Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas (original) (raw)

Nature Genetics volume 32, pages 355–357 (2002)Cite this article

A Corrigendum to this article was published on 01 December 2002

Abstract

We have recently shown that loss of heterozygosity of specific markers, including those at 10q23, 17p13–p15 and 16q24, can occur in the stromal and epithelial compartments of primary invasive breast carcinomas. Here, we demonstrate high frequencies of somatic mutations in TP53 (encoding tumor protein p53) and PTEN (encoding phosphate and tensin homolog) in breast neoplastic epithelium and stroma. Mutations in TP53 and PTEN are mutually exclusive in either compartment. In contrast, mutations in WFDC1 (16q24, encoding WAP four-disulfide core domain 1) occur with low frequency in the stroma.

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Figure 1: Somatic mutations in TP53 or PTEN in epithelium or stroma of breast carcinoma samples.

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References

  1. Tomlinson, I.P.M.T., Lambros, M.B.K., Roylance, R.R. & Cleton-Jansen, A.-M. Genes Chromosom. Cancer 34, 349–353 (2002).
    Article Google Scholar
  2. Kurose, K. et al. Hum. Mol. Genet. 10, 1907–1913 (2001).
    Article CAS Google Scholar
  3. Eng, C. & Parsons, R. in The Metabolic and Molecular Bases of Inherited Disease vol. 1 (eds Scriver, C., Beaudet, A.L., Sly, W.S. and Valle, D.) 979–988 (McGraw–Hill Medical Publishing, New York, 2001).
    Google Scholar
  4. Larsen, M. et al. Mammal. Genome 11, 767–773 (2000).
    Article CAS Google Scholar
  5. Mutter, G.L. et al. J. Natl Cancer Inst. 92, 924–931 (2000).
    Article CAS Google Scholar
  6. Wernert, N., Löcherbach, C., Wellmann, A., Behrens, P. & Hügel, A. Anticancer Res. 21, 2259–2264 (2001).
    CAS PubMed Google Scholar
  7. Stambolic, V. et al. Mol. Cell 8, 317–325 (2001).
    Article CAS Google Scholar
  8. Perren, A. et al. Am. J. Pathol. 155, 1253–1260 (1999).
    Article CAS Google Scholar

Download references

Acknowledgements

We are grateful to M. Ostrowski and G. Leone for helpful discussions and to C. Morrison, M. Prasad and A. Adewale for assistance. This work was supported in part by the Jimmy V Golf Classic Award for Translational Cancer Research from the V Foundation (to C.E.), the American Cancer Society (to C.E.), the Department of Defense US Army Breast Cancer Research Program (to P.H.W. and C.E.) and the National Cancer Institute (to The Ohio State University Comprehensive Cancer Center).

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Author notes

  1. Keisuke Kurose, Kristie Gilley and Satoshi Matsumoto: These authors contributed equally to this work.

Authors and Affiliations

  1. Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Center,
    Keisuke Kurose, Kristie Gilley, Satoshi Matsumoto, Xiao-Ping Zhou & Charis Eng
  2. the Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, 43210, Ohio, USA
    Keisuke Kurose, Kristie Gilley, Satoshi Matsumoto, Xiao-Ping Zhou & Charis Eng
  3. Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada
    Peter H. Watson
  4. Cancer Research, UK Human Cancer Genetics Research Group, University of Cambridge, Cambridge, CB2 2XZ, UK
    Charis Eng

Authors

  1. Keisuke Kurose
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  2. Kristie Gilley
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  3. Satoshi Matsumoto
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  4. Peter H. Watson
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  5. Xiao-Ping Zhou
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  6. Charis Eng
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Correspondence toCharis Eng.

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The authors declare no competing financial interests.

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Kurose, K., Gilley, K., Matsumoto, S. et al. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas.Nat Genet 32, 355–357 (2002). https://doi.org/10.1038/ng1013

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