Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies (original) (raw)

References

  1. Walport, M.J. & Morgan, B.P. Complement deficiency and disease. Immunol. Today 12, 301–306 (1991).
    Article Google Scholar
  2. Lachmann, P.J. & Walport, M.J. Deficiency of the effector mechanisms of the immune response and autoimmunity. in Ciba Foundation Symposium: Autoimmunity and Autoimmune diseases (ed. Whelan, J.) 129, 149–171 (Wiley, Chichester, 1987).
    CAS Google Scholar
  3. McAdam, R.A., Goundis, D. & Reid, K.M.B. A homozygous point mutation results in a stop codon in the C1q B-chain of a Clq-deficient individual. Immunogenetics 27, 259–264 (1988).
    Article CAS Google Scholar
  4. Bowness, P. et al. Hereditary C1q deficiency and systemic lupus erythematosus. Quart. J. Med. 87, 455–464 (1994).
    CAS Google Scholar
  5. Petry, F., Le, D.T., Kirschfink, M. & Loos, M. Nonsense and missense mutations in the structural genes of complement component C1q A and C chains are linked with two different types of complete selective C1q deficiencies. J. Immunol. 155, 4734–4738 (1995).
    CAS PubMed Google Scholar
  6. Slingsby, J.H. et al. Homozygous hereditary C1q deficiency and systemic lupus erythematosus. A new family and the molecular basis of C1q deficiency in three families. Arthritis Rheum. 39, 663–670 (1996).
    Article CAS Google Scholar
  7. Topaloglu, R. et al. Molecular basis of hereditary C1q deficiency associated with SLE and IgA nephropathy in a Turkish family. Kidney Int. 50, 635–642 (1996).
    Article CAS Google Scholar
  8. Petry, F., Izzet Berkel, A. & Loos, M. Multiple identification of a particular type of hereditary C1q deficiency in the Turkish population: review of the cases andadditional genetic and functional analysis. Human Genet. 100, 51–56 (1997).
    Article CAS Google Scholar
  9. Petry, F. et al. The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organisation. Immunogenetics 43, 370–376 (1996).
    CAS PubMed Google Scholar
  10. Jevnikar, A.M., Slinger, G.G., Brennan, D.C., Xu, H.W. & Kelley, V.R. Dexamethasone prevents autoimmune nephritis and reduces renal expression of la but not costimulatory signals. Am. J. Pathol. 141, 743–751 (1992).
    CAS PubMed PubMed Central Google Scholar
  11. Baker, A.J. et al. Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. J. Clin. Invest. 94, 2105–2116 (1994).
    Article CAS Google Scholar
  12. Korb, L.C. & Ahearn, J.M. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes. Complement deficiency and systemic lupus erythematosus revisited. J. Immunol. 158, 4525–4528 (1997).
    CAS PubMed Google Scholar
  13. LeFeber, W.P. et al. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J. Clin. Invest. 74, 1545–1551 (1984).
    Article CAS Google Scholar
  14. Golan, T.D., Elkon, K.B., Gharavi, A.E. & Krueger, J.G. Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation. J. Clin. Invest. 90, 1067–1076 (1992).
    Article CAS Google Scholar
  15. Casciola-Rosen, L.A., Anhalt, G. & Rosen, A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 179, 1317–1330 (1994)
    Article CAS Google Scholar
  16. Rosen, A., Casciola-Rosen, L.A. & Ahearn, J. Novel packages of viral and self-antigens are generated during apoptosis. J. Exp. Med. 181, 1557–1561 (1995).
    Article CAS Google Scholar
  17. Casciola-Rosen, L.A., Rosen, A., Petri, M. & Schlissel, M. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: Implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA 93, 1624–1629 (1996).
    Article CAS Google Scholar
  18. Trinder, P., Faust, D., Petry, F. & Loos, M. Modulation of mRNA expression and secretion of C1q in mouse macrophages by anti-inflammatory drugs and cAMP: evidence for the partial involvement of a pathway that includes cyclooxygenase, protaglandin E2 and adenylate cyclase. Immunol. 84, 638–644 (1995).
    CAS Google Scholar
  19. Andrews, B.S. & Theofilopoulos, A.N. A microassay for the determination of hemolytic complement activity in mouse serum. J. Immunol. Methods 22, 273–281 (1978).
    Article CAS Google Scholar
  20. Burlingame, R.W. & Rubin, R.L. Subnucleosome structures as substrates in enzyme-linked immunosorbent assays. J. Immunol. Methods 134, 187–199 (1990).
    Article CAS Google Scholar

Download references