Bcl-2 and Bax function independently to regulate cell death (original) (raw)
References
Bakhshi, A. et al. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell41, 899–906 (1985). ArticleCAS Google Scholar
Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E. & Croce, C.M. The t(14:18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science229, 1390–1393 (1985). ArticleCAS Google Scholar
Cleary, M.L. & Sklar, J. Nucleotide sequence of a t(14:18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc. Atal. Acad. Sci. USA.82, 7439–7443 (1995). Article Google Scholar
Vaux, D.L., Cory, S. & Adams, J.M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature335, 440–442 (1988). ArticleCAS Google Scholar
McDonnell, T.J. et al. Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell57, 79–88 (1989). ArticleCAS Google Scholar
Yang, E. & Korsmeyer, S.J. Molecular thanatopsis: a discourse on the Bcl2 family and cell death. Blood88, 386–401 (1996). CAS Google Scholar
Farrow, S.N. & Brown, R. New members of the BCL-2 family and their protein partners. Curr. Opin. Gen. Dev.6, 45–49 (1996). ArticleCAS Google Scholar
Nakayama, K., Negishi, I., Kuida, K., Sawa, H. & Loh, D.Y. Targeted disruption of Bcl-2 ab in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc. Atal. Acad. Sci. USA91, 3700–3704 (1994). ArticleCAS Google Scholar
Kamada, S. et al. Bcl-2 deficiency in mice leads to pleitrophic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res.55, 354–359 (1995). CASPubMed Google Scholar
Motoyama, N. et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x–deficient mice. Science267, 1506–1510 (1995). ArticleCAS Google Scholar
Ma, A. et al. Bclx regulates the survival of double-positive thymocytes. Proc. Atal. Acad. Sci. USA92, 4763–4767 (1995). ArticleCAS Google Scholar
Knudson, C.M., Tung, K.S., Tourtellotte, W.G., Brown, G.A. & Korsmeyer, S.J. Bax-deficient mice with lymphoid hyperplasia and male gerrn cell death. Science270, 96–99 (1995). ArticleCAS Google Scholar
Deckwerth, T.L. et al. Bax is required for neuronal death after trophic factor deprivation and during development. Neuron17, 401–411 (1996). ArticleCAS Google Scholar
Sedlak, T.W. et al. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc. Atal. Acad. Sci. USA92, 7834–7838 (1995). ArticleCAS Google Scholar
Sato, S. et al. Interactions among members of the BCL-2 protein family analyzed with a yeast two-hybrid system. Proc. Atal. Acad. Sci. USA91, 9238–9242 (1994). ArticleCAS Google Scholar
Yin, X.-M., Oltvai, Z.N. & Korsmeyer, S.J. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature369, 321–323 (1994). ArticleCAS Google Scholar
Cheng, E.H.-Y., Levine, B., Boise, L.H., Thompson, C.B. & Hardwick, J.M. Bax-independent inhibition of apoptosis by Bcl-xL. Nature379, 554–556 (1996). ArticleCAS Google Scholar
Chittenden, T. et al. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J.14, 5589–5596 (1995). ArticleCAS Google Scholar
Veis, D.J., Sentman, C.L., Bach, E.A. & Korsmeyer, S.J. Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol.151, 2546–2554 (1993). CASPubMed Google Scholar
Veis-Novack, D.J. & Korsmeyer, S.J. Bcl-2 protein expression during murine development. Am. J. Pathol.145, 61–73 (1994). Google Scholar
Sentman, C.L., Shutter, J.R., Hockenbery, D., Kanagawa, O. & Korsmeyer, S.J. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell.67, 879–888 (1991). ArticleCAS Google Scholar
Linette, G.P., Li, Y, Roth, K.A, rsmeyer, S.J. Crosstalk between cell death and cell cycle progression: Bcl-2 regulates NFAT-mediated activation. Proc. Atal. Acad. Sci. USA93, 9545–9552 (1996). ArticleCAS Google Scholar
Uhlmann, E.J. et al. Deletion of a nonconserved region of Bcl-2 confers a novel gain of function-suppression of apoptosis with a concomitant cell proliferation. Cancer Res.56, 2506–2509 (1996). CASPubMed Google Scholar
Raff, M.C. Social controls on cell survival and cell death [review]. Nature356, 397–400 (1992). ArticleCAS Google Scholar
Shaham, S. & Horvitz, H.R. Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. Genes Dev.10, 578–591 (1996). ArticleCAS Google Scholar
Martin, S.J. & Green, D.R. Protease activation during apoptosis: death by a thousand cuts. cell82, 349–352 (1995). ArticleCAS Google Scholar
Boulakia, C.A. et al. Bcl-2 and adenovirus E1B 19 kda protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase. Oncogene12, 529–535 (1996). CASPubMed Google Scholar
Armstrong, R.C. et al. Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors. J .Biol. Chem.271, 16850–16855 (1996). ArticleCAS Google Scholar
Chinnaiyan, A.M. et al. Molecular ordering of the cell death pathway—Bcl-2 and Bcl-xL function upstream of the ced-3-like apoptotic proteases. j. Biol. Chem.271, 4573–4576 (1996). ArticleCAS Google Scholar
Shimizu, S., Eguchi, Y., Kamiike, W., Matsuda, H. & Tsujimoto, Y. Bcl-2 expression prevents activation of the ice protease cascade. Oncogene12, 2251–2257 (1996). CASPubMed Google Scholar
Shaham, S. & Horvitz, H.R. An alternatively spliced C . elegans ced-4 RNA encodes a novel cell death inhibitor. cell86, 201–208 (1996). ArticleCAS Google Scholar
Shaham, S. & Horvitz, H.R. Developing caenorhabditis elegans neurons may contain both cell-death protective and killer activities [review]. Genes Dev.10, 578–591 (1996). ArticleCAS Google Scholar
Muchmore, S.W. et al. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature381, 335–341 (1996). ArticleCAS Google Scholar
Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R.D. & Korsmeyer, S.J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature348, 334–336 (1990). ArticleCAS Google Scholar
Chao, D.T. et al. Bcl-XL and Bcl-2 repress a common pathway of cell death. J. Exp. Med.182, 821–828 (1995). ArticleCAS Google Scholar
Oltvai, Z.N., Milliman, C.L. & Korsmeyer, S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell74, 609–619 (1993). ArticleCAS Google Scholar
Linette, G.P. et al. Bcl-2 is upregulated at the CD4+CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity1, 197–205 (1994). ArticleCAS Google Scholar
Xiang, J., Chao, D.T. & Korsmeyer, S.J. Bax-induced cell death may not require interleukin 1 b-converting enzyme-like proteases. Proc. Atal. Acad. Sci. USA93, 14559–14563 (1996). ArticleCAS Google Scholar
Wang, K., Yin, X.M., Chao, D.T., Milliman, C.L. & Korsmeyer, S.J. BID: a novel BH3 domain-only death agonist. Genes Dev.10, 2859–2869 (1996). ArticleCAS Google Scholar
Yang, E. et al. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. cell.80, 285–291 (1995). ArticleCAS Google Scholar