Walport, M.J. & Morgan, B.P. Complement deficiency and disease. Immunol. Today12, 301–306 (1991). Article Google Scholar
Lachmann, P.J. & Walport, M.J. Deficiency of the effector mechanisms of the immune response and autoimmunity. in Ciba Foundation Symposium: Autoimmunity and Autoimmune diseases (ed. Whelan, J.) 129, 149–171 (Wiley, Chichester, 1987). CAS Google Scholar
McAdam, R.A., Goundis, D. & Reid, K.M.B. A homozygous point mutation results in a stop codon in the C1q B-chain of a Clq-deficient individual. Immunogenetics27, 259–264 (1988). ArticleCAS Google Scholar
Bowness, P. et al. Hereditary C1q deficiency and systemic lupus erythematosus. Quart. J. Med.87, 455–464 (1994). CAS Google Scholar
Petry, F., Le, D.T., Kirschfink, M. & Loos, M. Nonsense and missense mutations in the structural genes of complement component C1q A and C chains are linked with two different types of complete selective C1q deficiencies. J. Immunol.155, 4734–4738 (1995). CASPubMed Google Scholar
Slingsby, J.H. et al. Homozygous hereditary C1q deficiency and systemic lupus erythematosus. A new family and the molecular basis of C1q deficiency in three families. Arthritis Rheum.39, 663–670 (1996). ArticleCAS Google Scholar
Topaloglu, R. et al. Molecular basis of hereditary C1q deficiency associated with SLE and IgA nephropathy in a Turkish family. Kidney Int.50, 635–642 (1996). ArticleCAS Google Scholar
Petry, F., Izzet Berkel, A. & Loos, M. Multiple identification of a particular type of hereditary C1q deficiency in the Turkish population: review of the cases andadditional genetic and functional analysis. Human Genet.100, 51–56 (1997). ArticleCAS Google Scholar
Petry, F. et al. The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organisation. Immunogenetics43, 370–376 (1996). CASPubMed Google Scholar
Jevnikar, A.M., Slinger, G.G., Brennan, D.C., Xu, H.W. & Kelley, V.R. Dexamethasone prevents autoimmune nephritis and reduces renal expression of la but not costimulatory signals. Am. J. Pathol.141, 743–751 (1992). CASPubMedPubMed Central Google Scholar
Baker, A.J. et al. Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. J. Clin. Invest.94, 2105–2116 (1994). ArticleCAS Google Scholar
Korb, L.C. & Ahearn, J.M. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes. Complement deficiency and systemic lupus erythematosus revisited. J. Immunol.158, 4525–4528 (1997). CASPubMed Google Scholar
LeFeber, W.P. et al. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J. Clin. Invest.74, 1545–1551 (1984). ArticleCAS Google Scholar
Golan, T.D., Elkon, K.B., Gharavi, A.E. & Krueger, J.G. Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation. J. Clin. Invest.90, 1067–1076 (1992). ArticleCAS Google Scholar
Casciola-Rosen, L.A., Anhalt, G. & Rosen, A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med.179, 1317–1330 (1994) ArticleCAS Google Scholar
Rosen, A., Casciola-Rosen, L.A. & Ahearn, J. Novel packages of viral and self-antigens are generated during apoptosis. J. Exp. Med.181, 1557–1561 (1995). ArticleCAS Google Scholar
Casciola-Rosen, L.A., Rosen, A., Petri, M. & Schlissel, M. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: Implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA93, 1624–1629 (1996). ArticleCAS Google Scholar
Trinder, P., Faust, D., Petry, F. & Loos, M. Modulation of mRNA expression and secretion of C1q in mouse macrophages by anti-inflammatory drugs and cAMP: evidence for the partial involvement of a pathway that includes cyclooxygenase, protaglandin E2 and adenylate cyclase. Immunol.84, 638–644 (1995). CAS Google Scholar
Andrews, B.S. & Theofilopoulos, A.N. A microassay for the determination of hemolytic complement activity in mouse serum. J. Immunol. Methods22, 273–281 (1978). ArticleCAS Google Scholar
Burlingame, R.W. & Rubin, R.L. Subnucleosome structures as substrates in enzyme-linked immunosorbent assays. J. Immunol. Methods134, 187–199 (1990). ArticleCAS Google Scholar