A breakpoint map of recurrent chromosomal rearrangements in human neoplasia (original) (raw)
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- Published: April 1997
Nature Genetics volume 15, pages 417–474 (1997)Cite this article
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Abstract
Cytogenetic studies over the past few decades have revealed clonal chromosomal aberrations in almost 27,000 human neoplasms. Many of these neoplasia-associated chromosomal abnormalities have been characterised at the molecular level, revealing previously unknown genes that are closely associated with the tumorigenic process. Information on chromosome changes in neoplasia is growing rapidly, making it difficult to identify all recurrent chromosomal aberrations. We have developed a computer program to ascertain, for the first time, all recurrent structural abnormalities in all haematological malignancies and solid tumours published up to June 19%. Out of 26,523 cases, a total of 215 balanced and 1,588 unbalanced recurrent aberrations were identified among 75 different neoplastic disorders. Our compilation of all recurrent balanced and unbalanced neoplasia-associated rearrangements should help in directing future efforts aimed at identifying the molecular mechanisms involved in tumorigenesis.
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Authors and Affiliations
- Department of Clinical Genetics, University Hospital, S-22185, Lund, Sweden
Felix Mitelman, Fredrik Mertens & Bertil Johansson
Authors
- Felix Mitelman
You can also search for this author inPubMed Google Scholar - Fredrik Mertens
You can also search for this author inPubMed Google Scholar - Bertil Johansson
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Mitelman, F., Mertens, F. & Johansson, B. A breakpoint map of recurrent chromosomal rearrangements in human neoplasia.Nat Genet 15 (Suppl 4), 417–474 (1997). https://doi.org/10.1038/ng0497supp-417
- Issue Date: April 1997
- DOI: https://doi.org/10.1038/ng0497supp-417
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