Transferability of tag SNPs in genetic association studies in multiple populations (original) (raw)

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Acknowledgements

We thank M. Egyud for sharing unpublished results and all members of the collaborative Multiethnic Cohort Study and the Analysis group of the International HapMap Consortium for useful discussions. We acknowledge the support of NIH grants CA63464 and CA098758 (to B.E.H.), HL074166 (to X.Z.), CA54281 (to L.N.K.) and DK067288 (to H.N.L.); a March of Dimes grant (6-FY04-61, to J.N.H.) and a Charles E. Culpeper Scholarship of the Rockefeller Brothers Fund and a Burroughs Wellcome Fund Clinical Scholarship in Translational Research (both to D.A.).

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Author notes

1. Paul I W de Bakker, Noël P Burtt and Robert R Graham: These authors contributed equally to this work.

Authors and Affiliations

1. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, 02142, Massachusetts, USA
   Paul I W de Bakker, Noël P Burtt, Robert R Graham, Candace Guiducci, Roman Yelensky, Jared A Drake, Todd Bersaglieri, Johannah Butler, Robert C Onofrio, Helen N Lyon, Matthew L Freedman, Mark J Daly, Joel N Hirschhorn & David Altshuler
2. Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, 02114-2790, Massachusetts, USA
   Paul I W de Bakker, Robert R Graham, Roman Yelensky, Stanton Young, Mark J Daly & David Altshuler
3. Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, 02114-2790, Massachusetts, USA
   Paul I W de Bakker, Robert R Graham, Roman Yelensky, Stanton Young & David Altshuler
4. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
   Paul I W de Bakker, Robert R Graham, Joel N Hirschhorn & David Altshuler
5. Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
   Roman Yelensky
6. Divisions of Endocrinology and Genetics, Program in Genomics, Children's Hospital, Boston, 02115, Massachusetts, USA
   Jared A Drake, Todd Bersaglieri, Johannah Butler, Helen N Lyon & Joel N Hirschhorn
7. Harvard School of Public Health, Boston, 02115, Massachusetts, USA
   Kathryn L Penney
8. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90089, California, USA
   Daniel O Stram, Christopher A Haiman & Brian E Henderson
9. Dana-Farber Cancer Institute, Boston, 02115, Massachusetts, USA
   Matthew L Freedman
10. Department of Preventive Medicine and Epidemiology, Loyola University, Maywood, 60153, Illinois, USA
    Xiaofeng Zhu & Richard Cooper
11. Department of Clinical Sciences, University Hospital, Lund University, Malmö, S-20502, Sweden
    Leif Groop
12. Department of Medicine, Helsinki University, Helsinki, Finland
    Leif Groop
13. Cancer Research Center, University of Hawaii, Honolulu, 96813, Hawaii, USA
    Laurence N Kolonel
14. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Mark J Daly & David Altshuler
15. Diabetes Unit, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA
    David Altshuler

Authors

1. Paul I W de Bakker
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2. Noël P Burtt
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3. Robert R Graham
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4. Candace Guiducci
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5. Roman Yelensky
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6. Jared A Drake
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7. Todd Bersaglieri
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8. Kathryn L Penney
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9. Johannah Butler
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10. Stanton Young
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11. Robert C Onofrio
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12. Helen N Lyon
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13. Daniel O Stram
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14. Christopher A Haiman
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15. Matthew L Freedman
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16. Xiaofeng Zhu
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17. Richard Cooper
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18. Leif Groop
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19. Laurence N Kolonel
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20. Brian E Henderson
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21. Mark J Daly
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22. Joel N Hirschhorn
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23. David Altshuler
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Contributions

H.N.L., X.Z., R.C., L.G., C.A.H., L.N.K., B.E.H. provided DNA samples; N.P.B. coordinated resequencing with R.C.O. and S.Y.; N.P.B., R.R.G., C.G., J.B., K.L.P. prepared DNA samples, designed and performed genotyping experiments; P.d.B., N.P.B., R.R.G., R.Y., J.A.D. and T.B. performed the analyses; P.d.B. wrote the paper, with contributions from N.P.B. and R.R.G.; M.L.F., C.A.H., D.O.S. and H.N.L. gave feedback and helped with revisions and M.J.D., J.N.H. and D.A. jointly directed the project.

Corresponding author

Correspondence toDavid Altshuler.

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The authors declare no competing financial interests.

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de Bakker, P., Burtt, N., Graham, R. et al. Transferability of tag SNPs in genetic association studies in multiple populations.Nat Genet 38, 1298–1303 (2006). https://doi.org/10.1038/ng1899

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• Received: 23 March 2006
• Accepted: 12 September 2006
• Published: 22 October 2006
• Issue Date: 01 November 2006
• DOI: https://doi.org/10.1038/ng1899