A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 (original) (raw)
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References
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Acknowledgements
We thank the patients and other members of the ALS2 families for participating in this study; A.E. MacKenzie, R.G. Korneluk, I. Kanazawa, J.-C. Barbot and J.-C. Kaplan for providing control DNA samples; D. Rochefort for technical support; and all the members of our laboratories for helpful discussion and suggestions. This work was funded by the Japan Science and Technology Corporation, the Canadian Genetic Diseases Network, the Centre for Molecular Medicine and Therapeutics, the Nakabayashi Trust For ALS Research, the Japan Brain Foundation, the Grant-in-Aid for Scientific Research Priority Areas for the Ministry of Education, Science, Sports, and Culture (Japan), the Canadian Institute for Health Research, the Muscular Dystrophy Association (USA), the Amyotrophic Lateral Sclerosis Association, the National Institute for Neurological Disease (USA), National Institute for Aging (USA), Angel Fund for ALS Research (Boston, USA), Project ALS (New York, USA), Pierre L. DeBourgknecht ALS Research Foundation and Al-Athel ALS Foundation. M.R.H. is a holder of a Canada Research Chair. G.A.R. is supported by the Canadian Institute of Health Research. S.W.S. is a Scholar of the Medical Research Council of Canada. J.-E.I. is a scientific director of NeuroGenes/International Cooperative Research Project/Japan Science and Technology Corporation.
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Authors and Affiliations
- NeuroGenes, International Cooperative Research Project, Japan Science and Technology Corporation, Tokai University School of Medicine, Isehara, 259-1193, Kanagawa, Japan
Shinji Hadano, Hitoshi Osuga, Yoshiko Yanagisawa, Asako Otomo, Natsuki Miyamoto & Joh-E Ikeda - Department of Molecular Neuroscience, The Institute of Medical Sciences, Tokai University, Isehara, Kanagawa, Japan
Shinji Hadano, Hitoshi Osuga, Junko Showguchi-Miyata, Yoshinori Okada & Joh-E Ikeda - Centre for Research in Neuroscience, McGill University, and Montreal General Hospital Research Institute, Montreal, Quebec, Canada
Collette K. Hand & Guy A. Rouleau - Department of Medical Genetics, and Centre for Molecular Medicine and Therapeutics, University of British Columbia and Children's and Women's Hospital, Vancouver, British Columbia, Canada
Rebecca S. Devon, Roshni Singaraja, Jamal Nasir & Michael R. Hayden - Departments of Neurology and Neurobiology & Anatomy, University of Rochester Medical Center, Rochester, New York, USA
Denise A. Figlewicz - Day Neuromuscular Research Laboratory, Navy Yard, Charlestown, Massachusetts, USA
Thomas Kwiatkowski, Betsy A. Hosler & Robert H. Brown Jr - Pediatric Neurology and Metabolic Neurogenetic Clinic, E. Wolfson Medical Center, Holon, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Tally Sagie - Department of Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada
Jennifer Skaug & Stephen W. Scherer - Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
Jamal Nasir - Department of Paediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Joh-E Ikeda
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- Shinji Hadano
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Corresponding authors
Correspondence toMichael R. Hayden or Joh-E Ikeda.
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Hadano, S., Hand, C., Osuga, H. et al. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.Nat Genet 29, 166–173 (2001). https://doi.org/10.1038/ng1001-166
- Received: 05 June 2001
- Accepted: 09 July 2001
- Issue Date: 01 October 2001
- DOI: https://doi.org/10.1038/ng1001-166