Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice (original) (raw)

References

  1. Birnbaumer, L. Receptor-to-effector signaling through G proteins: roles for βγ dimers as well as for α subunits. Cell 71, 1069–1072 (1992).
    Article CAS Google Scholar
  2. Montmayeur, J.-P. & Borrelli, E. Targeting of Gαi2 to the Golgi by alternative spliced carboxyl-terminal region. Science 263, 95–98 (1994).
    Article CAS Google Scholar
  3. Simonds, W.F., Goldsmith, P.K., Codina, J., Unson, C.G. & Spiegel, A.M. GB mediates α2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G C-terminal antibodies. Proc. natn. Acad. Sci. U.S.A. 86, 7809–7813 (1989).
    Article CAS Google Scholar
  4. Wong, Y.H. et al. Mutant α subunits of Gi2 inhibit cyclic AMP accumulation. Nature 351, 63–65 (1991).
    Article CAS Google Scholar
  5. Taussig, R., Iñiguez-Lluhi, J.A. & Gilman, A.G. Inhibition of adenylyl cyclase by Giα. Science 261, 218–221 (1993).
    Article CAS Google Scholar
  6. Yatani, A., Codina, J., Sekura, R.D., Birnbaumer, L. & Brown, A.M. Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated Gk protein in clonal rat anterior pituitary cell membranes. Molec. Endocrinol. 1, 283–289 (1987).
    Article CAS Google Scholar
  7. Yatani, A. et al. The G protein-gated atrial K+ channel is stimulated by three distinct G,α-subunits. Nature 336, 680–682 (1988).
    Article CAS Google Scholar
  8. Kirsch, G., Codina, J., Birnbaumer, L. & Brown, A.M. Coupling of ATP-sensitive K+ channels to purinergic receptors by G-Proteins in rat ventricular myocytes. Am. J. Physiol. 259, H820–H826 (1990).
    CAS PubMed Google Scholar
  9. Hermouet, S., Merendino, J.J., Gutkind, J.S. & Spiegel, A.M. Activating and inactivating mutations of the α subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells. Proc. natn. Acad. Sci. U.S.A. 88, 10455–10459 (1991).
    Article CAS Google Scholar
  10. Gupta, S.K., Gallego, C., Johnson, G. & Heasley, L.E. MAP kinase is constitutively activated in gip2 and src transformed Rat-1 a fibroblasts. J. biol. Chem. 267, 7987–7990 (1992).
    CAS Google Scholar
  11. Watkins, D.C., Johnson, G.L. & Malbon, C.C. Regulation of the differentiation of teratocarcinoma cells into primitive endoderm by Gαi2. Science 258, 1373–1375 (1992).
    Article CAS Google Scholar
  12. Moxham, C.M., Hod, Y. & Malbon, C.C. Induction of Gαi2-specific antisense RNA in vivo inhibits neonatal growth. Science 260, 991–995 (1993).
    Article CAS Google Scholar
  13. Pace, A.M., Wong, Y.H. & Bourne, H.R. A mutant α subunit of Gi2 induced neoplastic transformation of Rat-1 cells. Proc. natn. Acad. Sci. U.S.A. 88, 7031–7035 (1991).
    Article CAS Google Scholar
  14. Lyons, J. et al. Two G protein oncogenes in human endocrine tumours. Science 249, 655–659 (1990).
    Article CAS Google Scholar
  15. Noel, J.P., Hamm, H.E. & Sigler, P.B. The 2.2Å crystal structure of transducin-α complexed with GTPgS. Nature 366, 654–663 (1994).
    Article Google Scholar
  16. Rudolph, U., Brabet, P., Hasty, P., Bradley, A. & Birnbaumer, L. Disruption of the Gi2α locus in embryonic stem cells and mice: a modified hit and run strategy with detection by a PCR dependent on gap repair. Transgenic Res. 2, 345–355 (1993).
    Article CAS Google Scholar
  17. Fischer, M. et al. Cytokine production by mature and immature thymocytes. J. Immunol. 146, 3452–3456 (1991).
    CAS PubMed Google Scholar
  18. Elson, C.O., Ealding, W. & Lefkowitz, J. A lavage technique allowing repeated measurement of IgA antibody in mouse intestinal secretions. J. Immunol. Meth. 67, 101–108 (1984).
    Article CAS Google Scholar
  19. Schreiber, S., Raedler, A., Stenson, W.F. & MacDermott, R.P. The role of the mucosal immune system in inflammatory bowel disease. Gastroenterol. Clin. North Am. 21, 451–502 (1992).
    CAS PubMed Google Scholar
  20. Sadlack, B. et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75, 253–261 (1993).
    Article CAS Google Scholar
  21. Kühn, R., Löhler, J., Rennick, D., Rajewsky, K. & MüIIer, W. lnterleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263–274 (1993).
    Article Google Scholar
  22. Mombaerts, P. et al. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75, 275–282 (1993).
    Article CAS Google Scholar
  23. Morrissey, P.J., Charrier, K., Braddy, S., Liggitt, D. & Watson, J.D. CD4+T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficiency mice.Disease development is prevented by cotransfer of purified CD4+ T cells. J. exp. Med. 178, 237–244 (1993).
    Article CAS Google Scholar
  24. Powrie, F. et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhl CD4+ T cells. Immunity 1, 553–562 (1994).
    Article CAS Google Scholar
  25. Chaffin, K.E. et al. Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J. 9, 3821–3829 (1990).
    Article CAS Google Scholar
  26. Chaffin, K.E. & Perlmutter, R.M. A pertussis toxin-sensitive process controls thymocyte emigration. Eur. J. Immunol. 21, 2565–2573 (1991).
    Article CAS Google Scholar
  27. Bargatze, R.F. & Butcher, E.C. Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules. J. exp. Med. 178, 367–372 (1993).
    Article CAS Google Scholar
  28. Gupta, S.K. et al. Analysis of the fibroblast transformation potential of GTPase-deficient gip2 oncogenes. Mol. cell. Biol. 12, 190–197 (1992).
    Article CAS Google Scholar
  29. Hsu, W.H. et al. Molecular cloning of a novel splice variant of the α subunit of the mammalian G0 protein. J. biol. Chem. 265, 11220–11226 (1990).
    CAS PubMed Google Scholar
  30. Codina, J., Grenet, D., Chang, K.-J. & Birnbaumer, L., Gradient/SDS-PAGE: a useful tool in the investigation of signal transducing G proteins. J. Recept. Res. 11, 587–601 (1991).
    Article CAS Google Scholar
  31. Scherer, N.M., Toro, M.-J., Entman, M.L. & Birnbaumer, L. G protein distribution in canine cardiac sarcoplasmatic reticulum and sarcolemma.Comparison to rabbit sceletal membranes and brain and erythrocyte G proteins. Arch. Biochem. Biophys. 259, 431–440 (1987).
    Article CAS Google Scholar

Download references