, E.R. The mouse mutant “motheaten.” I. Development of lymphocyte populations. J. Immunol.121, 2392–2398 (1978). CASPubMed Google Scholar
Shultz, L.D. et al. Mutations at the murine motheaten locus are within the haematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell73, 1445–1454 (1993). ArticleCASPubMed Google Scholar
Tsui, H.W., Siminovitch, K.A., De Souza, L., & Tsui, F.W.L. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nature Genet.4, 124–129 (1993). ArticleCASPubMed Google Scholar
Jiao, H. et al. Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: Detection of potential HCP substrates in GM-CSF signal transduction. Exp. Haematol.25, 592–600 (1997). CAS Google Scholar
Piao, X., Paulson, R., van der Geer, P., Pawson, T. & Bernstein, A. Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Proc. Natal. Acad. Sci. USA93, 14665–14669 (1996). ArticleCAS Google Scholar
David, M., Chen, H.E., Goelz, S., Larner, A.C. & Neel, B.G. Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol. Cell. Biol.15, 7050–7058 (1995). ArticleCASPubMedPubMed Central Google Scholar
Lee, F.S., Hagler, J., Chen, Z.J. & Maniatis, T. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell88, 213–222 (1997). ArticleCASPubMed Google Scholar
Miyazawa, K. et al. Ligand-dependent polyubiquitination of c-fc/tgene product: a possible mechanism of receptor down modulation in M107e cells. Blood83, 137–145 (1994). CASPubMed Google Scholar
Mori, S., Heldin, C.-H. & Claesson-Welsh, L. Ligand-induced polyubiquitination of the platelet-derived growth factor (3-receptor plays a negative regulatory role in its mitogenic signaling. J. Biol. Chem.268, 577–583 (1992). Google Scholar
Mori, S., Claesson-Welsh, L., Okuyama, Y. & Saito, Y. Ligand-induced polyubiquitination of receptor tyrosine kinases. Biochem. Biophys. Rec. Comm.213, 32–39 (1995). ArticleCAS Google Scholar
Mori, S., Tanaka, K., Omura, S. & Saito, Y. Degradation process of ligand-stimulated platelet-derived growth factor receptor involves ubiquitin-proteasome proteolytic pathway. J. Biol. Chem.270, 29447–29452 (1995). ArticleCASPubMed Google Scholar
Cattanach, B.M., Lyon, M.F., Peters, J. & Searle, A.G. Agouti locus mutations at Harwell. Mouse News Lett.77, 123–125 (1987). Google Scholar
Gish, W. & States, D.J. Identification of protein coding regions by database similarity search. Nature Genet.3, 266–272 (1993). ArticleCASPubMed Google Scholar
Perry, W.L., Hustad, C.M., Swing, D.A., Jenkins, N.A. & Copeland, N.G. A transgenic mouse assay for agouti protein activity. Genetics140, 267–274 (1995). CASPubMedPubMed Central Google Scholar